The characteristics and medical applications of antler stem cells
Abstract Antlers are the only fully regenerable mammalian appendages whose annual renewal is initiated by antler stem cells (ASCs), defined as a specialized type of mesenchymal stem cells (MSCs) with embryonic stem cell properties. ASCs possess the same biological features as MSCs, including the cap...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-023-03456-8 |
| _version_ | 1797453687654711296 |
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| author | Qi Liu Jiannan Li Jinghui Chang Yu Guo Dacheng Wen |
| author_facet | Qi Liu Jiannan Li Jinghui Chang Yu Guo Dacheng Wen |
| author_sort | Qi Liu |
| collection | DOAJ |
| description | Abstract Antlers are the only fully regenerable mammalian appendages whose annual renewal is initiated by antler stem cells (ASCs), defined as a specialized type of mesenchymal stem cells (MSCs) with embryonic stem cell properties. ASCs possess the same biological features as MSCs, including the capacity for self-renewal and multidirectional differentiation, immunomodulatory functions, and the maintenance of stem cell characteristics after multiple passages. Several preclinical studies have shown that ASCs exhibit promising potential in wound healing, bone repair, osteoarthritis, anti-tissue fibrosis, anti-aging, and hair regeneration. Medical applications based on ASCs and ASC-derived molecules provide a new source of stem cells and therapeutic modalities for regenerative medicine. This review begins with a brief description of antler regeneration and the role of ASCs. Then, the properties and advantages of ASCs are described. Finally, medical research advances regarding ASCs are summarized, and the prospects and challenges of ASCs are highlighted. |
| first_indexed | 2024-03-09T15:26:12Z |
| format | Article |
| id | doaj.art-49e8f49f118c4bae892343c52ec60c3c |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-03-09T15:26:12Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-49e8f49f118c4bae892343c52ec60c3c2023-11-26T12:30:49ZengBMCStem Cell Research & Therapy1757-65122023-08-0114111810.1186/s13287-023-03456-8The characteristics and medical applications of antler stem cellsQi Liu0Jiannan Li1Jinghui Chang2Yu Guo3Dacheng Wen4Department of Colorectal and Anal Surgery, The Second Hospital of Jilin UniversityDepartment of Colorectal and Anal Surgery, The Second Hospital of Jilin UniversityDepartment of Colorectal and Anal Surgery, The Second Hospital of Jilin UniversityDepartment of Colorectal and Anal Surgery, The Second Hospital of Jilin UniversityDepartment of Gastrointestinal Nutrition and Hernia Surgery, The Second Hospital of Jilin UniversityAbstract Antlers are the only fully regenerable mammalian appendages whose annual renewal is initiated by antler stem cells (ASCs), defined as a specialized type of mesenchymal stem cells (MSCs) with embryonic stem cell properties. ASCs possess the same biological features as MSCs, including the capacity for self-renewal and multidirectional differentiation, immunomodulatory functions, and the maintenance of stem cell characteristics after multiple passages. Several preclinical studies have shown that ASCs exhibit promising potential in wound healing, bone repair, osteoarthritis, anti-tissue fibrosis, anti-aging, and hair regeneration. Medical applications based on ASCs and ASC-derived molecules provide a new source of stem cells and therapeutic modalities for regenerative medicine. This review begins with a brief description of antler regeneration and the role of ASCs. Then, the properties and advantages of ASCs are described. Finally, medical research advances regarding ASCs are summarized, and the prospects and challenges of ASCs are highlighted.https://doi.org/10.1186/s13287-023-03456-8AntlerStem cellsMedical applications |
| spellingShingle | Qi Liu Jiannan Li Jinghui Chang Yu Guo Dacheng Wen The characteristics and medical applications of antler stem cells Stem Cell Research & Therapy Antler Stem cells Medical applications |
| title | The characteristics and medical applications of antler stem cells |
| title_full | The characteristics and medical applications of antler stem cells |
| title_fullStr | The characteristics and medical applications of antler stem cells |
| title_full_unstemmed | The characteristics and medical applications of antler stem cells |
| title_short | The characteristics and medical applications of antler stem cells |
| title_sort | characteristics and medical applications of antler stem cells |
| topic | Antler Stem cells Medical applications |
| url | https://doi.org/10.1186/s13287-023-03456-8 |
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