Genotype I African swine fever viruses emerged in domestic pigs in China and caused chronic infection
The Georgia-07-like genotype II African swine fever virus (ASFV) with high virulence has been prevalent in China since 2018. Here, we report that genotype I ASFVs have now also emerged in China. Two non-haemadsorbing genotype I ASFVs, HeN/ZZ-P1/21 and SD/DY-I/21, were isolated from pig farms in Hena...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2021.1999779 |
| _version_ | 1828751598448279552 |
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| author | Encheng Sun Lianyu Huang Xianfeng Zhang Jiwen Zhang Dongdong Shen Zhenjiang Zhang Zilong Wang Hong Huo Wenqing Wang Haoyue Huangfu Wan Wang Fang Li Renqiang Liu Jianhong Sun Zhijun Tian Wei Xia Yuntao Guan Xijun He Yuanmao Zhu Dongming Zhao Zhigao Bu |
| author_facet | Encheng Sun Lianyu Huang Xianfeng Zhang Jiwen Zhang Dongdong Shen Zhenjiang Zhang Zilong Wang Hong Huo Wenqing Wang Haoyue Huangfu Wan Wang Fang Li Renqiang Liu Jianhong Sun Zhijun Tian Wei Xia Yuntao Guan Xijun He Yuanmao Zhu Dongming Zhao Zhigao Bu |
| author_sort | Encheng Sun |
| collection | DOAJ |
| description | The Georgia-07-like genotype II African swine fever virus (ASFV) with high virulence has been prevalent in China since 2018. Here, we report that genotype I ASFVs have now also emerged in China. Two non-haemadsorbing genotype I ASFVs, HeN/ZZ-P1/21 and SD/DY-I/21, were isolated from pig farms in Henan and Shandong province, respectively. Phylogenetic analysis of the whole genome sequences suggested that both isolates share high similarity with NH/P68 and OURT88/3, two genotype I ASFVs isolated in Portugal in the last century. Animal challenge testing revealed that SD/DY-I/21 shows low virulence and efficient transmissibility in pigs, and causes mild onset of infection and chronic disease. SD/DY-I/21 was found to cause necrotic skin lesions and joint swelling. The emergence of genotype I ASFVs will present more problems and challenges for the control and prevention of African swine fever in China. |
| first_indexed | 2024-12-10T20:55:46Z |
| format | Article |
| id | doaj.art-49c8867d77d642cf91b385583192feb5 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-12-10T20:55:46Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-49c8867d77d642cf91b385583192feb52022-12-22T01:33:58ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512021-01-011012183219310.1080/22221751.2021.1999779Genotype I African swine fever viruses emerged in domestic pigs in China and caused chronic infectionEncheng Sun0Lianyu Huang1Xianfeng Zhang2Jiwen Zhang3Dongdong Shen4Zhenjiang Zhang5Zilong Wang6Hong Huo7Wenqing Wang8Haoyue Huangfu9Wan Wang10Fang Li11Renqiang Liu12Jianhong Sun13Zhijun Tian14Wei Xia15Yuntao Guan16Xijun He17Yuanmao Zhu18Dongming Zhao19Zhigao Bu20State Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaState Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of ChinaThe Georgia-07-like genotype II African swine fever virus (ASFV) with high virulence has been prevalent in China since 2018. Here, we report that genotype I ASFVs have now also emerged in China. Two non-haemadsorbing genotype I ASFVs, HeN/ZZ-P1/21 and SD/DY-I/21, were isolated from pig farms in Henan and Shandong province, respectively. Phylogenetic analysis of the whole genome sequences suggested that both isolates share high similarity with NH/P68 and OURT88/3, two genotype I ASFVs isolated in Portugal in the last century. Animal challenge testing revealed that SD/DY-I/21 shows low virulence and efficient transmissibility in pigs, and causes mild onset of infection and chronic disease. SD/DY-I/21 was found to cause necrotic skin lesions and joint swelling. The emergence of genotype I ASFVs will present more problems and challenges for the control and prevention of African swine fever in China.https://www.tandfonline.com/doi/10.1080/22221751.2021.1999779African swine fever virusgenotype IvirulencepigChina |
| spellingShingle | Encheng Sun Lianyu Huang Xianfeng Zhang Jiwen Zhang Dongdong Shen Zhenjiang Zhang Zilong Wang Hong Huo Wenqing Wang Haoyue Huangfu Wan Wang Fang Li Renqiang Liu Jianhong Sun Zhijun Tian Wei Xia Yuntao Guan Xijun He Yuanmao Zhu Dongming Zhao Zhigao Bu Genotype I African swine fever viruses emerged in domestic pigs in China and caused chronic infection Emerging Microbes and Infections African swine fever virus genotype I virulence pig China |
| title | Genotype I African swine fever viruses emerged in domestic pigs in China and caused chronic infection |
| title_full | Genotype I African swine fever viruses emerged in domestic pigs in China and caused chronic infection |
| title_fullStr | Genotype I African swine fever viruses emerged in domestic pigs in China and caused chronic infection |
| title_full_unstemmed | Genotype I African swine fever viruses emerged in domestic pigs in China and caused chronic infection |
| title_short | Genotype I African swine fever viruses emerged in domestic pigs in China and caused chronic infection |
| title_sort | genotype i african swine fever viruses emerged in domestic pigs in china and caused chronic infection |
| topic | African swine fever virus genotype I virulence pig China |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2021.1999779 |
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