Experience of switching from a daily to a less frequent administration of injection treatments.
<h4>Background</h4>Daily injections of recombinant human growth hormone are the standard of care to treat growth failure due to pediatric growth hormone deficiency (GHD). While effective, daily injections are burdensome and can compromise adherence. In recent years, novel injection treat...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0278293 |
| _version_ | 1797958109823500288 |
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| author | Jane Loftus Andrew Yaworsky Carl L Roland Diane Turner-Bowker Megan McLafferty Sylvia Su Roger E Lamoureux |
| author_facet | Jane Loftus Andrew Yaworsky Carl L Roland Diane Turner-Bowker Megan McLafferty Sylvia Su Roger E Lamoureux |
| author_sort | Jane Loftus |
| collection | DOAJ |
| description | <h4>Background</h4>Daily injections of recombinant human growth hormone are the standard of care to treat growth failure due to pediatric growth hormone deficiency (GHD). While effective, daily injections are burdensome and can compromise adherence. In recent years, novel injection treatments requiring less frequent administration for growth hormone deficiency (GHD) have been developed. A targeted, pragmatic literature review was conducted to summarize and document the patient experience of moving from daily to less frequent injections, with a specific focus on changing from daily to weekly injection treatments in pediatric GHD (pGHD).<h4>Objective</h4>Explore and describe the patient experience when switching from a daily to a less frequent injection schedule for GHD.<h4>Methods</h4>Targeted literature searches were conducted to identify literature describing the patient experience of moving from a daily to weekly injection in GHD. Supplementary searches were conducted to identify literature describing the patient experience of moving from daily to less frequent injection regimens in other medical conditions.<h4>Results</h4>Across searches, 1,691 abstracts were reviewed and 13 articles were included in the final analysis. These publications reported that patients moving to less frequent injections across a variety of conditions, including GHD, experienced increased convenience and satisfaction, higher adherence rates, fewer adverse events, and improved quality of life. Less frequent injections were also reported to be at least as efficacious as daily treatments.<h4>Conclusions</h4>Less frequent injections in GHD and as other conditions are less burdensome, positively benefit patients, and result in improved adherence that may lead to improved clinical outcomes. Clinicians may consider weekly regimens as an effective alternative for patients, in particular in pGHD, especially when missed injections can negatively impact treatment outcomes. More research is needed to better understand the real-world benefits of injectable therapies that require less frequent administration (e.g., weekly versus daily). |
| first_indexed | 2024-04-11T00:14:08Z |
| format | Article |
| id | doaj.art-49c3dccce5c54f34af8051c9443f1e9a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T00:14:08Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-49c3dccce5c54f34af8051c9443f1e9a2023-01-09T05:31:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-011711e027829310.1371/journal.pone.0278293Experience of switching from a daily to a less frequent administration of injection treatments.Jane LoftusAndrew YaworskyCarl L RolandDiane Turner-BowkerMegan McLaffertySylvia SuRoger E Lamoureux<h4>Background</h4>Daily injections of recombinant human growth hormone are the standard of care to treat growth failure due to pediatric growth hormone deficiency (GHD). While effective, daily injections are burdensome and can compromise adherence. In recent years, novel injection treatments requiring less frequent administration for growth hormone deficiency (GHD) have been developed. A targeted, pragmatic literature review was conducted to summarize and document the patient experience of moving from daily to less frequent injections, with a specific focus on changing from daily to weekly injection treatments in pediatric GHD (pGHD).<h4>Objective</h4>Explore and describe the patient experience when switching from a daily to a less frequent injection schedule for GHD.<h4>Methods</h4>Targeted literature searches were conducted to identify literature describing the patient experience of moving from a daily to weekly injection in GHD. Supplementary searches were conducted to identify literature describing the patient experience of moving from daily to less frequent injection regimens in other medical conditions.<h4>Results</h4>Across searches, 1,691 abstracts were reviewed and 13 articles were included in the final analysis. These publications reported that patients moving to less frequent injections across a variety of conditions, including GHD, experienced increased convenience and satisfaction, higher adherence rates, fewer adverse events, and improved quality of life. Less frequent injections were also reported to be at least as efficacious as daily treatments.<h4>Conclusions</h4>Less frequent injections in GHD and as other conditions are less burdensome, positively benefit patients, and result in improved adherence that may lead to improved clinical outcomes. Clinicians may consider weekly regimens as an effective alternative for patients, in particular in pGHD, especially when missed injections can negatively impact treatment outcomes. More research is needed to better understand the real-world benefits of injectable therapies that require less frequent administration (e.g., weekly versus daily).https://doi.org/10.1371/journal.pone.0278293 |
| spellingShingle | Jane Loftus Andrew Yaworsky Carl L Roland Diane Turner-Bowker Megan McLafferty Sylvia Su Roger E Lamoureux Experience of switching from a daily to a less frequent administration of injection treatments. PLoS ONE |
| title | Experience of switching from a daily to a less frequent administration of injection treatments. |
| title_full | Experience of switching from a daily to a less frequent administration of injection treatments. |
| title_fullStr | Experience of switching from a daily to a less frequent administration of injection treatments. |
| title_full_unstemmed | Experience of switching from a daily to a less frequent administration of injection treatments. |
| title_short | Experience of switching from a daily to a less frequent administration of injection treatments. |
| title_sort | experience of switching from a daily to a less frequent administration of injection treatments |
| url | https://doi.org/10.1371/journal.pone.0278293 |
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