dbEssLnc: A manually curated database of human and mouse essential lncRNA genes
Long non-coding RNAs (lncRNAs) play important roles in many biological processes. Knocking out or knocking down some lncRNAs will lead to lethality or infertility. These lncRNAs are called essential lncRNAs. Knowledges of essential lncRNAs are important in establishing minimal genomes of living cell...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Computational and Structural Biotechnology Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037022001982 |
| _version_ | 1797978212993597440 |
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| author | Ying-Ying Zhang Wen-Ya Zhang Xiao-Hong Xin Pu-Feng Du |
| author_facet | Ying-Ying Zhang Wen-Ya Zhang Xiao-Hong Xin Pu-Feng Du |
| author_sort | Ying-Ying Zhang |
| collection | DOAJ |
| description | Long non-coding RNAs (lncRNAs) play important roles in many biological processes. Knocking out or knocking down some lncRNAs will lead to lethality or infertility. These lncRNAs are called essential lncRNAs. Knowledges of essential lncRNAs are important in establishing minimal genomes of living cells, developing drug therapies and early diagnostic approaches for complex diseases. However, existing databases focus on collecting essential coding genes. Essential non-coding gene records are rare in existing databases. A comprehensive collection of essential non-coding genes, particularly essential lncRNA genes, is demanded. We manually curated 207 essential lncRNAs from literatures for establishing a database on essential lncRNAs, which is named as dbEssLnc (Database of essential lncRNAs). The dbEssLnc database has a web-based user-friendly interface for the users to browse, to search, to visualize and to blast search records in the database. The dbEssLnc database is freely accessible at https://esslnc.pufengdu.org. All data and source codes for mirroring the dbEssLnc database have been deposited in GitHub (https://github.com/yyZhang14/dbEssLnc). |
| first_indexed | 2024-04-11T05:19:24Z |
| format | Article |
| id | doaj.art-49c0571a2f7f4c18b57f1e46c39eb88d |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-04-11T05:19:24Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-49c0571a2f7f4c18b57f1e46c39eb88d2022-12-24T04:52:40ZengElsevierComputational and Structural Biotechnology Journal2001-03702022-01-012026572663dbEssLnc: A manually curated database of human and mouse essential lncRNA genesYing-Ying Zhang0Wen-Ya Zhang1Xiao-Hong Xin2Pu-Feng Du3College of Intelligence and Computing, Tianjin University, Tianjin 300350, ChinaCollege of Intelligence and Computing, Tianjin University, Tianjin 300350, ChinaCollege of Intelligence and Computing, Tianjin University, Tianjin 300350, ChinaCorresponding author.; College of Intelligence and Computing, Tianjin University, Tianjin 300350, ChinaLong non-coding RNAs (lncRNAs) play important roles in many biological processes. Knocking out or knocking down some lncRNAs will lead to lethality or infertility. These lncRNAs are called essential lncRNAs. Knowledges of essential lncRNAs are important in establishing minimal genomes of living cells, developing drug therapies and early diagnostic approaches for complex diseases. However, existing databases focus on collecting essential coding genes. Essential non-coding gene records are rare in existing databases. A comprehensive collection of essential non-coding genes, particularly essential lncRNA genes, is demanded. We manually curated 207 essential lncRNAs from literatures for establishing a database on essential lncRNAs, which is named as dbEssLnc (Database of essential lncRNAs). The dbEssLnc database has a web-based user-friendly interface for the users to browse, to search, to visualize and to blast search records in the database. The dbEssLnc database is freely accessible at https://esslnc.pufengdu.org. All data and source codes for mirroring the dbEssLnc database have been deposited in GitHub (https://github.com/yyZhang14/dbEssLnc).http://www.sciencedirect.com/science/article/pii/S2001037022001982Essential lncRNADatabaseKnockoutKnockdowndbEssLnc |
| spellingShingle | Ying-Ying Zhang Wen-Ya Zhang Xiao-Hong Xin Pu-Feng Du dbEssLnc: A manually curated database of human and mouse essential lncRNA genes Computational and Structural Biotechnology Journal Essential lncRNA Database Knockout Knockdown dbEssLnc |
| title | dbEssLnc: A manually curated database of human and mouse essential lncRNA genes |
| title_full | dbEssLnc: A manually curated database of human and mouse essential lncRNA genes |
| title_fullStr | dbEssLnc: A manually curated database of human and mouse essential lncRNA genes |
| title_full_unstemmed | dbEssLnc: A manually curated database of human and mouse essential lncRNA genes |
| title_short | dbEssLnc: A manually curated database of human and mouse essential lncRNA genes |
| title_sort | dbesslnc a manually curated database of human and mouse essential lncrna genes |
| topic | Essential lncRNA Database Knockout Knockdown dbEssLnc |
| url | http://www.sciencedirect.com/science/article/pii/S2001037022001982 |
| work_keys_str_mv | AT yingyingzhang dbesslncamanuallycurateddatabaseofhumanandmouseessentiallncrnagenes AT wenyazhang dbesslncamanuallycurateddatabaseofhumanandmouseessentiallncrnagenes AT xiaohongxin dbesslncamanuallycurateddatabaseofhumanandmouseessentiallncrnagenes AT pufengdu dbesslncamanuallycurateddatabaseofhumanandmouseessentiallncrnagenes |