Aberrant accumulation of NIK promotes tumor growth by dysregulating translation and post-translational modifications in breast cancer

Aberrant accumulation of NIK promotes tumor growth by dysregulating translation and post-translational modifications in breast cancer

Abstract Background In vivo investigations with cancer cells have powerful tools to discover cancer progression mechanisms and preclinical candidate drugs. Among these in vivo experimental models, the establishment of highly malignancy cell lines with xenograft has been frequently used. However, few...

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Bibliographic Details
Main Authors: Yusuke Hayashi, Jun Nakayama, Mizuki Yamamoto, Masashi Maekawa, Shinya Watanabe, Shigeki Higashiyama, Jun-ichiro Inoue, Yusuke Yamamoto, Kentaro Semba
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Cancer Cell International
Subjects:
NIK
Non-canonical NF-κB
Translation
Post-translational regulation
In vivo selection
Orthotopic xenograft
Online Access:https://doi.org/10.1186/s12935-023-02904-y

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