Delayed diagnosis of pituitary stalk interruption syndrome with severe recurrent hyponatremia caused by adrenal insufficiency
Pituitary stalk interruption syndrome (PSIS) involves the occurrence of a thin or absent pituitary stalk, hypoplasia of the adenohypophysis, and ectopic neurohypophysis. Diagnosis is confirmed using magnetic resonance imaging. Patients with PSIS have a variable degree of pituitary hormone deficiency...
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| Format: | Article |
| Language: | English |
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Korean Society of Pediatric Endocrinology
2017-09-01
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| Series: | Annals of Pediatric Endocrinology & Metabolism |
| Subjects: | |
| Online Access: | http://e-apem.org/upload/pdf/apem-2017-22-3-208.pdf |
| _version_ | 1818671974336954368 |
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| author | Kyung Mi Jang Cheol Woo Ko |
| author_facet | Kyung Mi Jang Cheol Woo Ko |
| author_sort | Kyung Mi Jang |
| collection | DOAJ |
| description | Pituitary stalk interruption syndrome (PSIS) involves the occurrence of a thin or absent pituitary stalk, hypoplasia of the adenohypophysis, and ectopic neurohypophysis. Diagnosis is confirmed using magnetic resonance imaging. Patients with PSIS have a variable degree of pituitary hormone deficiency and a wide spectrum of clinical manifestations. The clinical course of the disease in our patient is similar to that of a syndrome of inappropriate antidiuretic hormone secretion. This is thought to be caused by failure in the suppression of vasopressin secretion due to hypocortisolism. To the best of our knowledge, there is no case report of a patient with PSIS presenting with hyponatremia as the first symptom in Korean children. Herein, we report a patient with PSIS presenting severe recurrent hyponatremia as the first symptom, during adolescence and explain the pathophysiology of hyponatremia with secondary adrenal insufficiency. |
| first_indexed | 2024-12-17T07:32:31Z |
| format | Article |
| id | doaj.art-49c19b5bb43742aabe09b318ec61c217 |
| institution | Directory Open Access Journal |
| issn | 2287-1012 2287-1292 |
| language | English |
| last_indexed | 2024-12-17T07:32:31Z |
| publishDate | 2017-09-01 |
| publisher | Korean Society of Pediatric Endocrinology |
| record_format | Article |
| series | Annals of Pediatric Endocrinology & Metabolism |
| spelling | doaj.art-49c19b5bb43742aabe09b318ec61c2172022-12-21T21:58:26ZengKorean Society of Pediatric EndocrinologyAnnals of Pediatric Endocrinology & Metabolism2287-10122287-12922017-09-0122320821210.6065/apem.2017.22.3.208704Delayed diagnosis of pituitary stalk interruption syndrome with severe recurrent hyponatremia caused by adrenal insufficiencyKyung Mi Jang0Cheol Woo Ko1 Department of Pediatrics, Yeungnam University College of Medicine, Daegu, Korea Department of Pediatric Endocrinology, Kyungpook National University Children’s Hospital, Daegu, KoreaPituitary stalk interruption syndrome (PSIS) involves the occurrence of a thin or absent pituitary stalk, hypoplasia of the adenohypophysis, and ectopic neurohypophysis. Diagnosis is confirmed using magnetic resonance imaging. Patients with PSIS have a variable degree of pituitary hormone deficiency and a wide spectrum of clinical manifestations. The clinical course of the disease in our patient is similar to that of a syndrome of inappropriate antidiuretic hormone secretion. This is thought to be caused by failure in the suppression of vasopressin secretion due to hypocortisolism. To the best of our knowledge, there is no case report of a patient with PSIS presenting with hyponatremia as the first symptom in Korean children. Herein, we report a patient with PSIS presenting severe recurrent hyponatremia as the first symptom, during adolescence and explain the pathophysiology of hyponatremia with secondary adrenal insufficiency.http://e-apem.org/upload/pdf/apem-2017-22-3-208.pdfPituitary stalk interruption syndromeHyponatremiaHypopituitarismInappropriate ADH syndromeAdrenal insufficiency |
| spellingShingle | Kyung Mi Jang Cheol Woo Ko Delayed diagnosis of pituitary stalk interruption syndrome with severe recurrent hyponatremia caused by adrenal insufficiency Annals of Pediatric Endocrinology & Metabolism Pituitary stalk interruption syndrome Hyponatremia Hypopituitarism Inappropriate ADH syndrome Adrenal insufficiency |
| title | Delayed diagnosis of pituitary stalk interruption syndrome with severe recurrent hyponatremia caused by adrenal insufficiency |
| title_full | Delayed diagnosis of pituitary stalk interruption syndrome with severe recurrent hyponatremia caused by adrenal insufficiency |
| title_fullStr | Delayed diagnosis of pituitary stalk interruption syndrome with severe recurrent hyponatremia caused by adrenal insufficiency |
| title_full_unstemmed | Delayed diagnosis of pituitary stalk interruption syndrome with severe recurrent hyponatremia caused by adrenal insufficiency |
| title_short | Delayed diagnosis of pituitary stalk interruption syndrome with severe recurrent hyponatremia caused by adrenal insufficiency |
| title_sort | delayed diagnosis of pituitary stalk interruption syndrome with severe recurrent hyponatremia caused by adrenal insufficiency |
| topic | Pituitary stalk interruption syndrome Hyponatremia Hypopituitarism Inappropriate ADH syndrome Adrenal insufficiency |
| url | http://e-apem.org/upload/pdf/apem-2017-22-3-208.pdf |
| work_keys_str_mv | AT kyungmijang delayeddiagnosisofpituitarystalkinterruptionsyndromewithsevererecurrenthyponatremiacausedbyadrenalinsufficiency AT cheolwooko delayeddiagnosisofpituitarystalkinterruptionsyndromewithsevererecurrenthyponatremiacausedbyadrenalinsufficiency |