Micropulse Laser Trabeculoplasty with 577 nm Wavelength at 1500 or 1000 mW for Primary Open-Angle Glaucoma: A Pilot Study
<b>Aim</b>: To investigate the efficacy and safety of micropulse laser trabeculoplasty (MLT) using a 577 nm yellow wavelength laser randomly assigned to either 1500 or 1000 mW in patients with primary open-angle glaucoma (POAG). <b>Methods</b>: A prospective, double-blinded s...
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MDPI AG
2023-04-01
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| Online Access: | https://www.mdpi.com/2075-1729/13/4/982 |
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| author | Tommaso Verdina Matteo Gironi Bruno Battaglia Michele Gentile Johanna Chester Shaniko Kaleci Gianluca Scatigna Rodolfo Mastropasqua Gian Maria Cavallini |
| author_facet | Tommaso Verdina Matteo Gironi Bruno Battaglia Michele Gentile Johanna Chester Shaniko Kaleci Gianluca Scatigna Rodolfo Mastropasqua Gian Maria Cavallini |
| author_sort | Tommaso Verdina |
| collection | DOAJ |
| description | <b>Aim</b>: To investigate the efficacy and safety of micropulse laser trabeculoplasty (MLT) using a 577 nm yellow wavelength laser randomly assigned to either 1500 or 1000 mW in patients with primary open-angle glaucoma (POAG). <b>Methods</b>: A prospective, double-blinded study of POAG patients was performed in a single center. MLT treatment included a 577 nm micropulse laser (IRIDEX IQ 577<sup>TM</sup>, IRIDEX, Mountain View, CA, USA) to 360° of the trabecular meshwork at randomly assigned varying powers: 1500 mW in one eye (MLT 1500 group) and 1000 mW in the other (MLT 1000 group). Best-corrected visual acuity (BCVA), intraocular pressure (IOP), corneal central thickness (CCT), and endothelial cell count (ECC) were evaluated at baseline (T0), post-operative 1 h (T1), 24 h (T2), 1 month (T3), 3 months (T4), and 6 months (T5) after laser treatment. Topical medications were assessed pre-treatment and at T4. <b>Results</b>: Among the 18 eyes included, we achieved a success rate (IOP reduced > 20%) in 77% of sampled eyes. In particular, IOP reduced at T2 and T3 with both MLT 1500 and 1000 without any significant differences (IOP reduction 22.9% vs. 17.3%, respectively, MLT1500 vs. MLT1000 at T2). The IOP returned to baseline values at T4 and T5 in both groups, with a reduction in topical medications administered from 2.5 ± 1.1 to 2.0 ± 1.2 to the 1500 mW group and from 2.4 ± 1.0 to 1.9 ± 1.0 to the 1000 mW group. At 1 h post-laser treatment, a transient IOP spike was registered among the MLT1500 group. There were no differences in CCT and ECC at any timepoint according to the laser powers. <b>Conclusions</b>: Over a 6-month follow-up period, 577 nm MLT at either 1500 or 1000 mW reduces IOP, enabling a stable reduction in the number of topical medications required for patients treated for POAG without any significant difference in terms of effectiveness and safety. |
| first_indexed | 2024-03-11T04:49:53Z |
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| id | doaj.art-49dd1a5f3ca84958acae8f4593129f01 |
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| last_indexed | 2024-03-11T04:49:53Z |
| publishDate | 2023-04-01 |
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| spelling | doaj.art-49dd1a5f3ca84958acae8f4593129f012023-11-17T20:06:25ZengMDPI AGLife2075-17292023-04-0113498210.3390/life13040982Micropulse Laser Trabeculoplasty with 577 nm Wavelength at 1500 or 1000 mW for Primary Open-Angle Glaucoma: A Pilot StudyTommaso Verdina0Matteo Gironi1Bruno Battaglia2Michele Gentile3Johanna Chester4Shaniko Kaleci5Gianluca Scatigna6Rodolfo Mastropasqua7Gian Maria Cavallini8Ophthalmology Clinic, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, 41122 Modena, ItalyOphthalmology Clinic, Department of Medicine and Science of Ageing, University G. D’Annunzio Chieti-Pescara, 66100 Chieti, ItalyOphthalmology Clinic, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, 41122 Modena, ItalyOphthalmology Clinic, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, 41122 Modena, ItalyDepartment of Surgical, Medical, Dental and Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, 41121 Modena, ItalyDepartment of Surgical, Medical, Dental and Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, 41121 Modena, ItalyOphthalmology Clinic, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, 41122 Modena, ItalyOphthalmology Clinic, Department of Medicine and Science of Ageing, University G. D’Annunzio Chieti-Pescara, 66100 Chieti, ItalyOphthalmology Clinic, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, 41122 Modena, Italy<b>Aim</b>: To investigate the efficacy and safety of micropulse laser trabeculoplasty (MLT) using a 577 nm yellow wavelength laser randomly assigned to either 1500 or 1000 mW in patients with primary open-angle glaucoma (POAG). <b>Methods</b>: A prospective, double-blinded study of POAG patients was performed in a single center. MLT treatment included a 577 nm micropulse laser (IRIDEX IQ 577<sup>TM</sup>, IRIDEX, Mountain View, CA, USA) to 360° of the trabecular meshwork at randomly assigned varying powers: 1500 mW in one eye (MLT 1500 group) and 1000 mW in the other (MLT 1000 group). Best-corrected visual acuity (BCVA), intraocular pressure (IOP), corneal central thickness (CCT), and endothelial cell count (ECC) were evaluated at baseline (T0), post-operative 1 h (T1), 24 h (T2), 1 month (T3), 3 months (T4), and 6 months (T5) after laser treatment. Topical medications were assessed pre-treatment and at T4. <b>Results</b>: Among the 18 eyes included, we achieved a success rate (IOP reduced > 20%) in 77% of sampled eyes. In particular, IOP reduced at T2 and T3 with both MLT 1500 and 1000 without any significant differences (IOP reduction 22.9% vs. 17.3%, respectively, MLT1500 vs. MLT1000 at T2). The IOP returned to baseline values at T4 and T5 in both groups, with a reduction in topical medications administered from 2.5 ± 1.1 to 2.0 ± 1.2 to the 1500 mW group and from 2.4 ± 1.0 to 1.9 ± 1.0 to the 1000 mW group. At 1 h post-laser treatment, a transient IOP spike was registered among the MLT1500 group. There were no differences in CCT and ECC at any timepoint according to the laser powers. <b>Conclusions</b>: Over a 6-month follow-up period, 577 nm MLT at either 1500 or 1000 mW reduces IOP, enabling a stable reduction in the number of topical medications required for patients treated for POAG without any significant difference in terms of effectiveness and safety.https://www.mdpi.com/2075-1729/13/4/982glaucoma treatmenttrabeculoplastyopen-angle glaucomamicropulse yellow lasermicropulse laser trabeculoplastyintraocular pressure |
| spellingShingle | Tommaso Verdina Matteo Gironi Bruno Battaglia Michele Gentile Johanna Chester Shaniko Kaleci Gianluca Scatigna Rodolfo Mastropasqua Gian Maria Cavallini Micropulse Laser Trabeculoplasty with 577 nm Wavelength at 1500 or 1000 mW for Primary Open-Angle Glaucoma: A Pilot Study Life glaucoma treatment trabeculoplasty open-angle glaucoma micropulse yellow laser micropulse laser trabeculoplasty intraocular pressure |
| title | Micropulse Laser Trabeculoplasty with 577 nm Wavelength at 1500 or 1000 mW for Primary Open-Angle Glaucoma: A Pilot Study |
| title_full | Micropulse Laser Trabeculoplasty with 577 nm Wavelength at 1500 or 1000 mW for Primary Open-Angle Glaucoma: A Pilot Study |
| title_fullStr | Micropulse Laser Trabeculoplasty with 577 nm Wavelength at 1500 or 1000 mW for Primary Open-Angle Glaucoma: A Pilot Study |
| title_full_unstemmed | Micropulse Laser Trabeculoplasty with 577 nm Wavelength at 1500 or 1000 mW for Primary Open-Angle Glaucoma: A Pilot Study |
| title_short | Micropulse Laser Trabeculoplasty with 577 nm Wavelength at 1500 or 1000 mW for Primary Open-Angle Glaucoma: A Pilot Study |
| title_sort | micropulse laser trabeculoplasty with 577 nm wavelength at 1500 or 1000 mw for primary open angle glaucoma a pilot study |
| topic | glaucoma treatment trabeculoplasty open-angle glaucoma micropulse yellow laser micropulse laser trabeculoplasty intraocular pressure |
| url | https://www.mdpi.com/2075-1729/13/4/982 |
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