Design, Synthesis, and Biological Evaluation of Novel Dihydropyridine and Pyridine Analogs as Potent Human Tissue Nonspecific Alkaline Phosphatase Inhibitors with Anticancer Activity: ROS and DNA Damage-Induced Apoptosis

Design, Synthesis, and Biological Evaluation of Novel Dihydropyridine and Pyridine Analogs as Potent Human Tissue Nonspecific Alkaline Phosphatase Inhibitors with Anticancer Activity: ROS and DNA Damage-Induced Apoptosis

Small molecules with nitrogen-containing scaffolds have gained much attention due to their biological importance in the development of new anticancer agents. The present paper reports the synthesis of a library of new dihydropyridine and pyridine analogs with diverse pharmacophores. All compounds we...

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Bibliographic Details
Main Authors: Nazeer Ahmad Khan, Faisal Rashid, Muhammad Siraj Khan Jadoon, Saquib Jalil, Zulfiqar Ali Khan, Raha Orfali, Shagufta Perveen, Areej Al-Taweel, Jamshed Iqbal, Sohail Anjum Shahzad
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
dihydropyridines
pyridines
anticancer activity
apoptosis (flow cytometry
ROS
PI and DAPI)
Online Access:https://www.mdpi.com/1420-3049/27/19/6235

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