Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers
Viral infections are a major global health problem, representing a significant cause of mortality with an unfavorable continuously amplified socio-economic impact. The increased drug resistance and constant viral replication have been the trigger for important studies regarding the use of nanotechno...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/12/2/171 |
| _version_ | 1811303927431299072 |
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| author | Florina-Daniela Cojocaru Doru Botezat Ioannis Gardikiotis Cristina-Mariana Uritu Gianina Dodi Laura Trandafir Ciprian Rezus Elena Rezus Bogdan-Ionel Tamba Cosmin-Teodor Mihai |
| author_facet | Florina-Daniela Cojocaru Doru Botezat Ioannis Gardikiotis Cristina-Mariana Uritu Gianina Dodi Laura Trandafir Ciprian Rezus Elena Rezus Bogdan-Ionel Tamba Cosmin-Teodor Mihai |
| author_sort | Florina-Daniela Cojocaru |
| collection | DOAJ |
| description | Viral infections are a major global health problem, representing a significant cause of mortality with an unfavorable continuously amplified socio-economic impact. The increased drug resistance and constant viral replication have been the trigger for important studies regarding the use of nanotechnology in antiviral therapies. Nanomaterials offer unique physico-chemical properties that have linked benefits for drug delivery as ideal tools for viral treatment. Currently, different types of nanomaterials namely nanoparticles, liposomes, nanospheres, nanogels, nanosuspensions and nanoemulsions were studied either in vitro or in vivo for drug delivery of antiviral agents with prospects to be translated in clinical practice. This review highlights the drug delivery nanosystems incorporating the major antiviral classes and their transport across specific barriers at cellular and intracellular level. Important reflections on nanomedicines currently approved or undergoing investigations for the treatment of viral infections are also discussed. Finally, the authors present an overview on the requirements for the design of antiviral nanotherapeutics. |
| first_indexed | 2024-04-13T07:56:42Z |
| format | Article |
| id | doaj.art-49bf1791dee94d8a869b2c9ea6bc5c7f |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-13T07:56:42Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-49bf1791dee94d8a869b2c9ea6bc5c7f2022-12-22T02:55:22ZengMDPI AGPharmaceutics1999-49232020-02-0112217110.3390/pharmaceutics12020171pharmaceutics12020171Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological BarriersFlorina-Daniela Cojocaru0Doru Botezat1Ioannis Gardikiotis2Cristina-Mariana Uritu3Gianina Dodi4Laura Trandafir5Ciprian Rezus6Elena Rezus7Bogdan-Ionel Tamba8Cosmin-Teodor Mihai9Advanced Centre for Research-Development in Experimental Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, RomaniaAdvanced Centre for Research-Development in Experimental Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, RomaniaAdvanced Centre for Research-Development in Experimental Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, RomaniaAdvanced Centre for Research-Development in Experimental Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, RomaniaAdvanced Centre for Research-Development in Experimental Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, RomaniaPediatric Department, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, RomaniaDepartment of Internal Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Rheumatology and Physiotherapy, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, RomaniaAdvanced Centre for Research-Development in Experimental Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, RomaniaAdvanced Centre for Research-Development in Experimental Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, RomaniaViral infections are a major global health problem, representing a significant cause of mortality with an unfavorable continuously amplified socio-economic impact. The increased drug resistance and constant viral replication have been the trigger for important studies regarding the use of nanotechnology in antiviral therapies. Nanomaterials offer unique physico-chemical properties that have linked benefits for drug delivery as ideal tools for viral treatment. Currently, different types of nanomaterials namely nanoparticles, liposomes, nanospheres, nanogels, nanosuspensions and nanoemulsions were studied either in vitro or in vivo for drug delivery of antiviral agents with prospects to be translated in clinical practice. This review highlights the drug delivery nanosystems incorporating the major antiviral classes and their transport across specific barriers at cellular and intracellular level. Important reflections on nanomedicines currently approved or undergoing investigations for the treatment of viral infections are also discussed. Finally, the authors present an overview on the requirements for the design of antiviral nanotherapeutics.https://www.mdpi.com/1999-4923/12/2/171nanomaterialsantiviralsdrug deliverybiological barriers |
| spellingShingle | Florina-Daniela Cojocaru Doru Botezat Ioannis Gardikiotis Cristina-Mariana Uritu Gianina Dodi Laura Trandafir Ciprian Rezus Elena Rezus Bogdan-Ionel Tamba Cosmin-Teodor Mihai Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers Pharmaceutics nanomaterials antivirals drug delivery biological barriers |
| title | Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers |
| title_full | Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers |
| title_fullStr | Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers |
| title_full_unstemmed | Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers |
| title_short | Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers |
| title_sort | nanomaterials designed for antiviral drug delivery transport across biological barriers |
| topic | nanomaterials antivirals drug delivery biological barriers |
| url | https://www.mdpi.com/1999-4923/12/2/171 |
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