Paget's disease of bone presenting with multiple cranial nerve palsies: A case report
Paget's disease of bone (PDB) is a progressive monostotic or polyostotic osteopathy with unknown cause. It is associated with the involvement of the nervous system. The cranial nerves, spinal roots, cauda equina, spinal cord, and brain can be affected in PDB due to their close anatomical relati...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-06-01
|
| Series: | Radiology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043322002060 |
| _version_ | 1818187551144411136 |
|---|---|
| author | M. Hamid, MD F. Touarsa, MD A. Satte, MD A. Bourazza, MD |
| author_facet | M. Hamid, MD F. Touarsa, MD A. Satte, MD A. Bourazza, MD |
| author_sort | M. Hamid, MD |
| collection | DOAJ |
| description | Paget's disease of bone (PDB) is a progressive monostotic or polyostotic osteopathy with unknown cause. It is associated with the involvement of the nervous system. The cranial nerves, spinal roots, cauda equina, spinal cord, and brain can be affected in PDB due to their close anatomical relation to bone. Hearing loss occurs in 12%-50% of patients with PDB. The optic nerve can be affected at the optic canal. The diagnosis of PDB is radiological by highlighting characteristic lesions like thickening of the cortical bone, hypertrophic and fibrillary bones. Progressive or chronic neurological deficits should be treated with bisphosphonates. We present a rare case of multiple cranial nerve palsies as the first manifestation of PDB. |
| first_indexed | 2024-12-11T23:12:49Z |
| format | Article |
| id | doaj.art-49c56425eb7e40429cfc49e418edf44a |
| institution | Directory Open Access Journal |
| issn | 1930-0433 |
| language | English |
| last_indexed | 2024-12-11T23:12:49Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj.art-49c56425eb7e40429cfc49e418edf44a2022-12-22T00:46:39ZengElsevierRadiology Case Reports1930-04332022-06-0117618701873Paget's disease of bone presenting with multiple cranial nerve palsies: A case reportM. Hamid, MD0F. Touarsa, MD1A. Satte, MD2A. Bourazza, MD3Department of Neurology, Mohammed V Military Instruction Hospital, Rabat Morocco; Corresponding author.Department of Radiology, Avicenna University Hospital, Rabat MoroccoDepartment of Neurology, Mohammed V Military Instruction Hospital, Rabat MoroccoDepartment of Neurology, Mohammed V Military Instruction Hospital, Rabat MoroccoPaget's disease of bone (PDB) is a progressive monostotic or polyostotic osteopathy with unknown cause. It is associated with the involvement of the nervous system. The cranial nerves, spinal roots, cauda equina, spinal cord, and brain can be affected in PDB due to their close anatomical relation to bone. Hearing loss occurs in 12%-50% of patients with PDB. The optic nerve can be affected at the optic canal. The diagnosis of PDB is radiological by highlighting characteristic lesions like thickening of the cortical bone, hypertrophic and fibrillary bones. Progressive or chronic neurological deficits should be treated with bisphosphonates. We present a rare case of multiple cranial nerve palsies as the first manifestation of PDB.http://www.sciencedirect.com/science/article/pii/S1930043322002060Paget's disease of boneMultiple cranial nerve palsiesSphenoid boneBisphosphonates |
| spellingShingle | M. Hamid, MD F. Touarsa, MD A. Satte, MD A. Bourazza, MD Paget's disease of bone presenting with multiple cranial nerve palsies: A case report Radiology Case Reports Paget's disease of bone Multiple cranial nerve palsies Sphenoid bone Bisphosphonates |
| title | Paget's disease of bone presenting with multiple cranial nerve palsies: A case report |
| title_full | Paget's disease of bone presenting with multiple cranial nerve palsies: A case report |
| title_fullStr | Paget's disease of bone presenting with multiple cranial nerve palsies: A case report |
| title_full_unstemmed | Paget's disease of bone presenting with multiple cranial nerve palsies: A case report |
| title_short | Paget's disease of bone presenting with multiple cranial nerve palsies: A case report |
| title_sort | paget s disease of bone presenting with multiple cranial nerve palsies a case report |
| topic | Paget's disease of bone Multiple cranial nerve palsies Sphenoid bone Bisphosphonates |
| url | http://www.sciencedirect.com/science/article/pii/S1930043322002060 |
| work_keys_str_mv | AT mhamidmd pagetsdiseaseofbonepresentingwithmultiplecranialnervepalsiesacasereport AT ftouarsamd pagetsdiseaseofbonepresentingwithmultiplecranialnervepalsiesacasereport AT asattemd pagetsdiseaseofbonepresentingwithmultiplecranialnervepalsiesacasereport AT abourazzamd pagetsdiseaseofbonepresentingwithmultiplecranialnervepalsiesacasereport |