Bacterial Isolates and Resistance Patterns in Preterm Infants with Sepsis in Selected Hospitals in Ethiopia: A Longitudinal Observational Study
Background: Neonatal sepsis is the third leading cause of neonatal mortality, behind prematurity and intrapartum-related complications. The main objectives of this study are to assess the proportion of sepsis in preterm newborns and identify the etiologic agents and their antibiotic sensitivity patt...
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Format: | Article |
Language: | English |
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SAGE Publishing
2020-10-01
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Series: | Global Pediatric Health |
Online Access: | https://doi.org/10.1177/2333794X20953318 |
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author | Beza Eshetu MD Mulatu Gashaw MSc Semaria Solomon MSc Melkamu Berhane MD Kassie Molla BSc Tamrat Abebe PhD Solomon Gizaw MSc Alemseged Abdissa PhD Mahlet Abayneh MD Robert L. Goldenberg MD, PhD Zemene Tigabu MD Amha Mekasha MD Bogale Worku MD Elizabeth M. McClure PhD Assaye K. Nigusse MD Lulu M. Muhe MD, PhD |
author_facet | Beza Eshetu MD Mulatu Gashaw MSc Semaria Solomon MSc Melkamu Berhane MD Kassie Molla BSc Tamrat Abebe PhD Solomon Gizaw MSc Alemseged Abdissa PhD Mahlet Abayneh MD Robert L. Goldenberg MD, PhD Zemene Tigabu MD Amha Mekasha MD Bogale Worku MD Elizabeth M. McClure PhD Assaye K. Nigusse MD Lulu M. Muhe MD, PhD |
author_sort | Beza Eshetu MD |
collection | DOAJ |
description | Background: Neonatal sepsis is the third leading cause of neonatal mortality, behind prematurity and intrapartum-related complications. The main objectives of this study are to assess the proportion of sepsis in preterm newborns and identify the etiologic agents and their antibiotic sensitivity patterns. Methods: A longitudinal observational study was done from July 2016 to May 2018. Whenever clinical diagnosis of sepsis was made, blood cultures and antibiotic susceptibility tests were done. Result: We did 690 blood cultures, 255 (36.9%) showing bacterial growth. The most commonly isolated bacteria were Klebsiella species 78 (36.6%), Coagulase negative Staphylococcus 42 (19.7%) and Staphylococcus aureus 39 (18.3%). Gram-positive bacteria showed high resistance to penicillin (98.9%) and ceftriaxone (91.3%) whereas Gram-negative bacteria were highly resistant to gentamicin (83.2%) and ceftriaxone (83.2%). Conclusion: Resistance to the more commonly used antibiotics such as ampicillin and gentamycin was very high, necessitating reconsideration of the empiric use of these antibiotics. |
first_indexed | 2024-04-12T21:57:18Z |
format | Article |
id | doaj.art-49d77dc0507c43279647cced380d2f8a |
institution | Directory Open Access Journal |
issn | 2333-794X |
language | English |
last_indexed | 2024-04-12T21:57:18Z |
publishDate | 2020-10-01 |
publisher | SAGE Publishing |
record_format | Article |
series | Global Pediatric Health |
spelling | doaj.art-49d77dc0507c43279647cced380d2f8a2022-12-22T03:15:16ZengSAGE PublishingGlobal Pediatric Health2333-794X2020-10-01710.1177/2333794X20953318Bacterial Isolates and Resistance Patterns in Preterm Infants with Sepsis in Selected Hospitals in Ethiopia: A Longitudinal Observational StudyBeza Eshetu MD0Mulatu Gashaw MSc1Semaria Solomon MSc2Melkamu Berhane MD3Kassie Molla BSc4Tamrat Abebe PhD5Solomon Gizaw MSc6Alemseged Abdissa PhD7Mahlet Abayneh MD8Robert L. Goldenberg MD, PhD9Zemene Tigabu MD10Amha Mekasha MD11Bogale Worku MD12Elizabeth M. McClure PhD13Assaye K. Nigusse MD14Lulu M. Muhe MD, PhD15Jimma University College of Public Health and Medical Sciences, Jimma, EthiopiaJimma University College of Public Health and Medical Sciences, Jimma, EthiopiaSt Paul Millennium Medical College Hospital, Addis Ababa, EthiopiaJimma University College of Public Health and Medical Sciences, Jimma, EthiopiaUniversity of Gondar, Gondar, EthiopiaAddis Ababa University College of Health Sciences, Addis Ababa, EthiopiaAddis Ababa University College of Health Sciences, Addis Ababa, EthiopiaJimma University College of Public Health and Medical Sciences, Jimma, EthiopiaSt Paul Millennium Medical College Hospital, Addis Ababa, EthiopiaColumbia University, NY, USAUniversity of Gondar, Gondar, EthiopiaAddis Ababa University College of Health Sciences, Addis Ababa, EthiopiaEthiopian Pediatric Society, Addis Ababa, EthiopiaRTI International, Research Triangle Park, USABill & Melinda Gates Foundation, Seattle, WA, USAAddis Ababa University College of Health Sciences, Addis Ababa, EthiopiaBackground: Neonatal sepsis is the third leading cause of neonatal mortality, behind prematurity and intrapartum-related complications. The main objectives of this study are to assess the proportion of sepsis in preterm newborns and identify the etiologic agents and their antibiotic sensitivity patterns. Methods: A longitudinal observational study was done from July 2016 to May 2018. Whenever clinical diagnosis of sepsis was made, blood cultures and antibiotic susceptibility tests were done. Result: We did 690 blood cultures, 255 (36.9%) showing bacterial growth. The most commonly isolated bacteria were Klebsiella species 78 (36.6%), Coagulase negative Staphylococcus 42 (19.7%) and Staphylococcus aureus 39 (18.3%). Gram-positive bacteria showed high resistance to penicillin (98.9%) and ceftriaxone (91.3%) whereas Gram-negative bacteria were highly resistant to gentamicin (83.2%) and ceftriaxone (83.2%). Conclusion: Resistance to the more commonly used antibiotics such as ampicillin and gentamycin was very high, necessitating reconsideration of the empiric use of these antibiotics.https://doi.org/10.1177/2333794X20953318 |
spellingShingle | Beza Eshetu MD Mulatu Gashaw MSc Semaria Solomon MSc Melkamu Berhane MD Kassie Molla BSc Tamrat Abebe PhD Solomon Gizaw MSc Alemseged Abdissa PhD Mahlet Abayneh MD Robert L. Goldenberg MD, PhD Zemene Tigabu MD Amha Mekasha MD Bogale Worku MD Elizabeth M. McClure PhD Assaye K. Nigusse MD Lulu M. Muhe MD, PhD Bacterial Isolates and Resistance Patterns in Preterm Infants with Sepsis in Selected Hospitals in Ethiopia: A Longitudinal Observational Study Global Pediatric Health |
title | Bacterial Isolates and Resistance Patterns in Preterm Infants with Sepsis in Selected Hospitals in Ethiopia: A Longitudinal Observational Study |
title_full | Bacterial Isolates and Resistance Patterns in Preterm Infants with Sepsis in Selected Hospitals in Ethiopia: A Longitudinal Observational Study |
title_fullStr | Bacterial Isolates and Resistance Patterns in Preterm Infants with Sepsis in Selected Hospitals in Ethiopia: A Longitudinal Observational Study |
title_full_unstemmed | Bacterial Isolates and Resistance Patterns in Preterm Infants with Sepsis in Selected Hospitals in Ethiopia: A Longitudinal Observational Study |
title_short | Bacterial Isolates and Resistance Patterns in Preterm Infants with Sepsis in Selected Hospitals in Ethiopia: A Longitudinal Observational Study |
title_sort | bacterial isolates and resistance patterns in preterm infants with sepsis in selected hospitals in ethiopia a longitudinal observational study |
url | https://doi.org/10.1177/2333794X20953318 |
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