The Controversial Role of Human Gut Lachnospiraceae
The complex polymicrobial composition of human gut microbiota plays a key role in health and disease. Lachnospiraceae belong to the core of gut microbiota, colonizing the intestinal lumen from birth and increasing, in terms of species richness and their relative abundances during the host’s life. Al...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/8/4/573 |
| _version_ | 1827718612831436800 |
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| author | Mirco Vacca Giuseppe Celano Francesco Maria Calabrese Piero Portincasa Marco Gobbetti Maria De Angelis |
| author_facet | Mirco Vacca Giuseppe Celano Francesco Maria Calabrese Piero Portincasa Marco Gobbetti Maria De Angelis |
| author_sort | Mirco Vacca |
| collection | DOAJ |
| description | The complex polymicrobial composition of human gut microbiota plays a key role in health and disease. Lachnospiraceae belong to the core of gut microbiota, colonizing the intestinal lumen from birth and increasing, in terms of species richness and their relative abundances during the host’s life. Although, members of Lachnospiraceae are among the main producers of short-chain fatty acids, different taxa of Lachnospiraceae are also associated with different intra- and extraintestinal diseases. Their impact on the host physiology is often inconsistent across different studies. Here, we discuss changes in Lachnospiraceae abundances according to health and disease. With the aim of harnessing Lachnospiraceae to promote human health, we also analyze how nutrients from the host diet can influence their growth and how their metabolites can, in turn, influence host physiology. |
| first_indexed | 2024-03-10T20:26:59Z |
| format | Article |
| id | doaj.art-49b830d129e746df9de499a1280c42f1 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T20:26:59Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-49b830d129e746df9de499a1280c42f12023-11-19T21:43:56ZengMDPI AGMicroorganisms2076-26072020-04-018457310.3390/microorganisms8040573The Controversial Role of Human Gut LachnospiraceaeMirco Vacca0Giuseppe Celano1Francesco Maria Calabrese2Piero Portincasa3Marco Gobbetti4Maria De Angelis5Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, 70126 Bari, ItalyDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, 70126 Bari, ItalyDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, 70126 Bari, ItalyClinica Medica “A. Murri”, Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, 70121 Bari, ItalyFaculty of Science and Technology, Free University of Bozen, 39100 Bolzano, ItalyDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, 70126 Bari, ItalyThe complex polymicrobial composition of human gut microbiota plays a key role in health and disease. Lachnospiraceae belong to the core of gut microbiota, colonizing the intestinal lumen from birth and increasing, in terms of species richness and their relative abundances during the host’s life. Although, members of Lachnospiraceae are among the main producers of short-chain fatty acids, different taxa of Lachnospiraceae are also associated with different intra- and extraintestinal diseases. Their impact on the host physiology is often inconsistent across different studies. Here, we discuss changes in Lachnospiraceae abundances according to health and disease. With the aim of harnessing Lachnospiraceae to promote human health, we also analyze how nutrients from the host diet can influence their growth and how their metabolites can, in turn, influence host physiology.https://www.mdpi.com/2076-2607/8/4/573Lachnospiraceaegut microbiotagut microbial pathwaysgut microbial metaboliteshealthdisease |
| spellingShingle | Mirco Vacca Giuseppe Celano Francesco Maria Calabrese Piero Portincasa Marco Gobbetti Maria De Angelis The Controversial Role of Human Gut Lachnospiraceae Microorganisms Lachnospiraceae gut microbiota gut microbial pathways gut microbial metabolites health disease |
| title | The Controversial Role of Human Gut Lachnospiraceae |
| title_full | The Controversial Role of Human Gut Lachnospiraceae |
| title_fullStr | The Controversial Role of Human Gut Lachnospiraceae |
| title_full_unstemmed | The Controversial Role of Human Gut Lachnospiraceae |
| title_short | The Controversial Role of Human Gut Lachnospiraceae |
| title_sort | controversial role of human gut lachnospiraceae |
| topic | Lachnospiraceae gut microbiota gut microbial pathways gut microbial metabolites health disease |
| url | https://www.mdpi.com/2076-2607/8/4/573 |
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