Central dogma rates and the trade-off between precision and economy in gene expression
The same protein abundance can be achieved by many combinations of transcription, translation and degradation rates. Here, the authors find that genes combining high transcription with low translation rate are rare due to a trade-off between the cost of transcription and expression noise.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07391-8 |
| _version_ | 1818433209924321280 |
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| author | Jean Hausser Avi Mayo Leeat Keren Uri Alon |
| author_facet | Jean Hausser Avi Mayo Leeat Keren Uri Alon |
| author_sort | Jean Hausser |
| collection | DOAJ |
| description | The same protein abundance can be achieved by many combinations of transcription, translation and degradation rates. Here, the authors find that genes combining high transcription with low translation rate are rare due to a trade-off between the cost of transcription and expression noise. |
| first_indexed | 2024-12-14T16:17:28Z |
| format | Article |
| id | doaj.art-49c76385217d4abdbed2391068e344b2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T16:17:28Z |
| publishDate | 2019-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-49c76385217d4abdbed2391068e344b22022-12-21T22:54:53ZengNature PortfolioNature Communications2041-17232019-01-0110111510.1038/s41467-018-07391-8Central dogma rates and the trade-off between precision and economy in gene expressionJean Hausser0Avi Mayo1Leeat Keren2Uri Alon3Department of Molecular Cell Biology, Weizmann Institute of ScienceDepartment of Molecular Cell Biology, Weizmann Institute of ScienceDepartment of Molecular Cell Biology, Weizmann Institute of ScienceDepartment of Molecular Cell Biology, Weizmann Institute of ScienceThe same protein abundance can be achieved by many combinations of transcription, translation and degradation rates. Here, the authors find that genes combining high transcription with low translation rate are rare due to a trade-off between the cost of transcription and expression noise.https://doi.org/10.1038/s41467-018-07391-8 |
| spellingShingle | Jean Hausser Avi Mayo Leeat Keren Uri Alon Central dogma rates and the trade-off between precision and economy in gene expression Nature Communications |
| title | Central dogma rates and the trade-off between precision and economy in gene expression |
| title_full | Central dogma rates and the trade-off between precision and economy in gene expression |
| title_fullStr | Central dogma rates and the trade-off between precision and economy in gene expression |
| title_full_unstemmed | Central dogma rates and the trade-off between precision and economy in gene expression |
| title_short | Central dogma rates and the trade-off between precision and economy in gene expression |
| title_sort | central dogma rates and the trade off between precision and economy in gene expression |
| url | https://doi.org/10.1038/s41467-018-07391-8 |
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