Bifidobacterium lactis Probio-M8 relieved acute respiratory tract infections in children possibly by modulating the gut microbes and metabolites
Respiratory tract infections constitute a significant global public health concern, accounting for around 20 % of child fatalities worldwide. Modulating the gut microbiota have the potential to serve as a promising strategy for both the prevention and treatment of respiratory infections. According t...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624001130 |
| _version_ | 1797256407766007808 |
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| author | Yalin Li Xuan Shi Teng Ma Weiwei Hu Hao Jin Heping Zhang Min‑Tze Liong Zhihong Sun |
| author_facet | Yalin Li Xuan Shi Teng Ma Weiwei Hu Hao Jin Heping Zhang Min‑Tze Liong Zhihong Sun |
| author_sort | Yalin Li |
| collection | DOAJ |
| description | Respiratory tract infections constitute a significant global public health concern, accounting for around 20 % of child fatalities worldwide. Modulating the gut microbiota have the potential to serve as a promising strategy for both the prevention and treatment of respiratory infections. According to our prior research, the consumption of Bifidobacterium lactis Probio-M8 can notably enhance symptoms associated with respiratory tract infections in infants and young children. The current study is a follow-up work aimed at exploring the functional role of the gut microbes in the observed beneficial effects. We analyzed the fecal metagenomes of patients in both the probiotic group (n = 50) and the placebo group (n = 49). The results showed that Probio-M8 intervention may regulate the host inflammatory response by regulating the balance of intestinal microorganisms, bioactive metabolites and related pathways. Provides new insights into the study of probiotics in alleviating diseases related to the gut-lung axis. |
| first_indexed | 2024-04-24T22:21:16Z |
| format | Article |
| id | doaj.art-49c06161d03c43819d43112668128a83 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-24T22:21:16Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-49c06161d03c43819d43112668128a832024-03-20T06:09:07ZengElsevierJournal of Functional Foods1756-46462024-04-01115106111Bifidobacterium lactis Probio-M8 relieved acute respiratory tract infections in children possibly by modulating the gut microbes and metabolitesYalin Li0Xuan Shi1Teng Ma2Weiwei Hu3Hao Jin4Heping Zhang5Min‑Tze Liong6Zhihong Sun7Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China; Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, ChinaInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China; Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, ChinaInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China; Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, ChinaInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China; Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, ChinaInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China; Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, ChinaInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China; Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, ChinaSchool of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia; Corresponding authors.Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China; Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China; Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China; Corresponding authors.Respiratory tract infections constitute a significant global public health concern, accounting for around 20 % of child fatalities worldwide. Modulating the gut microbiota have the potential to serve as a promising strategy for both the prevention and treatment of respiratory infections. According to our prior research, the consumption of Bifidobacterium lactis Probio-M8 can notably enhance symptoms associated with respiratory tract infections in infants and young children. The current study is a follow-up work aimed at exploring the functional role of the gut microbes in the observed beneficial effects. We analyzed the fecal metagenomes of patients in both the probiotic group (n = 50) and the placebo group (n = 49). The results showed that Probio-M8 intervention may regulate the host inflammatory response by regulating the balance of intestinal microorganisms, bioactive metabolites and related pathways. Provides new insights into the study of probiotics in alleviating diseases related to the gut-lung axis.http://www.sciencedirect.com/science/article/pii/S1756464624001130Respiratory tract infectionsBifidobacterium lactis Probio-M8ChildrenGut microbiotaSpecies-level genome bins |
| spellingShingle | Yalin Li Xuan Shi Teng Ma Weiwei Hu Hao Jin Heping Zhang Min‑Tze Liong Zhihong Sun Bifidobacterium lactis Probio-M8 relieved acute respiratory tract infections in children possibly by modulating the gut microbes and metabolites Journal of Functional Foods Respiratory tract infections Bifidobacterium lactis Probio-M8 Children Gut microbiota Species-level genome bins |
| title | Bifidobacterium lactis Probio-M8 relieved acute respiratory tract infections in children possibly by modulating the gut microbes and metabolites |
| title_full | Bifidobacterium lactis Probio-M8 relieved acute respiratory tract infections in children possibly by modulating the gut microbes and metabolites |
| title_fullStr | Bifidobacterium lactis Probio-M8 relieved acute respiratory tract infections in children possibly by modulating the gut microbes and metabolites |
| title_full_unstemmed | Bifidobacterium lactis Probio-M8 relieved acute respiratory tract infections in children possibly by modulating the gut microbes and metabolites |
| title_short | Bifidobacterium lactis Probio-M8 relieved acute respiratory tract infections in children possibly by modulating the gut microbes and metabolites |
| title_sort | bifidobacterium lactis probio m8 relieved acute respiratory tract infections in children possibly by modulating the gut microbes and metabolites |
| topic | Respiratory tract infections Bifidobacterium lactis Probio-M8 Children Gut microbiota Species-level genome bins |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624001130 |
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