Female Scent Activated Expression of Arginase1 and Inducible NO-Synthetase in Lung of BALB/c Male Mice
Scent signals play an important role in the life of rodents. The scent of the opposite sex can modulate immunity. In mice populations with natural specific pathogens, in males, the scent of a female leads to a redistribution of leukocytes between the lung and the blood, resistance to the influenza v...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Animals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2615/11/6/1756 |
| _version_ | 1797530385016422400 |
|---|---|
| author | Olga V. Gvozdeva Kseniya M. Achasova Nadezhda A. Litvinova Elena N. Kozhevnikova Ekaterina A. Litvinova |
| author_facet | Olga V. Gvozdeva Kseniya M. Achasova Nadezhda A. Litvinova Elena N. Kozhevnikova Ekaterina A. Litvinova |
| author_sort | Olga V. Gvozdeva |
| collection | DOAJ |
| description | Scent signals play an important role in the life of rodents. The scent of the opposite sex can modulate immunity. In mice populations with natural specific pathogens, in males, the scent of a female leads to a redistribution of leukocytes between the lung and the blood, resistance to the influenza virus, and a decrease in antibody production, but not in the development of inflammation induced by bacterial endotoxins. This study demonstrates the effect of the scent of soiled bedding of specific pathogen-free (SPF) status female mice on the percentage of different types of leukocytes in the blood, the expression of <i>Nos2</i>, <i>Arg1</i>, and <i>Foxp3</i> genes, and the presence of M1/M2 macrophages in the lungs of male BALB/c mice. The scent of the female SPF mice caused a redistribution between T- and B-cells in the blood, the increase in the expression of <i>Nos2</i>, <i>Arg1</i> genes, and the percentage of M1 type macrophages in the lung, but did not affect the different types of T-cells in the periphery or the lungs. Activation of macrophages in the lung is part of mucosal immunity, which is necessary for males as an adaptive mechanism to prevent potential infection during the search for a sexual partner. |
| first_indexed | 2024-03-10T10:28:10Z |
| format | Article |
| id | doaj.art-49e3f5d7dd5641da821b8ab456ecc36b |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T10:28:10Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-49e3f5d7dd5641da821b8ab456ecc36b2023-11-21T23:49:16ZengMDPI AGAnimals2076-26152021-06-01116175610.3390/ani11061756Female Scent Activated Expression of Arginase1 and Inducible NO-Synthetase in Lung of BALB/c Male MiceOlga V. Gvozdeva0Kseniya M. Achasova1Nadezhda A. Litvinova2Elena N. Kozhevnikova3Ekaterina A. Litvinova4Siberian Federal Scientific Centre of Agro-BioTechnologies of the Russian Academy of Sciences, P.O. Box 267, 630501 Krasnoobsk, RussiaSiberian Federal Scientific Centre of Agro-BioTechnologies of the Russian Academy of Sciences, P.O. Box 267, 630501 Krasnoobsk, RussiaFaculty of General Medicine, Kemerovo State Medical University, 650001 Kemerovo, RussiaSiberian Federal Scientific Centre of Agro-BioTechnologies of the Russian Academy of Sciences, P.O. Box 267, 630501 Krasnoobsk, RussiaSiberian Federal Scientific Centre of Agro-BioTechnologies of the Russian Academy of Sciences, P.O. Box 267, 630501 Krasnoobsk, RussiaScent signals play an important role in the life of rodents. The scent of the opposite sex can modulate immunity. In mice populations with natural specific pathogens, in males, the scent of a female leads to a redistribution of leukocytes between the lung and the blood, resistance to the influenza virus, and a decrease in antibody production, but not in the development of inflammation induced by bacterial endotoxins. This study demonstrates the effect of the scent of soiled bedding of specific pathogen-free (SPF) status female mice on the percentage of different types of leukocytes in the blood, the expression of <i>Nos2</i>, <i>Arg1</i>, and <i>Foxp3</i> genes, and the presence of M1/M2 macrophages in the lungs of male BALB/c mice. The scent of the female SPF mice caused a redistribution between T- and B-cells in the blood, the increase in the expression of <i>Nos2</i>, <i>Arg1</i> genes, and the percentage of M1 type macrophages in the lung, but did not affect the different types of T-cells in the periphery or the lungs. Activation of macrophages in the lung is part of mucosal immunity, which is necessary for males as an adaptive mechanism to prevent potential infection during the search for a sexual partner.https://www.mdpi.com/2076-2615/11/6/1756arginase1inducible NO-synthetasefemale scentbarrier immunityolfactory searchbreeding behavior |
| spellingShingle | Olga V. Gvozdeva Kseniya M. Achasova Nadezhda A. Litvinova Elena N. Kozhevnikova Ekaterina A. Litvinova Female Scent Activated Expression of Arginase1 and Inducible NO-Synthetase in Lung of BALB/c Male Mice Animals arginase1 inducible NO-synthetase female scent barrier immunity olfactory search breeding behavior |
| title | Female Scent Activated Expression of Arginase1 and Inducible NO-Synthetase in Lung of BALB/c Male Mice |
| title_full | Female Scent Activated Expression of Arginase1 and Inducible NO-Synthetase in Lung of BALB/c Male Mice |
| title_fullStr | Female Scent Activated Expression of Arginase1 and Inducible NO-Synthetase in Lung of BALB/c Male Mice |
| title_full_unstemmed | Female Scent Activated Expression of Arginase1 and Inducible NO-Synthetase in Lung of BALB/c Male Mice |
| title_short | Female Scent Activated Expression of Arginase1 and Inducible NO-Synthetase in Lung of BALB/c Male Mice |
| title_sort | female scent activated expression of arginase1 and inducible no synthetase in lung of balb c male mice |
| topic | arginase1 inducible NO-synthetase female scent barrier immunity olfactory search breeding behavior |
| url | https://www.mdpi.com/2076-2615/11/6/1756 |
| work_keys_str_mv | AT olgavgvozdeva femalescentactivatedexpressionofarginase1andinduciblenosynthetaseinlungofbalbcmalemice AT kseniyamachasova femalescentactivatedexpressionofarginase1andinduciblenosynthetaseinlungofbalbcmalemice AT nadezhdaalitvinova femalescentactivatedexpressionofarginase1andinduciblenosynthetaseinlungofbalbcmalemice AT elenankozhevnikova femalescentactivatedexpressionofarginase1andinduciblenosynthetaseinlungofbalbcmalemice AT ekaterinaalitvinova femalescentactivatedexpressionofarginase1andinduciblenosynthetaseinlungofbalbcmalemice |