Lipiodol nanoemulsions stabilized with polyglycerol-polycaprolactone block copolymers for theranostic applications
Abstract Background Polyglycerol is an attractive hydrophilic building block of amphiphilic copolymers for biomedical and pharmaceutical applications due to its biocompatibility, facile chemical modification, and anti-fouling activity. Herein we introduce theranostic nanoemulsions incorporating anti...
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2017-10-01
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| Series: | Biomaterials Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40824-017-0108-4 |
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| author | Trang Huyen Le Kim Hwiseok Jun Jin Ho Kim Keunchil Park Jee Seon Kim Yoon Sung Nam |
| author_facet | Trang Huyen Le Kim Hwiseok Jun Jin Ho Kim Keunchil Park Jee Seon Kim Yoon Sung Nam |
| author_sort | Trang Huyen Le Kim |
| collection | DOAJ |
| description | Abstract Background Polyglycerol is an attractive hydrophilic building block of amphiphilic copolymers for biomedical and pharmaceutical applications due to its biocompatibility, facile chemical modification, and anti-fouling activity. Herein we introduce theranostic nanoemulsions incorporating anti-cancer therapeutic and contrast agents using linear polyglycerol-poly(ε-caprolactone) diblock copolymers (PG-b-PCL). Lipiodol is used as a core oil that dissolves paclitaxel and serves as a contrast agent for computer tomography (CT). Methods PG-b-PCL is synthesized by three-step processes: polymerization of ethoxyethyl glycerol ether; ring-opening polymerization of ε-caprolactone; and deprotection of the PEEGE block. In vitro cytotoxicity of the polyglycerolated lipiodol nanoemulsions is demonstrated using HeLa ovarian cancer cells. The applicability of the prepared nanoemulsions as a contrast agent for CT imaging is also evaluated using micro-CT. Results Three compositions of PG-b-PCL with different block lengths are synthesized to prepare nanoemulsions. The polyglycerolated lipiodol nanoemulsions exhibit excellent anti-cancer activities, while placebo nanoemulsions have no significant cytotoxicity under the same condition. Micro-CT imaging of the nanoemulsions confirms the ability of nanoemulsions as a contrast agent. Conclusions This study suggests that PG-b-PCL is a promising polymeric emulsifier for effective stabilization and surface functionalization of drug delivery nanocarriers for therapeutic and imaging agents. |
| first_indexed | 2024-03-07T17:18:00Z |
| format | Article |
| id | doaj.art-49d397dba9b04460a9a384067811d90e |
| institution | Directory Open Access Journal |
| issn | 2055-7124 |
| language | English |
| last_indexed | 2024-03-07T17:18:00Z |
| publishDate | 2017-10-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Biomaterials Research |
| spelling | doaj.art-49d397dba9b04460a9a384067811d90e2024-03-02T21:45:15ZengAmerican Association for the Advancement of Science (AAAS)Biomaterials Research2055-71242017-10-0121111010.1186/s40824-017-0108-4Lipiodol nanoemulsions stabilized with polyglycerol-polycaprolactone block copolymers for theranostic applicationsTrang Huyen Le Kim0Hwiseok Jun1Jin Ho Kim2Keunchil Park3Jee Seon Kim4Yoon Sung Nam5Department of Materials Science and Engineering, Korea Advanced Institute of Science and TechnologyDepartment of Materials Science and Engineering, Korea Advanced Institute of Science and TechnologySamsung Medical Center, Samsung Biomedical Research InstituteSamsung Biomedical Research Institute and Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Materials Science and Engineering, Korea Advanced Institute of Science and TechnologyDepartment of Materials Science and Engineering and KAIST Institute for the NanoCentury, Korea Advanced Institute of Science and TechnologyAbstract Background Polyglycerol is an attractive hydrophilic building block of amphiphilic copolymers for biomedical and pharmaceutical applications due to its biocompatibility, facile chemical modification, and anti-fouling activity. Herein we introduce theranostic nanoemulsions incorporating anti-cancer therapeutic and contrast agents using linear polyglycerol-poly(ε-caprolactone) diblock copolymers (PG-b-PCL). Lipiodol is used as a core oil that dissolves paclitaxel and serves as a contrast agent for computer tomography (CT). Methods PG-b-PCL is synthesized by three-step processes: polymerization of ethoxyethyl glycerol ether; ring-opening polymerization of ε-caprolactone; and deprotection of the PEEGE block. In vitro cytotoxicity of the polyglycerolated lipiodol nanoemulsions is demonstrated using HeLa ovarian cancer cells. The applicability of the prepared nanoemulsions as a contrast agent for CT imaging is also evaluated using micro-CT. Results Three compositions of PG-b-PCL with different block lengths are synthesized to prepare nanoemulsions. The polyglycerolated lipiodol nanoemulsions exhibit excellent anti-cancer activities, while placebo nanoemulsions have no significant cytotoxicity under the same condition. Micro-CT imaging of the nanoemulsions confirms the ability of nanoemulsions as a contrast agent. Conclusions This study suggests that PG-b-PCL is a promising polymeric emulsifier for effective stabilization and surface functionalization of drug delivery nanocarriers for therapeutic and imaging agents.http://link.springer.com/article/10.1186/s40824-017-0108-4PolyglycerolAmphiphilic copolymersNanoemulsionsLipiodolPaclitaxelCancer |
| spellingShingle | Trang Huyen Le Kim Hwiseok Jun Jin Ho Kim Keunchil Park Jee Seon Kim Yoon Sung Nam Lipiodol nanoemulsions stabilized with polyglycerol-polycaprolactone block copolymers for theranostic applications Biomaterials Research Polyglycerol Amphiphilic copolymers Nanoemulsions Lipiodol Paclitaxel Cancer |
| title | Lipiodol nanoemulsions stabilized with polyglycerol-polycaprolactone block copolymers for theranostic applications |
| title_full | Lipiodol nanoemulsions stabilized with polyglycerol-polycaprolactone block copolymers for theranostic applications |
| title_fullStr | Lipiodol nanoemulsions stabilized with polyglycerol-polycaprolactone block copolymers for theranostic applications |
| title_full_unstemmed | Lipiodol nanoemulsions stabilized with polyglycerol-polycaprolactone block copolymers for theranostic applications |
| title_short | Lipiodol nanoemulsions stabilized with polyglycerol-polycaprolactone block copolymers for theranostic applications |
| title_sort | lipiodol nanoemulsions stabilized with polyglycerol polycaprolactone block copolymers for theranostic applications |
| topic | Polyglycerol Amphiphilic copolymers Nanoemulsions Lipiodol Paclitaxel Cancer |
| url | http://link.springer.com/article/10.1186/s40824-017-0108-4 |
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