Microwave assisted facile one pot synthesis of novel 5-carboxamido substituted analogues of 1,4-benzodiazepin-2-one of medicinal interest
A novel synthetic approach developed by the use of a microwave (MW) assisted one pot protocol to the synthesis of methyl-1,4-benzodiazepin-2-one-5-carboxylate (<b>2</b>) derivatives for which <i>N</i>-chloroacetylisatin was employed with an elegant success to afford the forma...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Chemical Society of Ethiopia
2013-05-01
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| Series: | Bulletin of the Chemical Society of Ethiopia |
| Subjects: | |
| Online Access: | http://www.ajol.info/index.php/bcse/article/view/88836 |
| _version_ | 1819081322688151552 |
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| author | R. Sirohi P. Sharma N. Kaur P. Sharma D. Kishore |
| author_facet | R. Sirohi P. Sharma N. Kaur P. Sharma D. Kishore |
| author_sort | R. Sirohi |
| collection | DOAJ |
| description | A novel synthetic approach developed by the use of a microwave (MW) assisted one pot protocol to the synthesis of methyl-1,4-benzodiazepin-2-one-5-carboxylate (<b>2</b>) derivatives for which <i>N</i>-chloroacetylisatin was employed with an elegant success to afford the formation of 5-methyl carboxylate derivatives of 1,4-benzodiazepines from its reaction with methanolic hexamine. We have utilized MW technique in the present work in conducting the reaction of carboxylate ester derivative (<b>2</b>) with several selected primary and secondary amines <b>3</b>, <b>4</b>, <b>5</b>, <b>6</b>, <b>7</b>, and <b>8</b> which had the previous history of being biologically active in the literature, to generate the corresponding carboxamide derivatives (<b>9-14</b>). |
| first_indexed | 2024-12-21T19:58:56Z |
| format | Article |
| id | doaj.art-49b71c123bc34a4194d09ee119c34b81 |
| institution | Directory Open Access Journal |
| issn | 1011-3924 1726-801X |
| language | English |
| last_indexed | 2024-12-21T19:58:56Z |
| publishDate | 2013-05-01 |
| publisher | Chemical Society of Ethiopia |
| record_format | Article |
| series | Bulletin of the Chemical Society of Ethiopia |
| spelling | doaj.art-49b71c123bc34a4194d09ee119c34b812022-12-21T18:52:01ZengChemical Society of EthiopiaBulletin of the Chemical Society of Ethiopia1011-39241726-801X2013-05-01272301307http://dx.doi.org/10.4314/bcse.v27i2.16Microwave assisted facile one pot synthesis of novel 5-carboxamido substituted analogues of 1,4-benzodiazepin-2-one of medicinal interestR. SirohiP. SharmaN. KaurP. SharmaD. KishoreA novel synthetic approach developed by the use of a microwave (MW) assisted one pot protocol to the synthesis of methyl-1,4-benzodiazepin-2-one-5-carboxylate (<b>2</b>) derivatives for which <i>N</i>-chloroacetylisatin was employed with an elegant success to afford the formation of 5-methyl carboxylate derivatives of 1,4-benzodiazepines from its reaction with methanolic hexamine. We have utilized MW technique in the present work in conducting the reaction of carboxylate ester derivative (<b>2</b>) with several selected primary and secondary amines <b>3</b>, <b>4</b>, <b>5</b>, <b>6</b>, <b>7</b>, and <b>8</b> which had the previous history of being biologically active in the literature, to generate the corresponding carboxamide derivatives (<b>9-14</b>).http://www.ajol.info/index.php/bcse/article/view/88836MorpholinePiperidinePiperazinePyridinePyrimidine |
| spellingShingle | R. Sirohi P. Sharma N. Kaur P. Sharma D. Kishore Microwave assisted facile one pot synthesis of novel 5-carboxamido substituted analogues of 1,4-benzodiazepin-2-one of medicinal interest Bulletin of the Chemical Society of Ethiopia Morpholine Piperidine Piperazine Pyridine Pyrimidine |
| title | Microwave assisted facile one pot synthesis of novel 5-carboxamido substituted analogues of 1,4-benzodiazepin-2-one of medicinal interest |
| title_full | Microwave assisted facile one pot synthesis of novel 5-carboxamido substituted analogues of 1,4-benzodiazepin-2-one of medicinal interest |
| title_fullStr | Microwave assisted facile one pot synthesis of novel 5-carboxamido substituted analogues of 1,4-benzodiazepin-2-one of medicinal interest |
| title_full_unstemmed | Microwave assisted facile one pot synthesis of novel 5-carboxamido substituted analogues of 1,4-benzodiazepin-2-one of medicinal interest |
| title_short | Microwave assisted facile one pot synthesis of novel 5-carboxamido substituted analogues of 1,4-benzodiazepin-2-one of medicinal interest |
| title_sort | microwave assisted facile one pot synthesis of novel 5 carboxamido substituted analogues of 1 4 benzodiazepin 2 one of medicinal interest |
| topic | Morpholine Piperidine Piperazine Pyridine Pyrimidine |
| url | http://www.ajol.info/index.php/bcse/article/view/88836 |
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