Ozone oxidation of antidepressants in wastewater –Treatment evaluation and characterization of new by-products by LC-QToFMS
<p>Abstract</p> <p>Background</p> <p>The fate of 14 antidepressants along with their respective <it>N</it>-desmethyl metabolites and the anticonvulsive drug carbamazepine was examined in a primary sewage treatment plant (STP) and following advanced treatment...
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| Format: | Article |
| Language: | English |
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BMC
2013-01-01
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| Series: | Chemistry Central Journal |
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| Online Access: | http://journal.chemistrycentral.com/content/7/1/15 |
| _version_ | 1818778807061970944 |
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| author | Lajeunesse André Blais Mireille Barbeau Benoît Sauvé Sébastien Gagnon Christian |
| author_facet | Lajeunesse André Blais Mireille Barbeau Benoît Sauvé Sébastien Gagnon Christian |
| author_sort | Lajeunesse André |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The fate of 14 antidepressants along with their respective <it>N</it>-desmethyl metabolites and the anticonvulsive drug carbamazepine was examined in a primary sewage treatment plant (STP) and following advanced treatments with ozone (O<sub>3</sub>). The concentrations of each pharmaceutical compound were determined in raw sewage, effluent and sewage sludge samples by LC-MS/MS analysis. The occurrence of antidepressant by-products formed in treated effluent after ozonation was also investigated.</p> <p>Results</p> <p>Current primary treatments using physical and chemical processes removed little of the compounds (mean removal efficiency: 19%). Experimental sorption coefficients (K<sub>d</sub>) of each studied compounds were also calculated. Sorption of venlafaxine, desmethylvenlafaxine, and carbamazepine on sludge was assumed to be negligible (log K<sub>d</sub> ≤ 2), but higher sorption behavior can be expected for sertraline (log K<sub>d</sub> ≥ 4). Ozonation treatment with O<sub>3</sub> (5 mg/L) led to a satisfactory mean removal efficiency of 88% of the compounds. Screening of the final ozone-treated effluent samples by high resolution-mass spectrometry (LC-QqToFMS) did confirm the presence of related <it>N</it>-oxide by-products.</p> <p>Conclusion</p> <p>Effluent ozonation led to higher mean removal efficiencies than current primary treatment, and therefore represented a promising strategy for the elimination of antidepressants in urban wastewaters. However, the use of O<sub>3</sub> produced by-products with unknown toxicity.</p> |
| first_indexed | 2024-12-18T11:50:35Z |
| format | Article |
| id | doaj.art-49c59e9c5089473b81d09da4c03d754e |
| institution | Directory Open Access Journal |
| issn | 1752-153X |
| language | English |
| last_indexed | 2024-12-18T11:50:35Z |
| publishDate | 2013-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Chemistry Central Journal |
| spelling | doaj.art-49c59e9c5089473b81d09da4c03d754e2022-12-21T21:09:10ZengBMCChemistry Central Journal1752-153X2013-01-01711510.1186/1752-153X-7-15Ozone oxidation of antidepressants in wastewater –Treatment evaluation and characterization of new by-products by LC-QToFMSLajeunesse AndréBlais MireilleBarbeau BenoîtSauvé SébastienGagnon Christian<p>Abstract</p> <p>Background</p> <p>The fate of 14 antidepressants along with their respective <it>N</it>-desmethyl metabolites and the anticonvulsive drug carbamazepine was examined in a primary sewage treatment plant (STP) and following advanced treatments with ozone (O<sub>3</sub>). The concentrations of each pharmaceutical compound were determined in raw sewage, effluent and sewage sludge samples by LC-MS/MS analysis. The occurrence of antidepressant by-products formed in treated effluent after ozonation was also investigated.</p> <p>Results</p> <p>Current primary treatments using physical and chemical processes removed little of the compounds (mean removal efficiency: 19%). Experimental sorption coefficients (K<sub>d</sub>) of each studied compounds were also calculated. Sorption of venlafaxine, desmethylvenlafaxine, and carbamazepine on sludge was assumed to be negligible (log K<sub>d</sub> ≤ 2), but higher sorption behavior can be expected for sertraline (log K<sub>d</sub> ≥ 4). Ozonation treatment with O<sub>3</sub> (5 mg/L) led to a satisfactory mean removal efficiency of 88% of the compounds. Screening of the final ozone-treated effluent samples by high resolution-mass spectrometry (LC-QqToFMS) did confirm the presence of related <it>N</it>-oxide by-products.</p> <p>Conclusion</p> <p>Effluent ozonation led to higher mean removal efficiencies than current primary treatment, and therefore represented a promising strategy for the elimination of antidepressants in urban wastewaters. However, the use of O<sub>3</sub> produced by-products with unknown toxicity.</p>http://journal.chemistrycentral.com/content/7/1/15AntidepressantsOzoneLC-MS/MSSewage treatment plantsBiosolidsSide-products |
| spellingShingle | Lajeunesse André Blais Mireille Barbeau Benoît Sauvé Sébastien Gagnon Christian Ozone oxidation of antidepressants in wastewater –Treatment evaluation and characterization of new by-products by LC-QToFMS Chemistry Central Journal Antidepressants Ozone LC-MS/MS Sewage treatment plants Biosolids Side-products |
| title | Ozone oxidation of antidepressants in wastewater –Treatment evaluation and characterization of new by-products by LC-QToFMS |
| title_full | Ozone oxidation of antidepressants in wastewater –Treatment evaluation and characterization of new by-products by LC-QToFMS |
| title_fullStr | Ozone oxidation of antidepressants in wastewater –Treatment evaluation and characterization of new by-products by LC-QToFMS |
| title_full_unstemmed | Ozone oxidation of antidepressants in wastewater –Treatment evaluation and characterization of new by-products by LC-QToFMS |
| title_short | Ozone oxidation of antidepressants in wastewater –Treatment evaluation and characterization of new by-products by LC-QToFMS |
| title_sort | ozone oxidation of antidepressants in wastewater treatment evaluation and characterization of new by products by lc qtofms |
| topic | Antidepressants Ozone LC-MS/MS Sewage treatment plants Biosolids Side-products |
| url | http://journal.chemistrycentral.com/content/7/1/15 |
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