Rational Design and Lead Optimisation of Potent Antimalarial Quinazolinediones and Their Cytotoxicity against MCF-7

Rational Design and Lead Optimisation of Potent Antimalarial Quinazolinediones and Their Cytotoxicity against MCF-7

Quinazolinedione is one of the most outstanding heterocycles in medicinal chemistry thanks to its wide ranges of biological activities including antimalarial, anticancer, and anti-inflammatory. TCMDC-125133 containing a quinazolinedione pharmacophore displays promising antimalarial activity and low...

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Bibliographic Details
Main Authors: Sitthivut Charoensutthivarakul, Duangporn Lohawittayanan, Phongthon Kanjanasirirat, Kedchin Jearawuttanakul, Sawinee Seemakhan, Napason Chabang, Patrick Schlaeppi, Varisa Tantivess, Tanapol Limboonreung, Matthew Phanchana
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Molecules
Subjects:
quinazolinedione derivatives
antimalarial activity
antiproliferative activity
Online Access:https://www.mdpi.com/1420-3049/28/7/2999

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