Evaluation of Uterine Artery Doppler and Estrogen Milieu in Oocyte Donation Pregnancies—A Pilot Study
Oocyte donations (OD) represent 4.5% of all in vitro fertilization (IVF) cycles. While OD pregnancies face increased risks of obstetrical complications, especially pregnancy-induced hypertension and pre-eclampsia (PE), little is known about the physiology and the physiopathology of placentation. We...
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MDPI AG
2020-04-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/5/254 |
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| author | Luca Mandia Paolo Cavoretto Piergiorgio Duca Massimo Candiani Irene Cetin Valeria Savasi |
| author_facet | Luca Mandia Paolo Cavoretto Piergiorgio Duca Massimo Candiani Irene Cetin Valeria Savasi |
| author_sort | Luca Mandia |
| collection | DOAJ |
| description | Oocyte donations (OD) represent 4.5% of all in vitro fertilization (IVF) cycles. While OD pregnancies face increased risks of obstetrical complications, especially pregnancy-induced hypertension and pre-eclampsia (PE), little is known about the physiology and the physiopathology of placentation. We performed a prospective case-control study to analyze uterine artery Doppler pulsatility index (UtA-PI) and serum maternal 17β-estradiol (17β-E) at 11 + 0 to 13 + 6 weeks’ gestation in singleton pregnancies with different modes of conception. Study groups were: 55 OD, 48 IVF with autologous oocytes from fresh cycles (Autologous-Fresh IVF), 10 IVF with autologous oocytes from frozen cycles (Autologous-Frozen IVF) and 122 spontaneously conceived pregnancies (SC). The mean UtA-PI and serum maternal 17β-E at 11 to 13 + 6 weeks were significantly lower in OD as compared to SC and autologous IVF, either from fresh or frozen cycles. Oocyte donation presents lower UtA-PI and lower serum 17β-E in the first trimester of pregnancy. The etiology of these particularr differences is likely multifactorial and deserves further investigation. |
| first_indexed | 2024-03-10T20:13:07Z |
| format | Article |
| id | doaj.art-49d760ce68ae47d3b7bf11d0ea6002e8 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T20:13:07Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-49d760ce68ae47d3b7bf11d0ea6002e82023-11-19T22:46:23ZengMDPI AGDiagnostics2075-44182020-04-0110525410.3390/diagnostics10050254Evaluation of Uterine Artery Doppler and Estrogen Milieu in Oocyte Donation Pregnancies—A Pilot StudyLuca Mandia0Paolo Cavoretto1Piergiorgio Duca2Massimo Candiani3Irene Cetin4Valeria Savasi5Unit of Obstetrics and Gynecology, Department of Biomedical and Clinical Sciences, ASST Fatebenefratelli Sacco, University of Milan, Via G. B. Grassi, 74, 20157 Milan, ItalyDepartment of Obstetrics and Gynecology, IRCCS Ospedale San Raffaele, University Vita-Salute San Raffaele, 20132 Milan, ItalyStatistical and Biometry Unit, Department of Biomedical and Clinical Sciences, University of Milan, Via G. B. Grassi, 74, 20157 Milan, ItalyDepartment of Obstetrics and Gynecology, IRCCS Ospedale San Raffaele, University Vita-Salute San Raffaele, 20132 Milan, ItalyUnit of Obstetrics and Gynecology, Department of Biomedical and Clinical Sciences, ASST Fatebenefratelli Sacco, University of Milan, Via G. B. Grassi, 74, 20157 Milan, ItalyUnit of Obstetrics and Gynecology, Department of Biomedical and Clinical Sciences, ASST Fatebenefratelli Sacco, University of Milan, Via G. B. Grassi, 74, 20157 Milan, ItalyOocyte donations (OD) represent 4.5% of all in vitro fertilization (IVF) cycles. While OD pregnancies face increased risks of obstetrical complications, especially pregnancy-induced hypertension and pre-eclampsia (PE), little is known about the physiology and the physiopathology of placentation. We performed a prospective case-control study to analyze uterine artery Doppler pulsatility index (UtA-PI) and serum maternal 17β-estradiol (17β-E) at 11 + 0 to 13 + 6 weeks’ gestation in singleton pregnancies with different modes of conception. Study groups were: 55 OD, 48 IVF with autologous oocytes from fresh cycles (Autologous-Fresh IVF), 10 IVF with autologous oocytes from frozen cycles (Autologous-Frozen IVF) and 122 spontaneously conceived pregnancies (SC). The mean UtA-PI and serum maternal 17β-E at 11 to 13 + 6 weeks were significantly lower in OD as compared to SC and autologous IVF, either from fresh or frozen cycles. Oocyte donation presents lower UtA-PI and lower serum 17β-E in the first trimester of pregnancy. The etiology of these particularr differences is likely multifactorial and deserves further investigation.https://www.mdpi.com/2075-4418/10/5/254IVFoocyte donationuterine arteries Dopplerestrogen milieufirst trimester |
| spellingShingle | Luca Mandia Paolo Cavoretto Piergiorgio Duca Massimo Candiani Irene Cetin Valeria Savasi Evaluation of Uterine Artery Doppler and Estrogen Milieu in Oocyte Donation Pregnancies—A Pilot Study Diagnostics IVF oocyte donation uterine arteries Doppler estrogen milieu first trimester |
| title | Evaluation of Uterine Artery Doppler and Estrogen Milieu in Oocyte Donation Pregnancies—A Pilot Study |
| title_full | Evaluation of Uterine Artery Doppler and Estrogen Milieu in Oocyte Donation Pregnancies—A Pilot Study |
| title_fullStr | Evaluation of Uterine Artery Doppler and Estrogen Milieu in Oocyte Donation Pregnancies—A Pilot Study |
| title_full_unstemmed | Evaluation of Uterine Artery Doppler and Estrogen Milieu in Oocyte Donation Pregnancies—A Pilot Study |
| title_short | Evaluation of Uterine Artery Doppler and Estrogen Milieu in Oocyte Donation Pregnancies—A Pilot Study |
| title_sort | evaluation of uterine artery doppler and estrogen milieu in oocyte donation pregnancies a pilot study |
| topic | IVF oocyte donation uterine arteries Doppler estrogen milieu first trimester |
| url | https://www.mdpi.com/2075-4418/10/5/254 |
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