Photoinactivation and Photoablation of <i>Porphyromonas gingivalis</i>
Several types of phototherapy target human pathogens and <i>Porphyromonas gingivitis</i> (<i>Pg</i>) in particular. The various approaches can be organized into five different treatment modes sorted by different power densities, interaction times, effective wavelengths and me...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/12/9/1160 |
| Summary: | Several types of phototherapy target human pathogens and <i>Porphyromonas gingivitis</i> (<i>Pg</i>) in particular. The various approaches can be organized into five different treatment modes sorted by different power densities, interaction times, effective wavelengths and mechanisms of action. Mode 1: antimicrobial ultraviolet (aUV); mode 2: antimicrobial blue light (aBL); mode 3: antimicrobial selective photothermolysis (aSP); mode 4: antimicrobial vaporization; mode 5: antimicrobial photodynamic therapy (aPDT). This report reviews the literature to identify for each mode (a) the putative molecular mechanism of action; (b) the effective wavelength range and penetration depth; (c) selectivity; (d) in vitro outcomes; and (e) clinical trial/study outcomes as these elements apply to <i>Porphyromonas gingivalis</i> (<i>Pg</i>). The characteristics of each mode influence how each is translated into the clinic. |
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| ISSN: | 2076-0817 |