Genome-wide quantification of copy-number aberration impact on gene expression in ovarian high-grade serous carcinoma

Genome-wide quantification of copy-number aberration impact on gene expression in ovarian high-grade serous carcinoma

Abstract Copy-number alterations (CNAs) are a hallmark of cancer and can regulate cancer cell states via altered gene expression values. Herein, we have developed a copy-number impact (CNI) analysis method that quantifies the degree to which a gene expression value is impacted by CNAs and leveraged...

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Bibliographic Details
Main Authors: Sanaz Jamalzadeh, Jun Dai, Kari Lavikka, Yilin Li, Jing Jiang, Kaisa Huhtinen, Anni Virtanen, Jaana Oikkonen, Sakari Hietanen, Johanna Hynninen, Anna Vähärautio, Antti Häkkinen, Sampsa Hautaniemi
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Cancer
Subjects:
Copy-number alterations
Gene expression
Statistical modeling
Data integration
Pathway analysis
Ovarian cancer
Online Access:https://doi.org/10.1186/s12885-024-11895-6

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