Effect of heat-moisture treated brown rice crackers on postprandial flow-mediated dilation in adults with mild endothelial dysfunction
Background: Endothelial dysfunction is an early pathophysiological feature and independent predictor of a poor prognosis in most forms of cardiovascular disease. We evaluated the effect of brown rice crackers (BR-C) on endothelial function. Methods: Effect of heat-moisture treated (HMT) -BR-C on pos...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022015729 |
| _version_ | 1828358263047979008 |
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| author | Kenichi Watanabe Masao Hirayama Somasundaram Arumugam Masayoshi Sugawara Hisanori Kato Sumiko Nakamura Ken'ichi Ohtsubo Hitoshi Matsumoto Yuri Nomi Noriyuki Homma Yoshifumi Fujii Naoto Murohashi Rajarajan A Thandavarayan Hiroshi Suzuki Kazuya Fujihara Satoru Kodama Hirohito Sone |
| author_facet | Kenichi Watanabe Masao Hirayama Somasundaram Arumugam Masayoshi Sugawara Hisanori Kato Sumiko Nakamura Ken'ichi Ohtsubo Hitoshi Matsumoto Yuri Nomi Noriyuki Homma Yoshifumi Fujii Naoto Murohashi Rajarajan A Thandavarayan Hiroshi Suzuki Kazuya Fujihara Satoru Kodama Hirohito Sone |
| author_sort | Kenichi Watanabe |
| collection | DOAJ |
| description | Background: Endothelial dysfunction is an early pathophysiological feature and independent predictor of a poor prognosis in most forms of cardiovascular disease. We evaluated the effect of brown rice crackers (BR-C) on endothelial function. Methods: Effect of heat-moisture treated (HMT) -BR-C on postprandial flow-mediated dilation (FMD) in adults with mild endothelial dysfunction was compared with that of BR-C and white rice crackers (WR-C) in 12 adults with mild endothelial dysfunction (less than 7.0% of FMD) by a randomized, single-blind, three-treatment three-period crossover trial (UMIN 000034898). Since we considered that the FMD increase was associated with the treatment of HMT-BR-C, we examined the effect of three possible factors: postprandial glucose levels, polyphenol content, and polyphenol release from the food matrix. Results: Mean pre-intake baseline FMD values of HMT-BR-C, BR-C, and WR-C were 4.9%, 5.1%, and 4.9%, respectively, and those values 1 h post-intake were 6.3%, 5.1%, and 4.8%, respectively. There was no difference in intergroup comparisons of FMD using Dunnett's multiple comparison test. There was a significant increase in FMD only in HMT-BR-C in intragroup comparisons (P = 0.042 by paired-t test). In comparison with BR-C, no significant difference was noted in the postprandial glucose level nor in the content of total polyphenols and ferulic acid derivatives in HMT-BR-C. However, the 70% ethanol extracted from HMT-BR-C contained a significantly larger amount of free and bound ferulic acids than from BR-C. Conclusion: HMT-BR-C intake increased the postprandial FMD response. |
| first_indexed | 2024-04-14T03:27:03Z |
| format | Article |
| id | doaj.art-49dd721fc1d44d34a78c40f959280464 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-14T03:27:03Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-49dd721fc1d44d34a78c40f9592804642022-12-22T02:15:08ZengElsevierHeliyon2405-84402022-08-0188e10284Effect of heat-moisture treated brown rice crackers on postprandial flow-mediated dilation in adults with mild endothelial dysfunctionKenichi Watanabe0Masao Hirayama1Somasundaram Arumugam2Masayoshi Sugawara3Hisanori Kato4Sumiko Nakamura5Ken'ichi Ohtsubo6Hitoshi Matsumoto7Yuri Nomi8Noriyuki Homma9Yoshifumi Fujii10Naoto Murohashi11Rajarajan A Thandavarayan12Hiroshi Suzuki13Kazuya Fujihara14Satoru Kodama15Hirohito Sone16Department of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Sciences, Japan; Corresponding author.Niigata Bio-Research Park Co., Ltd., JapanDepartment of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Sciences, Japan; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Kolkata, IndiaDepartment of Materials Engineering, National Institute of Technology, Nagaoka College, JapanGraduate School of Agriculture and Life Sciences, The University of Tokyo, JapanFaculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, JapanFaculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, JapanFaculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, JapanFaculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, JapanCereal Food Section, Niigata Agricultural Research Institute Food Research Center, JapanNiigata-Seifun Co., Ltd., JapanBourbon Institutes of Health, Bourbon Corporation, JapanDepartment of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Sciences, Japan; Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX 77030, USADepartment of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Sciences, JapanDepartment of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Sciences, JapanDepartment of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Sciences, JapanDepartment of Hematology, Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Sciences, JapanBackground: Endothelial dysfunction is an early pathophysiological feature and independent predictor of a poor prognosis in most forms of cardiovascular disease. We evaluated the effect of brown rice crackers (BR-C) on endothelial function. Methods: Effect of heat-moisture treated (HMT) -BR-C on postprandial flow-mediated dilation (FMD) in adults with mild endothelial dysfunction was compared with that of BR-C and white rice crackers (WR-C) in 12 adults with mild endothelial dysfunction (less than 7.0% of FMD) by a randomized, single-blind, three-treatment three-period crossover trial (UMIN 000034898). Since we considered that the FMD increase was associated with the treatment of HMT-BR-C, we examined the effect of three possible factors: postprandial glucose levels, polyphenol content, and polyphenol release from the food matrix. Results: Mean pre-intake baseline FMD values of HMT-BR-C, BR-C, and WR-C were 4.9%, 5.1%, and 4.9%, respectively, and those values 1 h post-intake were 6.3%, 5.1%, and 4.8%, respectively. There was no difference in intergroup comparisons of FMD using Dunnett's multiple comparison test. There was a significant increase in FMD only in HMT-BR-C in intragroup comparisons (P = 0.042 by paired-t test). In comparison with BR-C, no significant difference was noted in the postprandial glucose level nor in the content of total polyphenols and ferulic acid derivatives in HMT-BR-C. However, the 70% ethanol extracted from HMT-BR-C contained a significantly larger amount of free and bound ferulic acids than from BR-C. Conclusion: HMT-BR-C intake increased the postprandial FMD response.http://www.sciencedirect.com/science/article/pii/S2405844022015729Crossover trialHeat-moisture treated (HMT) brown rice crackerFlow-mediated dilation (FMD)PolyphenolsBlood glucose |
| spellingShingle | Kenichi Watanabe Masao Hirayama Somasundaram Arumugam Masayoshi Sugawara Hisanori Kato Sumiko Nakamura Ken'ichi Ohtsubo Hitoshi Matsumoto Yuri Nomi Noriyuki Homma Yoshifumi Fujii Naoto Murohashi Rajarajan A Thandavarayan Hiroshi Suzuki Kazuya Fujihara Satoru Kodama Hirohito Sone Effect of heat-moisture treated brown rice crackers on postprandial flow-mediated dilation in adults with mild endothelial dysfunction Heliyon Crossover trial Heat-moisture treated (HMT) brown rice cracker Flow-mediated dilation (FMD) Polyphenols Blood glucose |
| title | Effect of heat-moisture treated brown rice crackers on postprandial flow-mediated dilation in adults with mild endothelial dysfunction |
| title_full | Effect of heat-moisture treated brown rice crackers on postprandial flow-mediated dilation in adults with mild endothelial dysfunction |
| title_fullStr | Effect of heat-moisture treated brown rice crackers on postprandial flow-mediated dilation in adults with mild endothelial dysfunction |
| title_full_unstemmed | Effect of heat-moisture treated brown rice crackers on postprandial flow-mediated dilation in adults with mild endothelial dysfunction |
| title_short | Effect of heat-moisture treated brown rice crackers on postprandial flow-mediated dilation in adults with mild endothelial dysfunction |
| title_sort | effect of heat moisture treated brown rice crackers on postprandial flow mediated dilation in adults with mild endothelial dysfunction |
| topic | Crossover trial Heat-moisture treated (HMT) brown rice cracker Flow-mediated dilation (FMD) Polyphenols Blood glucose |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022015729 |
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