Case report: Area of focus in a case of malignant hypertension
Malignant hypertension (MH) is characterized by severe hypertension (usually grade 3) associated with fundoscopic changes (flame hemorrhages and/or papilledema), microangiopathy and disseminated intravascular coagulation. In addition encephalopathy, acute heart failure and acute deterioration in ren...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1108666/full |
| _version_ | 1797953722986266624 |
|---|---|
| author | Francesca Gaia Bosisio Francesca Gaia Bosisio Francesca Gaia Bosisio Desirè Mingardi Desirè Mingardi Desirè Mingardi Elisabetta Moretti Elisabetta Moretti Elisabetta Moretti Giorgia Muzi Giorgia Muzi Giorgia Muzi Francesco Russomanno Francesco Russomanno Nicola Tassani Nicola Tassani Nicola Tassani Deborah Stassaldi Claudia Agabiti Rosei Claudia Agabiti Rosei Carolina De Ciuceis Carolina De Ciuceis Massimo Salvetti Massimo Salvetti Maria Lorenza Muiesan Maria Lorenza Muiesan |
| author_facet | Francesca Gaia Bosisio Francesca Gaia Bosisio Francesca Gaia Bosisio Desirè Mingardi Desirè Mingardi Desirè Mingardi Elisabetta Moretti Elisabetta Moretti Elisabetta Moretti Giorgia Muzi Giorgia Muzi Giorgia Muzi Francesco Russomanno Francesco Russomanno Nicola Tassani Nicola Tassani Nicola Tassani Deborah Stassaldi Claudia Agabiti Rosei Claudia Agabiti Rosei Carolina De Ciuceis Carolina De Ciuceis Massimo Salvetti Massimo Salvetti Maria Lorenza Muiesan Maria Lorenza Muiesan |
| author_sort | Francesca Gaia Bosisio |
| collection | DOAJ |
| description | Malignant hypertension (MH) is characterized by severe hypertension (usually grade 3) associated with fundoscopic changes (flame hemorrhages and/or papilledema), microangiopathy and disseminated intravascular coagulation. In addition encephalopathy, acute heart failure and acute deterioration in renal function may be present. The term “malignant” reflects the very poor prognosis for this condition if untreated. When severe hypertension is associated with hypertension-mediated organ damage (HMOD) a life-threatening situation that requires immediate but careful intervention occurs (hypertensive emergency). In the last few years an increase in the number of patients with malignant hypertension has been observed, especially among those patients with black ethnicity. Limited access to treatment and the poor adherence to anti-hypertensive therapy may contribute to the development of hypertensive emergencies. It is considered appropriate to study patients in order to rule out thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. In fact, the microvascular damage caused by malignant hypertension can favor intravascular hemolysis like Thrombotic Microangiopathies (TMs). TMs may present in three different clinical conditions: typical hemolytic uremic syndrome (HUS), atypical hemolytic uremic syndrome (aHUS) and thrombotic thrombocytopenic purpura (TTP). TMs can arise in the context of other pathological processes, including malignant hypertension. |
| first_indexed | 2024-04-10T23:06:36Z |
| format | Article |
| id | doaj.art-49de297551044d39a1ea5750395d33b6 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-10T23:06:36Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-49de297551044d39a1ea5750395d33b62023-01-13T10:44:05ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-01-01910.3389/fcvm.2022.11086661108666Case report: Area of focus in a case of malignant hypertensionFrancesca Gaia Bosisio0Francesca Gaia Bosisio1Francesca Gaia Bosisio2Desirè Mingardi3Desirè Mingardi4Desirè Mingardi5Elisabetta Moretti6Elisabetta Moretti7Elisabetta Moretti8Giorgia Muzi9Giorgia Muzi10Giorgia Muzi11Francesco Russomanno12Francesco Russomanno13Nicola Tassani14Nicola Tassani15Nicola Tassani16Deborah Stassaldi17Claudia Agabiti Rosei18Claudia Agabiti Rosei19Carolina De Ciuceis20Carolina De Ciuceis21Massimo Salvetti22Massimo Salvetti23Maria Lorenza Muiesan24Maria Lorenza Muiesan25UOC 2 Medicina, ASST Spedali Civili di Brescia, Brescia, ItalyEmergency Medicine ASST Spedali Civili Brescia, Brescia, ItalyDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, ItalyUOC 2 Medicina, ASST Spedali Civili di Brescia, Brescia, ItalyEmergency Medicine ASST Spedali Civili Brescia, Brescia, ItalyDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, ItalyUOC 2 Medicina, ASST Spedali Civili di Brescia, Brescia, ItalyEmergency Medicine ASST Spedali Civili Brescia, Brescia, ItalyDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, ItalyUOC 2 Medicina, ASST Spedali Civili di Brescia, Brescia, ItalyEmergency Medicine ASST Spedali Civili Brescia, Brescia, ItalyDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, ItalyUOC 2 Medicina, ASST Spedali Civili di Brescia, Brescia, ItalyDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, ItalyUOC 2 Medicina, ASST Spedali Civili di Brescia, Brescia, ItalyEmergency Medicine ASST Spedali Civili Brescia, Brescia, ItalyDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, ItalyUOC 2 Medicina, ASST Spedali Civili di Brescia, Brescia, ItalyUOC 2 Medicina, ASST Spedali Civili di Brescia, Brescia, ItalyDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, ItalyUOC 2 Medicina, ASST Spedali Civili di Brescia, Brescia, ItalyDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, ItalyEmergency Medicine ASST Spedali Civili Brescia, Brescia, ItalyDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, ItalyUOC 2 Medicina, ASST Spedali Civili di Brescia, Brescia, ItalyDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, ItalyMalignant hypertension (MH) is characterized by severe hypertension (usually grade 3) associated with fundoscopic changes (flame hemorrhages and/or papilledema), microangiopathy and disseminated intravascular coagulation. In addition encephalopathy, acute heart failure and acute deterioration in renal function may be present. The term “malignant” reflects the very poor prognosis for this condition if untreated. When severe hypertension is associated with hypertension-mediated organ damage (HMOD) a life-threatening situation that requires immediate but careful intervention occurs (hypertensive emergency). In the last few years an increase in the number of patients with malignant hypertension has been observed, especially among those patients with black ethnicity. Limited access to treatment and the poor adherence to anti-hypertensive therapy may contribute to the development of hypertensive emergencies. It is considered appropriate to study patients in order to rule out thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. In fact, the microvascular damage caused by malignant hypertension can favor intravascular hemolysis like Thrombotic Microangiopathies (TMs). TMs may present in three different clinical conditions: typical hemolytic uremic syndrome (HUS), atypical hemolytic uremic syndrome (aHUS) and thrombotic thrombocytopenic purpura (TTP). TMs can arise in the context of other pathological processes, including malignant hypertension.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1108666/fullmalignant hypertensionhypertensive emergencyorgan damageatypical hemolytic uremic syndromethrombotic microangiopathiesleft ventricular hypertrophy |
| spellingShingle | Francesca Gaia Bosisio Francesca Gaia Bosisio Francesca Gaia Bosisio Desirè Mingardi Desirè Mingardi Desirè Mingardi Elisabetta Moretti Elisabetta Moretti Elisabetta Moretti Giorgia Muzi Giorgia Muzi Giorgia Muzi Francesco Russomanno Francesco Russomanno Nicola Tassani Nicola Tassani Nicola Tassani Deborah Stassaldi Claudia Agabiti Rosei Claudia Agabiti Rosei Carolina De Ciuceis Carolina De Ciuceis Massimo Salvetti Massimo Salvetti Maria Lorenza Muiesan Maria Lorenza Muiesan Case report: Area of focus in a case of malignant hypertension Frontiers in Cardiovascular Medicine malignant hypertension hypertensive emergency organ damage atypical hemolytic uremic syndrome thrombotic microangiopathies left ventricular hypertrophy |
| title | Case report: Area of focus in a case of malignant hypertension |
| title_full | Case report: Area of focus in a case of malignant hypertension |
| title_fullStr | Case report: Area of focus in a case of malignant hypertension |
| title_full_unstemmed | Case report: Area of focus in a case of malignant hypertension |
| title_short | Case report: Area of focus in a case of malignant hypertension |
| title_sort | case report area of focus in a case of malignant hypertension |
| topic | malignant hypertension hypertensive emergency organ damage atypical hemolytic uremic syndrome thrombotic microangiopathies left ventricular hypertrophy |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1108666/full |
| work_keys_str_mv | AT francescagaiabosisio casereportareaoffocusinacaseofmalignanthypertension AT francescagaiabosisio casereportareaoffocusinacaseofmalignanthypertension AT francescagaiabosisio casereportareaoffocusinacaseofmalignanthypertension AT desiremingardi casereportareaoffocusinacaseofmalignanthypertension AT desiremingardi casereportareaoffocusinacaseofmalignanthypertension AT desiremingardi casereportareaoffocusinacaseofmalignanthypertension AT elisabettamoretti casereportareaoffocusinacaseofmalignanthypertension AT elisabettamoretti casereportareaoffocusinacaseofmalignanthypertension AT elisabettamoretti casereportareaoffocusinacaseofmalignanthypertension AT giorgiamuzi casereportareaoffocusinacaseofmalignanthypertension AT giorgiamuzi casereportareaoffocusinacaseofmalignanthypertension AT giorgiamuzi casereportareaoffocusinacaseofmalignanthypertension AT francescorussomanno casereportareaoffocusinacaseofmalignanthypertension AT francescorussomanno casereportareaoffocusinacaseofmalignanthypertension AT nicolatassani casereportareaoffocusinacaseofmalignanthypertension AT nicolatassani casereportareaoffocusinacaseofmalignanthypertension AT nicolatassani casereportareaoffocusinacaseofmalignanthypertension AT deborahstassaldi casereportareaoffocusinacaseofmalignanthypertension AT claudiaagabitirosei casereportareaoffocusinacaseofmalignanthypertension AT claudiaagabitirosei casereportareaoffocusinacaseofmalignanthypertension AT carolinadeciuceis casereportareaoffocusinacaseofmalignanthypertension AT carolinadeciuceis casereportareaoffocusinacaseofmalignanthypertension AT massimosalvetti casereportareaoffocusinacaseofmalignanthypertension AT massimosalvetti casereportareaoffocusinacaseofmalignanthypertension AT marialorenzamuiesan casereportareaoffocusinacaseofmalignanthypertension AT marialorenzamuiesan casereportareaoffocusinacaseofmalignanthypertension |