Microwave assisted facile one pot synthesis of novel 5-carboxamido substituted analogues of 1,4-benzodiazepin-2-one of medicinal interest
A novel synthetic approach developed by the use of a microwave (MW) assisted one pot protocol to the synthesis of methyl-1,4-benzodiazepin-2-one-5-carboxylate (<b>2</b>) derivatives for which <i>N</i>-chloroacetylisatin was employed with an elegant success to afford the forma...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Chemical Society of Ethiopia
2013-05-01
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| Series: | Bulletin of the Chemical Society of Ethiopia |
| Subjects: | |
| Online Access: | http://www.ajol.info/index.php/bcse/article/view/88836 |
| Summary: | A novel synthetic approach developed by the use of a microwave (MW) assisted one pot protocol to the synthesis of methyl-1,4-benzodiazepin-2-one-5-carboxylate (<b>2</b>) derivatives for which <i>N</i>-chloroacetylisatin was employed with an elegant success to afford the formation of 5-methyl carboxylate derivatives of 1,4-benzodiazepines from its reaction with methanolic hexamine. We have utilized MW technique in the present work in conducting the reaction of carboxylate ester derivative (<b>2</b>) with several selected primary and secondary amines <b>3</b>, <b>4</b>, <b>5</b>, <b>6</b>, <b>7</b>, and <b>8</b> which had the previous history of being biologically active in the literature, to generate the corresponding carboxamide derivatives (<b>9-14</b>). |
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| ISSN: | 1011-3924 1726-801X |