Bone morphogenetic protein 4 rescues the bone regenerative potential of old muscle-derived stem cells via regulation of cell cycle inhibitors

Bone morphogenetic protein 4 rescues the bone regenerative potential of old muscle-derived stem cells via regulation of cell cycle inhibitors

Abstract Background Bone morphogenetic protein 4 (BMP4) promotes the osteogenic differentiation and the bone regenerative potential of muscle-derived stem cells (MDSCs). BMP4 also promotes the self-renewal of both embryonic and somatic stem cells; however, BMP4 signaling activity significantly decre...

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Bibliographic Details
Main Authors: Haizi Cheng, Xueqin Gao, Matthieu Huard, Aiping Lu, Joseph J. Ruzbarsky, Sara Amra, Bing Wang, Johnny Huard
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Stem Cell Research & Therapy
Subjects:
Bone morphogenetic protein 4
Bone regeneration
P16
P18
Aging
Muscle-derived stem cells
Online Access:https://doi.org/10.1186/s13287-022-03047-z

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