Combined regional T1w/T2w ratio and voxel-based morphometry in multiple system atrophy: A follow-up study
Several MRI techniques have become available to support the early diagnosis of multiple system atrophy (MSA), but few longitudinal studies on both MSA variants have been performed, and there are no established MRI markers of disease progression. We aimed to characterize longitudinal brain changes in...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.1017311/full |
| _version_ | 1811237204044808192 |
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| author | Sara Ponticorvo Renzo Manara Maria Claudia Russillo Valentina Andreozzi Lorenzo Forino Roberto Erro Marina Picillo Marianna Amboni Sofia Cuoco Gianfranco Di Salle Francesco Di Salle Paolo Barone Fabrizio Esposito Maria Teresa Pellecchia |
| author_facet | Sara Ponticorvo Renzo Manara Maria Claudia Russillo Valentina Andreozzi Lorenzo Forino Roberto Erro Marina Picillo Marianna Amboni Sofia Cuoco Gianfranco Di Salle Francesco Di Salle Paolo Barone Fabrizio Esposito Maria Teresa Pellecchia |
| author_sort | Sara Ponticorvo |
| collection | DOAJ |
| description | Several MRI techniques have become available to support the early diagnosis of multiple system atrophy (MSA), but few longitudinal studies on both MSA variants have been performed, and there are no established MRI markers of disease progression. We aimed to characterize longitudinal brain changes in 26 patients with MSA (14 MSA-P and 12 MSA-C) over a 1-year follow-up period in terms of local tissue density and T1w/T2w ratio in a-priori regions, namely, bilateral putamen, cerebellar gray matter (GM), white matter (WM), and substantia nigra (SN). A significant GM density decrease was found in cerebellum and left putamen in the entire group (10.7 and 33.1% variation, respectively) and both MSA subtypes (MSA-C: 15.4 and 33.0% variation; MSA-P: 7.7 and 33.2%) and in right putamen in the entire group (19.8% variation) and patients with MSA-C (20.9% variation). A WM density decrease was found in the entire group (9.3% variation) and both subtypes in cerebellum-brainstem (MSA-C: 18.0% variation; MSA-P: 5% variation). The T1w/T2w ratio increase was found in the cerebellar and left putamen GM (6.6 and 24.9% variation), while a significant T1w/T2w ratio decrease was detected in SN in the entire MSA group (31% variation). We found a more progressive atrophy of the cerebellum in MSA-C with a similar progression of putaminal atrophy in the two variants. T1w/T2w ratio can be further studied as a potential marker of disease progression, possibly reflecting decreased neuronal density or iron accumulation. |
| first_indexed | 2024-04-12T12:22:00Z |
| format | Article |
| id | doaj.art-49d293ef47e347b0afeddba6146f7d43 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T12:22:00Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-49d293ef47e347b0afeddba6146f7d432022-12-22T03:33:17ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-10-011310.3389/fneur.2022.10173111017311Combined regional T1w/T2w ratio and voxel-based morphometry in multiple system atrophy: A follow-up studySara Ponticorvo0Renzo Manara1Maria Claudia Russillo2Valentina Andreozzi3Lorenzo Forino4Roberto Erro5Marina Picillo6Marianna Amboni7Sofia Cuoco8Gianfranco Di Salle9Francesco Di Salle10Paolo Barone11Fabrizio Esposito12Maria Teresa Pellecchia13Neuroscience Section, Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, ItalyNeuroradiology Unit, Department of Neurosciences, University of Padua, Padua, ItalyNeuroscience Section, Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, ItalyNeuroscience Section, Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, ItalyNeuroscience Section, Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, ItalyNeuroscience Section, Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, ItalyNeuroscience Section, Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, ItalyNeuroscience Section, Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, ItalyNeuroscience Section, Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, ItalyInstitute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, ItalyNeuroscience Section, Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, ItalyNeuroscience Section, Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples, ItalyNeuroscience Section, Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, ItalySeveral MRI techniques have become available to support the early diagnosis of multiple system atrophy (MSA), but few longitudinal studies on both MSA variants have been performed, and there are no established MRI markers of disease progression. We aimed to characterize longitudinal brain changes in 26 patients with MSA (14 MSA-P and 12 MSA-C) over a 1-year follow-up period in terms of local tissue density and T1w/T2w ratio in a-priori regions, namely, bilateral putamen, cerebellar gray matter (GM), white matter (WM), and substantia nigra (SN). A significant GM density decrease was found in cerebellum and left putamen in the entire group (10.7 and 33.1% variation, respectively) and both MSA subtypes (MSA-C: 15.4 and 33.0% variation; MSA-P: 7.7 and 33.2%) and in right putamen in the entire group (19.8% variation) and patients with MSA-C (20.9% variation). A WM density decrease was found in the entire group (9.3% variation) and both subtypes in cerebellum-brainstem (MSA-C: 18.0% variation; MSA-P: 5% variation). The T1w/T2w ratio increase was found in the cerebellar and left putamen GM (6.6 and 24.9% variation), while a significant T1w/T2w ratio decrease was detected in SN in the entire MSA group (31% variation). We found a more progressive atrophy of the cerebellum in MSA-C with a similar progression of putaminal atrophy in the two variants. T1w/T2w ratio can be further studied as a potential marker of disease progression, possibly reflecting decreased neuronal density or iron accumulation.https://www.frontiersin.org/articles/10.3389/fneur.2022.1017311/fullmultiple system atrophydisease progressionT1w/T2w ratioMRI markersneurodegeneration |
| spellingShingle | Sara Ponticorvo Renzo Manara Maria Claudia Russillo Valentina Andreozzi Lorenzo Forino Roberto Erro Marina Picillo Marianna Amboni Sofia Cuoco Gianfranco Di Salle Francesco Di Salle Paolo Barone Fabrizio Esposito Maria Teresa Pellecchia Combined regional T1w/T2w ratio and voxel-based morphometry in multiple system atrophy: A follow-up study Frontiers in Neurology multiple system atrophy disease progression T1w/T2w ratio MRI markers neurodegeneration |
| title | Combined regional T1w/T2w ratio and voxel-based morphometry in multiple system atrophy: A follow-up study |
| title_full | Combined regional T1w/T2w ratio and voxel-based morphometry in multiple system atrophy: A follow-up study |
| title_fullStr | Combined regional T1w/T2w ratio and voxel-based morphometry in multiple system atrophy: A follow-up study |
| title_full_unstemmed | Combined regional T1w/T2w ratio and voxel-based morphometry in multiple system atrophy: A follow-up study |
| title_short | Combined regional T1w/T2w ratio and voxel-based morphometry in multiple system atrophy: A follow-up study |
| title_sort | combined regional t1w t2w ratio and voxel based morphometry in multiple system atrophy a follow up study |
| topic | multiple system atrophy disease progression T1w/T2w ratio MRI markers neurodegeneration |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.1017311/full |
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