Phase angle by electrical bioimpedance is a predictive factor of hospitalisation, falls and mortality in patients with cirrhosis
Abstract The phase angle is a versatile measurement to assess body composition, frailty and prognosis in patients with chronic diseases. In cirrhosis, patients often present alterations in body composition that are related to adverse outcomes. The phase angle could be useful to evaluate prognosis in...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-99199-8 |
| _version_ | 1819022661906333696 |
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| author | Eva Román Maria Poca Gerard Amorós-Figueras Javier Rosell-Ferrer Cristina Gely Juan C. Nieto Silvia Vidal Eulàlia Urgell Andreu Ferrero-Gregori Edilmar Alvarado-Tapias Berta Cuyàs Elvira Hernández Rosalia Santesmases Carlos Guarner Àngels Escorsell German Soriano |
| author_facet | Eva Román Maria Poca Gerard Amorós-Figueras Javier Rosell-Ferrer Cristina Gely Juan C. Nieto Silvia Vidal Eulàlia Urgell Andreu Ferrero-Gregori Edilmar Alvarado-Tapias Berta Cuyàs Elvira Hernández Rosalia Santesmases Carlos Guarner Àngels Escorsell German Soriano |
| author_sort | Eva Román |
| collection | DOAJ |
| description | Abstract The phase angle is a versatile measurement to assess body composition, frailty and prognosis in patients with chronic diseases. In cirrhosis, patients often present alterations in body composition that are related to adverse outcomes. The phase angle could be useful to evaluate prognosis in these patients, but data are scarce. The aim was to analyse the prognostic value of the phase angle to predict clinically relevant events such as hospitalisation, falls, and mortality in patients with cirrhosis. Outpatients with cirrhosis were consecutively included and the phase angle was determined by electrical bioimpedance. Patients were prospectively followed to determine the incidence of hospitalisations, falls, and mortality. One hundred patients were included. Patients with phase angle ≤ 4.6° (n = 31) showed a higher probability of hospitalisation (35% vs 11%, p = 0.003), falls (41% vs 11%, p = 0.001) and mortality (26% vs 3%, p = 0.001) at 2-year follow-up than patients with PA > 4.6° (n = 69). In the multivariable analysis, the phase angle and MELD-Na were independent predictive factors of hospitalisation and mortality. Phase angle was the only predictive factor for falls. In conclusion, the phase angle showed to be a predictive marker for hospitalisation, falls, and mortality in outpatients with cirrhosis. |
| first_indexed | 2024-12-21T04:26:33Z |
| format | Article |
| id | doaj.art-49c1a30ef33b4891baabf0b387514954 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-21T04:26:33Z |
| publishDate | 2021-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-49c1a30ef33b4891baabf0b3875149542022-12-21T19:16:03ZengNature PortfolioScientific Reports2045-23222021-10-0111111110.1038/s41598-021-99199-8Phase angle by electrical bioimpedance is a predictive factor of hospitalisation, falls and mortality in patients with cirrhosisEva Román0Maria Poca1Gerard Amorós-Figueras2Javier Rosell-Ferrer3Cristina Gely4Juan C. Nieto5Silvia Vidal6Eulàlia Urgell7Andreu Ferrero-Gregori8Edilmar Alvarado-Tapias9Berta Cuyàs10Elvira Hernández11Rosalia Santesmases12Carlos Guarner13Àngels Escorsell14German Soriano15Escola Universitària d’Infermeria EUI-Sant PauDepartment of Gastroenterology, Hospital de la Santa Creu i Sant PauDepartment of Cardiology, Hospital de la Santa Creu i Sant PauDepartment of Electronic Engineering, Universitat Politècnica de CatalunyaResearch Institute IIB-Sant PauResearch Institute IIB-Sant PauDepartment of Immunology, Hospital de la Santa Creu i Sant PauDepartment of Biochemistry, Hospital de la Santa Creu i Sant PauINCLIVA Health Research InstituteDepartment of Gastroenterology, Hospital de la Santa Creu i Sant PauDepartment of Gastroenterology, Hospital de la Santa Creu i Sant PauEscola Universitària d’Infermeria EUI-Sant PauEscola Universitària d’Infermeria EUI-Sant PauDepartment of Gastroenterology, Hospital de la Santa Creu i Sant PauDepartment of Gastroenterology, Hospital de la Santa Creu i Sant PauDepartment of Gastroenterology, Hospital de la Santa Creu i Sant PauAbstract The phase angle is a versatile measurement to assess body composition, frailty and prognosis in patients with chronic diseases. In cirrhosis, patients often present alterations in body composition that are related to adverse outcomes. The phase angle could be useful to evaluate prognosis in these patients, but data are scarce. The aim was to analyse the prognostic value of the phase angle to predict clinically relevant events such as hospitalisation, falls, and mortality in patients with cirrhosis. Outpatients with cirrhosis were consecutively included and the phase angle was determined by electrical bioimpedance. Patients were prospectively followed to determine the incidence of hospitalisations, falls, and mortality. One hundred patients were included. Patients with phase angle ≤ 4.6° (n = 31) showed a higher probability of hospitalisation (35% vs 11%, p = 0.003), falls (41% vs 11%, p = 0.001) and mortality (26% vs 3%, p = 0.001) at 2-year follow-up than patients with PA > 4.6° (n = 69). In the multivariable analysis, the phase angle and MELD-Na were independent predictive factors of hospitalisation and mortality. Phase angle was the only predictive factor for falls. In conclusion, the phase angle showed to be a predictive marker for hospitalisation, falls, and mortality in outpatients with cirrhosis.https://doi.org/10.1038/s41598-021-99199-8 |
| spellingShingle | Eva Román Maria Poca Gerard Amorós-Figueras Javier Rosell-Ferrer Cristina Gely Juan C. Nieto Silvia Vidal Eulàlia Urgell Andreu Ferrero-Gregori Edilmar Alvarado-Tapias Berta Cuyàs Elvira Hernández Rosalia Santesmases Carlos Guarner Àngels Escorsell German Soriano Phase angle by electrical bioimpedance is a predictive factor of hospitalisation, falls and mortality in patients with cirrhosis Scientific Reports |
| title | Phase angle by electrical bioimpedance is a predictive factor of hospitalisation, falls and mortality in patients with cirrhosis |
| title_full | Phase angle by electrical bioimpedance is a predictive factor of hospitalisation, falls and mortality in patients with cirrhosis |
| title_fullStr | Phase angle by electrical bioimpedance is a predictive factor of hospitalisation, falls and mortality in patients with cirrhosis |
| title_full_unstemmed | Phase angle by electrical bioimpedance is a predictive factor of hospitalisation, falls and mortality in patients with cirrhosis |
| title_short | Phase angle by electrical bioimpedance is a predictive factor of hospitalisation, falls and mortality in patients with cirrhosis |
| title_sort | phase angle by electrical bioimpedance is a predictive factor of hospitalisation falls and mortality in patients with cirrhosis |
| url | https://doi.org/10.1038/s41598-021-99199-8 |
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