Si-Ni-San alleviates early life stress-induced depression-like behaviors in adolescence via modulating Rac1 activity and associated spine plasticity in the nucleus accumbens

Si-Ni-San alleviates early life stress-induced depression-like behaviors in adolescence via modulating Rac1 activity and associated spine plasticity in the nucleus accumbens

Background: Early life stress (ELS) is a major risk factor for depression in adolescents. The nucleus accumbens (NAc) is a key center of the reward system, and spine remodeling in the NAc contributes to the development of depression. The Si-Ni-San formula (SNS) is a fundamental prescription for trea...

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Bibliographic Details
Main Authors: Lihong Ye, Jiayi Wu, Zuyi Liu, Di Deng, Shasha Bai, Lei Yang, Yao Xuan, Zehao Liu, Yafei Shi, Zhongqiu Liu, Rong Zhang, Jinlan Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pharmacology
Subjects:
early life stress
nucleus accumbens
adolescent depression
spine plasticity
Si-Ni-San
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1274121/full

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