Mild to moderate clinical course of COVID-19 infection in patients with common variable immune deficiency
The association of immunocompromised patients and severity of COVID-19 infection is not well established. According to the Centers for Disease Control and Prevention (CDC), primary immune deficiencies (PIDs) are among the conditions that can predispose to a more severe course of COVID-19. We report...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2023-01-01
|
| Series: | Central European Journal of Immunology |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Mild-to-moderate-clinical-course-of-COVID-19-infection-in-patients-with-common-variable-immune-deficiency,10,49888,1,1.html |
| _version_ | 1797842698187571200 |
|---|---|
| author | Spaska Lesichkova Snezhina Mihailova Elisaveta Naumova Petya Yankova Yana Krasteva Ralitsa Marinova |
| author_facet | Spaska Lesichkova Snezhina Mihailova Elisaveta Naumova Petya Yankova Yana Krasteva Ralitsa Marinova |
| author_sort | Spaska Lesichkova |
| collection | DOAJ |
| description | The association of immunocompromised patients and severity of COVID-19 infection is not well established. According to the Centers for Disease Control and Prevention (CDC), primary immune deficiencies (PIDs) are among the conditions that can predispose to a more severe course of COVID-19. We report the clinical course and immunological evaluation of five patients with common variable immune deficiency (CVID) who have experienced SARS-CoV-2 virus. Here we assess the severity of the infection, the immunophenotypic profile of the major lymphocyte subgroups, the nonspecific T-cell functional capacity and the SARS-CoV-2 specific effector T-cell immune response. Our results showed that the course of COVID-19 infection in CVID patients was mild to moderate and none of them developed a critical form of the disease. All patients developed a specific SARS-CoV-2 T cell immune response. Lymphopenia as well as impaired T-cell response prior to COVID-19 appeared to be related to a more severe course of the infection. Data on a good specific T cell response against SARS-CoV-2 in CVID patients will help to make the right vaccination decision and establish its efficacy. Clinical outcome even in these individual cases was in agreement with the therapeutic recommendations underlining that regular maintenance with subcutaneous immunoglobulins can be beneficial against immune system overreaction and a severe disease course and convalescent plasma is a treatment option in patients with CVID and COVID-19. |
| first_indexed | 2024-04-09T16:52:14Z |
| format | Article |
| id | doaj.art-49e689b7e7624ead94cedc3c1b7245b6 |
| institution | Directory Open Access Journal |
| issn | 1426-3912 1644-4124 |
| language | English |
| last_indexed | 2024-04-09T16:52:14Z |
| publishDate | 2023-01-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Central European Journal of Immunology |
| spelling | doaj.art-49e689b7e7624ead94cedc3c1b7245b62023-04-21T09:59:34ZengTermedia Publishing HouseCentral European Journal of Immunology1426-39121644-41242023-01-0147435736110.5114/ceji.2022.12407949888Mild to moderate clinical course of COVID-19 infection in patients with common variable immune deficiencySpaska LesichkovaSnezhina MihailovaElisaveta NaumovaPetya YankovaYana KrastevaRalitsa MarinovaThe association of immunocompromised patients and severity of COVID-19 infection is not well established. According to the Centers for Disease Control and Prevention (CDC), primary immune deficiencies (PIDs) are among the conditions that can predispose to a more severe course of COVID-19. We report the clinical course and immunological evaluation of five patients with common variable immune deficiency (CVID) who have experienced SARS-CoV-2 virus. Here we assess the severity of the infection, the immunophenotypic profile of the major lymphocyte subgroups, the nonspecific T-cell functional capacity and the SARS-CoV-2 specific effector T-cell immune response. Our results showed that the course of COVID-19 infection in CVID patients was mild to moderate and none of them developed a critical form of the disease. All patients developed a specific SARS-CoV-2 T cell immune response. Lymphopenia as well as impaired T-cell response prior to COVID-19 appeared to be related to a more severe course of the infection. Data on a good specific T cell response against SARS-CoV-2 in CVID patients will help to make the right vaccination decision and establish its efficacy. Clinical outcome even in these individual cases was in agreement with the therapeutic recommendations underlining that regular maintenance with subcutaneous immunoglobulins can be beneficial against immune system overreaction and a severe disease course and convalescent plasma is a treatment option in patients with CVID and COVID-19.https://www.termedia.pl/Mild-to-moderate-clinical-course-of-COVID-19-infection-in-patients-with-common-variable-immune-deficiency,10,49888,1,1.htmlcovid-19 infection common variable immune deficiency t cell immune response |
| spellingShingle | Spaska Lesichkova Snezhina Mihailova Elisaveta Naumova Petya Yankova Yana Krasteva Ralitsa Marinova Mild to moderate clinical course of COVID-19 infection in patients with common variable immune deficiency Central European Journal of Immunology covid-19 infection common variable immune deficiency t cell immune response |
| title | Mild to moderate clinical course of COVID-19 infection in patients with common variable immune deficiency |
| title_full | Mild to moderate clinical course of COVID-19 infection in patients with common variable immune deficiency |
| title_fullStr | Mild to moderate clinical course of COVID-19 infection in patients with common variable immune deficiency |
| title_full_unstemmed | Mild to moderate clinical course of COVID-19 infection in patients with common variable immune deficiency |
| title_short | Mild to moderate clinical course of COVID-19 infection in patients with common variable immune deficiency |
| title_sort | mild to moderate clinical course of covid 19 infection in patients with common variable immune deficiency |
| topic | covid-19 infection common variable immune deficiency t cell immune response |
| url | https://www.termedia.pl/Mild-to-moderate-clinical-course-of-COVID-19-infection-in-patients-with-common-variable-immune-deficiency,10,49888,1,1.html |
| work_keys_str_mv | AT spaskalesichkova mildtomoderateclinicalcourseofcovid19infectioninpatientswithcommonvariableimmunedeficiency AT snezhinamihailova mildtomoderateclinicalcourseofcovid19infectioninpatientswithcommonvariableimmunedeficiency AT elisavetanaumova mildtomoderateclinicalcourseofcovid19infectioninpatientswithcommonvariableimmunedeficiency AT petyayankova mildtomoderateclinicalcourseofcovid19infectioninpatientswithcommonvariableimmunedeficiency AT yanakrasteva mildtomoderateclinicalcourseofcovid19infectioninpatientswithcommonvariableimmunedeficiency AT ralitsamarinova mildtomoderateclinicalcourseofcovid19infectioninpatientswithcommonvariableimmunedeficiency |