?-Fluoro-Benzylphosphonates as Reagents for the Preparation of 1-Fluoro-1-Aryl Alkenes and ?-Fluorostilbenes

The preparation of several fluoro-benzylphosphonates Ar-CHF-PO(OEt)2 and their Wadsworth-Emmons type olefination with aldehydes and ketones are described affording fluorostyrenes and fluorostilbenes. Some of these compounds are incorporated into target molecules tested as drug candidates....

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Autors principals: Thomas Allmendinger, Roger Fujimoto, Fabrizio Gasparini, Walter Schilling, Yoshi Satoh
Format: Article
Idioma:deu
Publicat: Swiss Chemical Society 2004-03-01
Col·lecció:CHIMIA
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Accés en línia:https://chimia.ch/chimia/article/view/3818