Effect of social disparities on 10 year survival in pediatric patients with Wilms' tumor
Abstract Background To stratify 10‐year survival outcomes by degree of social disparities in pediatric Wilms' tumor patients. We applied the Social Deprivation Index (SDI) to survival outcomes from the national SEER database to elucidate the effects of lower socioeconomics on cancer survival. M...
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| Format: | Article |
| Language: | English |
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Wiley
2023-02-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.5124 |
| _version_ | 1797903089458479104 |
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| author | Victor Chalfant Carlos Riveros Andrew A. Stec |
| author_facet | Victor Chalfant Carlos Riveros Andrew A. Stec |
| author_sort | Victor Chalfant |
| collection | DOAJ |
| description | Abstract Background To stratify 10‐year survival outcomes by degree of social disparities in pediatric Wilms' tumor patients. We applied the Social Deprivation Index (SDI) to survival outcomes from the national SEER database to elucidate the effects of lower socioeconomics on cancer survival. Methods A retrospective cohort study was performed using the national Surveillance, Epidemiology, and End Results (SEER) oncology registry from 1975 to 2016 based on county‐level data. Pediatric patients (<18 years old) with a diagnosis of WT (C64.9) and confirmed based on histology codes (8960/8963) were included. SDI scores were calculated for each patient and initially divided into quintiles. Patients were delineated into high‐risk (>60th percentile/more deprived) or low‐risk (<60th percentile/less deprived) groups. Statistics were assessed using Fisher's exact test, Student's t‐test, and Kaplan–Meier assessed survival differences with log‐rank test for trend. Results A total of 3406 patients were included with 1366 patients reported in the high‐risk group and 2040 patients in the low‐risk group. Quintile data demonstrated a stratification in survival based on socioeconomic status. Patients in more socially deprived counties were significantly (p = 0.035) more likely to have worse overall survival compared with those living in less deprived areas at 10‐year (87.3% vs 89.3%) follow‐up. Conclusions 10‐year overall and cancer‐specific survival data for patients with Wilms' tumor stratify by socioeconomic lines. This represents an area that needs to be addressed in this pediatric oncologic population. Patients from more socially deprived areas have significantly worse 10‐year overall survival rates and noticeably different 10‐year cancer‐specific survival rates. |
| first_indexed | 2024-04-10T09:27:29Z |
| format | Article |
| id | doaj.art-49bd509ef8ac455d9a798ed2f0cc6202 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-10T09:27:29Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-49bd509ef8ac455d9a798ed2f0cc62022023-02-19T18:54:08ZengWileyCancer Medicine2045-76342023-02-011233452345910.1002/cam4.5124Effect of social disparities on 10 year survival in pediatric patients with Wilms' tumorVictor Chalfant0Carlos Riveros1Andrew A. Stec2Department of Urology Creighton University School of Medicine Omaha Nebraska USADepartment of Urology University of Florida Health Jacksonville Florida USADivision of Urology Nemours Children's Health Jacksonville Florida USAAbstract Background To stratify 10‐year survival outcomes by degree of social disparities in pediatric Wilms' tumor patients. We applied the Social Deprivation Index (SDI) to survival outcomes from the national SEER database to elucidate the effects of lower socioeconomics on cancer survival. Methods A retrospective cohort study was performed using the national Surveillance, Epidemiology, and End Results (SEER) oncology registry from 1975 to 2016 based on county‐level data. Pediatric patients (<18 years old) with a diagnosis of WT (C64.9) and confirmed based on histology codes (8960/8963) were included. SDI scores were calculated for each patient and initially divided into quintiles. Patients were delineated into high‐risk (>60th percentile/more deprived) or low‐risk (<60th percentile/less deprived) groups. Statistics were assessed using Fisher's exact test, Student's t‐test, and Kaplan–Meier assessed survival differences with log‐rank test for trend. Results A total of 3406 patients were included with 1366 patients reported in the high‐risk group and 2040 patients in the low‐risk group. Quintile data demonstrated a stratification in survival based on socioeconomic status. Patients in more socially deprived counties were significantly (p = 0.035) more likely to have worse overall survival compared with those living in less deprived areas at 10‐year (87.3% vs 89.3%) follow‐up. Conclusions 10‐year overall and cancer‐specific survival data for patients with Wilms' tumor stratify by socioeconomic lines. This represents an area that needs to be addressed in this pediatric oncologic population. Patients from more socially deprived areas have significantly worse 10‐year overall survival rates and noticeably different 10‐year cancer‐specific survival rates.https://doi.org/10.1002/cam4.5124social deprivation indexsocial determinants of healthsocioeconomic statussurvival outcomesWilms' tumor |
| spellingShingle | Victor Chalfant Carlos Riveros Andrew A. Stec Effect of social disparities on 10 year survival in pediatric patients with Wilms' tumor Cancer Medicine social deprivation index social determinants of health socioeconomic status survival outcomes Wilms' tumor |
| title | Effect of social disparities on 10 year survival in pediatric patients with Wilms' tumor |
| title_full | Effect of social disparities on 10 year survival in pediatric patients with Wilms' tumor |
| title_fullStr | Effect of social disparities on 10 year survival in pediatric patients with Wilms' tumor |
| title_full_unstemmed | Effect of social disparities on 10 year survival in pediatric patients with Wilms' tumor |
| title_short | Effect of social disparities on 10 year survival in pediatric patients with Wilms' tumor |
| title_sort | effect of social disparities on 10 year survival in pediatric patients with wilms tumor |
| topic | social deprivation index social determinants of health socioeconomic status survival outcomes Wilms' tumor |
| url | https://doi.org/10.1002/cam4.5124 |
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