Long-Term Survival Effects of Preoperative Breast MRI in Patients with Breast-Conserving Surgery
The benefit of breast magnetic resonance imaging (MRI) in breast-conserving surgery (BCS) is unclear. Our study compared breast cancer patients with and without preoperative breast MRI and their long-term oncologic outcomes are reported. A total of 1378 BCS cases with early breast cancer between...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2022-01-01
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| Series: | Acta Clinica Croatica |
| Subjects: | |
| Online Access: | https://hrcak.srce.hr/file/405837 |
| _version_ | 1827282043642314752 |
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| author | Ahmet Serkan Ilgun Dauren Sarsenov Gul Alco Alper Ozturk Filiz Agacayak Filiz Elbuken Zeynep Erdogan Kezban Nur Pilanci Cetin Ordu Fatma Aktepe Gursel Soybir Vahit Ozmen |
| author_facet | Ahmet Serkan Ilgun Dauren Sarsenov Gul Alco Alper Ozturk Filiz Agacayak Filiz Elbuken Zeynep Erdogan Kezban Nur Pilanci Cetin Ordu Fatma Aktepe Gursel Soybir Vahit Ozmen |
| author_sort | Ahmet Serkan Ilgun |
| collection | DOAJ |
| description | The benefit of breast magnetic resonance imaging (MRI) in breast-conserving
surgery (BCS) is unclear. Our study compared breast cancer patients with and without preoperative
breast MRI and their long-term oncologic outcomes are reported. A total of 1378 BCS cases with early
breast cancer between 1996 and 2017 were reviewed. Patients with carcinoma in situ or neoadjuvant
treatment or having breast MRI after tumor excision were excluded. Of 1378 patients, 270 (19.5%)
had preoperative MRI. There were no significant differences regarding T and N stage and molecular
subtypes between the groups. Surgical margins were significantly wider in the breast MRI group.
Five-year overall survival (OS) was 96.9% in the MRI group and 94.3% in the control group, and
this difference was not significant (p=0.11). Five-year local-regional recurrence-free survival (LRFS)
was not significantly different either (98.8% and 96.5%, respectively, p=0.41). When analyses were
repeated only for patients with hormone receptor-negative or triple-negative breast cancer, there was
still no significant difference in OS, LRFS, or disease-free survival. In conclusion, MRI does not seem
necessary in all patients undergoing BCS. New prospective randomized controlled trials are needed to
determine appropriate use of preoperative MRI and its effects on oncologic outcomes in early breast
cancer patients. |
| first_indexed | 2024-04-24T09:11:25Z |
| format | Article |
| id | doaj.art-49c012c77ce44d38a3de008b0633df30 |
| institution | Directory Open Access Journal |
| issn | 0353-9466 1333-9451 |
| language | English |
| last_indexed | 2024-04-24T09:11:25Z |
| publishDate | 2022-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj.art-49c012c77ce44d38a3de008b0633df302024-04-15T17:50:05ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512022-01-0161.1.303710.20471/acc.2022.61.01.04Long-Term Survival Effects of Preoperative Breast MRI in Patients with Breast-Conserving SurgeryAhmet Serkan Ilgun0Dauren Sarsenov1Gul Alco2Alper Ozturk3Filiz Agacayak4Filiz Elbuken5Zeynep Erdogan6Kezban Nur Pilanci7Cetin Ordu8Fatma Aktepe9Gursel Soybir10Vahit Ozmen11Department of Surgery, Demiroglu Bilim University, Istanbul, TurkeyDepartment of Surgery, Mater Dei Hospital, Msida, MaltaDepartment of Radiation Oncology, Gayrettepe Florence Nightingale Hospital, Istanbul, TurkeyDepartment of Surgery, Biruni University Medical School, Istanbul, TurkeyDepartment of Radiology, Istanbul Florence Nightingale Hospital, Istanbul, TurkeyDepartment of Radiology, Yeditepe University Medical School, Istanbul, TurkeyPhysical Therapy and Rehabilitation Center, Biruni University Medical School, Istanbul, TurkeyDepartment of Medical Oncology, Memorial Bahcelievler Hospital, Istanbul, TurkeyDepartment of Medical Oncology, Gayrettepe Florence Nightingale Hospital, Istanbul, TurkeyDepartment of Pathology, Sisli Memorial Hospital, Istanbul, TurkeyDepartment of Surgery, Sisli Memorial Hospital, Istanbul, TurkeyDepartment of Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, TurkeyThe benefit of breast magnetic resonance imaging (MRI) in breast-conserving surgery (BCS) is unclear. Our study compared breast cancer patients with and without preoperative breast MRI and their long-term oncologic outcomes are reported. A total of 1378 BCS cases with early breast cancer between 1996 and 2017 were reviewed. Patients with carcinoma in situ or neoadjuvant treatment or having breast MRI after tumor excision were excluded. Of 1378 patients, 270 (19.5%) had preoperative MRI. There were no significant differences regarding T and N stage and molecular subtypes between the groups. Surgical margins were significantly wider in the breast MRI group. Five-year overall survival (OS) was 96.9% in the MRI group and 94.3% in the control group, and this difference was not significant (p=0.11). Five-year local-regional recurrence-free survival (LRFS) was not significantly different either (98.8% and 96.5%, respectively, p=0.41). When analyses were repeated only for patients with hormone receptor-negative or triple-negative breast cancer, there was still no significant difference in OS, LRFS, or disease-free survival. In conclusion, MRI does not seem necessary in all patients undergoing BCS. New prospective randomized controlled trials are needed to determine appropriate use of preoperative MRI and its effects on oncologic outcomes in early breast cancer patients.https://hrcak.srce.hr/file/405837Breast cancerBreast MRIBreast-conserving surgeryOverall survivalLocal failureOncologic outcome |
| spellingShingle | Ahmet Serkan Ilgun Dauren Sarsenov Gul Alco Alper Ozturk Filiz Agacayak Filiz Elbuken Zeynep Erdogan Kezban Nur Pilanci Cetin Ordu Fatma Aktepe Gursel Soybir Vahit Ozmen Long-Term Survival Effects of Preoperative Breast MRI in Patients with Breast-Conserving Surgery Acta Clinica Croatica Breast cancer Breast MRI Breast-conserving surgery Overall survival Local failure Oncologic outcome |
| title | Long-Term Survival Effects of Preoperative Breast MRI in Patients with Breast-Conserving Surgery |
| title_full | Long-Term Survival Effects of Preoperative Breast MRI in Patients with Breast-Conserving Surgery |
| title_fullStr | Long-Term Survival Effects of Preoperative Breast MRI in Patients with Breast-Conserving Surgery |
| title_full_unstemmed | Long-Term Survival Effects of Preoperative Breast MRI in Patients with Breast-Conserving Surgery |
| title_short | Long-Term Survival Effects of Preoperative Breast MRI in Patients with Breast-Conserving Surgery |
| title_sort | long term survival effects of preoperative breast mri in patients with breast conserving surgery |
| topic | Breast cancer Breast MRI Breast-conserving surgery Overall survival Local failure Oncologic outcome |
| url | https://hrcak.srce.hr/file/405837 |
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