The Evaluation of Left Ventricle Ischemic Extent in Patients with Significantly Suspicious Cardiovascular Disease by <sup>99m</sup>Tc-Sestamibi Dynamic SPECT/CT and Myocardial Perfusion Imaging: A Head-to-Head Comparison
Heart disease is the second most common cause of mortality in Taiwan, mainly coronary artery disease (CAD).Quantitative coronary blood flow has been collected by dynamic single-photon emission computed tomography (Dynamic SPECT/CT) for CAD diagnosis in previous studies. However, few studies defined...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/6/1101 |
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| author | Hung-Pin Chan Chin-Chuan Chang Chin Hu Wen-Hwa Wang Nan-Jing Peng Yu-Chang Tyan Ming-Hui Yang |
| author_facet | Hung-Pin Chan Chin-Chuan Chang Chin Hu Wen-Hwa Wang Nan-Jing Peng Yu-Chang Tyan Ming-Hui Yang |
| author_sort | Hung-Pin Chan |
| collection | DOAJ |
| description | Heart disease is the second most common cause of mortality in Taiwan, mainly coronary artery disease (CAD).Quantitative coronary blood flow has been collected by dynamic single-photon emission computed tomography (Dynamic SPECT/CT) for CAD diagnosis in previous studies. However, few studies defined the extent of left ventricle (LV) ischemia on Dynamic SPECT/CT for predicting significant coronary artery stenosis. This study evaluates the extent of LV ischemic blockage in patients suspected of CAD who were referred by cardiologists. A total of 181 patients with suspected CAD were enrolled. They underwent <sup>99m</sup>Tc-Sestamibi (MIBI) Dynamic SPECT/CT survey before cardiac intervention. Dynamic SPECT/CT has better sensitivity (88%), specificity (96%), and accuracy (94%) compared with those of semi-quantitative MIBI MPI (more than 10%). Results indicated that5% of the LV ischemic extent can yield positive PCI results (>70% stenosis in coronary arteries) compared with the moderate abnormal extent of at least 15% of LV. When the percentage of combined moderate abnormal extent and ischemia extent of LV reaches 27.3%, positive PCI results may be indicated. This study revealed Dynamic SPECT/CT has greater sensitivity, specificity, and accuracy as compared with MPI. Thus, the severity of abnormal perfusion extent of LV on Dynamic SPECT/CT might be beneficial to predict positive PCI results in patients with significant suspicion CAD. |
| first_indexed | 2024-03-10T10:22:21Z |
| format | Article |
| id | doaj.art-49e9a9a3660345cab61e375771a08068 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T10:22:21Z |
| publishDate | 2021-06-01 |
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| series | Diagnostics |
| spelling | doaj.art-49e9a9a3660345cab61e375771a080682023-11-22T00:20:23ZengMDPI AGDiagnostics2075-44182021-06-01116110110.3390/diagnostics11061101The Evaluation of Left Ventricle Ischemic Extent in Patients with Significantly Suspicious Cardiovascular Disease by <sup>99m</sup>Tc-Sestamibi Dynamic SPECT/CT and Myocardial Perfusion Imaging: A Head-to-Head ComparisonHung-Pin Chan0Chin-Chuan Chang1Chin Hu2Wen-Hwa Wang3Nan-Jing Peng4Yu-Chang Tyan5Ming-Hui Yang6Department of Nuclear Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanDepartment of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, TaiwanDepartment of Nuclear Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanDepartment of Internal Medicine, Division of Cardiology, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanDepartment of Nuclear Medicine, Taipei Veterans General Hospital, Taipei 112, TaiwanResearch Center for Environmental Medicine, Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanHeart disease is the second most common cause of mortality in Taiwan, mainly coronary artery disease (CAD).Quantitative coronary blood flow has been collected by dynamic single-photon emission computed tomography (Dynamic SPECT/CT) for CAD diagnosis in previous studies. However, few studies defined the extent of left ventricle (LV) ischemia on Dynamic SPECT/CT for predicting significant coronary artery stenosis. This study evaluates the extent of LV ischemic blockage in patients suspected of CAD who were referred by cardiologists. A total of 181 patients with suspected CAD were enrolled. They underwent <sup>99m</sup>Tc-Sestamibi (MIBI) Dynamic SPECT/CT survey before cardiac intervention. Dynamic SPECT/CT has better sensitivity (88%), specificity (96%), and accuracy (94%) compared with those of semi-quantitative MIBI MPI (more than 10%). Results indicated that5% of the LV ischemic extent can yield positive PCI results (>70% stenosis in coronary arteries) compared with the moderate abnormal extent of at least 15% of LV. When the percentage of combined moderate abnormal extent and ischemia extent of LV reaches 27.3%, positive PCI results may be indicated. This study revealed Dynamic SPECT/CT has greater sensitivity, specificity, and accuracy as compared with MPI. Thus, the severity of abnormal perfusion extent of LV on Dynamic SPECT/CT might be beneficial to predict positive PCI results in patients with significant suspicion CAD.https://www.mdpi.com/2075-4418/11/6/1101CADDynamic SPECT/CTmyocardial perfusion imagingLV ischemic extent |
| spellingShingle | Hung-Pin Chan Chin-Chuan Chang Chin Hu Wen-Hwa Wang Nan-Jing Peng Yu-Chang Tyan Ming-Hui Yang The Evaluation of Left Ventricle Ischemic Extent in Patients with Significantly Suspicious Cardiovascular Disease by <sup>99m</sup>Tc-Sestamibi Dynamic SPECT/CT and Myocardial Perfusion Imaging: A Head-to-Head Comparison Diagnostics CAD Dynamic SPECT/CT myocardial perfusion imaging LV ischemic extent |
| title | The Evaluation of Left Ventricle Ischemic Extent in Patients with Significantly Suspicious Cardiovascular Disease by <sup>99m</sup>Tc-Sestamibi Dynamic SPECT/CT and Myocardial Perfusion Imaging: A Head-to-Head Comparison |
| title_full | The Evaluation of Left Ventricle Ischemic Extent in Patients with Significantly Suspicious Cardiovascular Disease by <sup>99m</sup>Tc-Sestamibi Dynamic SPECT/CT and Myocardial Perfusion Imaging: A Head-to-Head Comparison |
| title_fullStr | The Evaluation of Left Ventricle Ischemic Extent in Patients with Significantly Suspicious Cardiovascular Disease by <sup>99m</sup>Tc-Sestamibi Dynamic SPECT/CT and Myocardial Perfusion Imaging: A Head-to-Head Comparison |
| title_full_unstemmed | The Evaluation of Left Ventricle Ischemic Extent in Patients with Significantly Suspicious Cardiovascular Disease by <sup>99m</sup>Tc-Sestamibi Dynamic SPECT/CT and Myocardial Perfusion Imaging: A Head-to-Head Comparison |
| title_short | The Evaluation of Left Ventricle Ischemic Extent in Patients with Significantly Suspicious Cardiovascular Disease by <sup>99m</sup>Tc-Sestamibi Dynamic SPECT/CT and Myocardial Perfusion Imaging: A Head-to-Head Comparison |
| title_sort | evaluation of left ventricle ischemic extent in patients with significantly suspicious cardiovascular disease by sup 99m sup tc sestamibi dynamic spect ct and myocardial perfusion imaging a head to head comparison |
| topic | CAD Dynamic SPECT/CT myocardial perfusion imaging LV ischemic extent |
| url | https://www.mdpi.com/2075-4418/11/6/1101 |
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