Factors associated with short recurrence-free survival in completely resected colon cancer
Background: Several factors could affect disease recurrence in surgically resected colon cancer. While the role of certain factors such as cancer stage and grade is well established, the role of other factors (e.g., histological subtypes) is yet to be determined. Objective:Therefore, we conducted a...
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| Format: | Article |
| Language: | English |
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Greater Baltimore Medical Center
2017-11-01
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| Series: | Journal of Community Hospital Internal Medicine Perspectives |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/20009666.2017.1407210 |
| _version_ | 1797968054563373056 |
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| author | Yanal Alnimer Ranine Ghamrawi Ahmed Aburahma Samer Salah Carlos Rios-Bedoya Khalil Katato |
| author_facet | Yanal Alnimer Ranine Ghamrawi Ahmed Aburahma Samer Salah Carlos Rios-Bedoya Khalil Katato |
| author_sort | Yanal Alnimer |
| collection | DOAJ |
| description | Background: Several factors could affect disease recurrence in surgically resected colon cancer. While the role of certain factors such as cancer stage and grade is well established, the role of other factors (e.g., histological subtypes) is yet to be determined. Objective:Therefore, we conducted a study to evaluate the impact of several factors in recurrence-free survival (RFS) in patients who were disease free following surgical resection of the colon cancer. Design/Methods: Data were collected for patients with Stage I–III colon cancer who underwent complete surgical resection of the tumor between January 2010 and December 2015 in our institution. A total of 90 subjects met the inclusion criteria and were included in the study. The following factors were collected at the time of surgical resection of the colonic tumor: patient’s age, gender, colon cancer stage, grade and histological subtype, body mass index, hemoglobin A1c, and smoking history. Results: A total of 28 patients (31%) developed recurrence and had a mean follow-up time of 19.8 months (range: 2–54.4 months). Median RFS was 54.4 months with a 5-year RFS of 49%. Advanced colonic cancer stage and mucinous histological subtype were associated with shorter RFS with an HR of 2.37, 95% CI = 1.38–4.06, and 95% CI = 1.02–5.90, respectively. Current smokers or those who quit less than 15 years earlier tended to have worse RFS with an HR of 2.47, 95% CI = 0.98–6.27. Conclusion: Advanced colon cancer stage and mucinous histological subtype are independent risk factors for cancer recurrence and shorter RFS in completely resected colonic tumor. |
| first_indexed | 2024-04-11T02:39:52Z |
| format | Article |
| id | doaj.art-49dae33774e846a0bf0620c13dce2c80 |
| institution | Directory Open Access Journal |
| issn | 2000-9666 |
| language | English |
| last_indexed | 2024-04-11T02:39:52Z |
| publishDate | 2017-11-01 |
| publisher | Greater Baltimore Medical Center |
| record_format | Article |
| series | Journal of Community Hospital Internal Medicine Perspectives |
| spelling | doaj.art-49dae33774e846a0bf0620c13dce2c802023-01-02T19:11:50ZengGreater Baltimore Medical CenterJournal of Community Hospital Internal Medicine Perspectives2000-96662017-11-017634134610.1080/20009666.2017.14072101407210Factors associated with short recurrence-free survival in completely resected colon cancerYanal Alnimer0Ranine Ghamrawi1Ahmed Aburahma2Samer Salah3Carlos Rios-Bedoya4Khalil Katato5Michigan State UniversityMichigan State UniversityMichigan State UniversityKing Hussein Cancer CenterMichigan State UniversityMichigan State UniversityBackground: Several factors could affect disease recurrence in surgically resected colon cancer. While the role of certain factors such as cancer stage and grade is well established, the role of other factors (e.g., histological subtypes) is yet to be determined. Objective:Therefore, we conducted a study to evaluate the impact of several factors in recurrence-free survival (RFS) in patients who were disease free following surgical resection of the colon cancer. Design/Methods: Data were collected for patients with Stage I–III colon cancer who underwent complete surgical resection of the tumor between January 2010 and December 2015 in our institution. A total of 90 subjects met the inclusion criteria and were included in the study. The following factors were collected at the time of surgical resection of the colonic tumor: patient’s age, gender, colon cancer stage, grade and histological subtype, body mass index, hemoglobin A1c, and smoking history. Results: A total of 28 patients (31%) developed recurrence and had a mean follow-up time of 19.8 months (range: 2–54.4 months). Median RFS was 54.4 months with a 5-year RFS of 49%. Advanced colonic cancer stage and mucinous histological subtype were associated with shorter RFS with an HR of 2.37, 95% CI = 1.38–4.06, and 95% CI = 1.02–5.90, respectively. Current smokers or those who quit less than 15 years earlier tended to have worse RFS with an HR of 2.47, 95% CI = 0.98–6.27. Conclusion: Advanced colon cancer stage and mucinous histological subtype are independent risk factors for cancer recurrence and shorter RFS in completely resected colonic tumor.http://dx.doi.org/10.1080/20009666.2017.1407210Colon cancermucinous histologysmokingrecurrence-free survival |
| spellingShingle | Yanal Alnimer Ranine Ghamrawi Ahmed Aburahma Samer Salah Carlos Rios-Bedoya Khalil Katato Factors associated with short recurrence-free survival in completely resected colon cancer Journal of Community Hospital Internal Medicine Perspectives Colon cancer mucinous histology smoking recurrence-free survival |
| title | Factors associated with short recurrence-free survival in completely resected colon cancer |
| title_full | Factors associated with short recurrence-free survival in completely resected colon cancer |
| title_fullStr | Factors associated with short recurrence-free survival in completely resected colon cancer |
| title_full_unstemmed | Factors associated with short recurrence-free survival in completely resected colon cancer |
| title_short | Factors associated with short recurrence-free survival in completely resected colon cancer |
| title_sort | factors associated with short recurrence free survival in completely resected colon cancer |
| topic | Colon cancer mucinous histology smoking recurrence-free survival |
| url | http://dx.doi.org/10.1080/20009666.2017.1407210 |
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