Circulating tumor cells clusters and their role in Breast cancer metastasis; a review of literature
Abstract Breast cancer is a significant and deadly threat to women globally. Moreover, Breast cancer metastasis is a complicated process involving multiple biological stages, which is considered a substantial cause of death, where cancer cells spread from the original tumor to other organs in the bo...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2024-04-01
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| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-024-00949-7 |
| _version_ | 1827291446007300096 |
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| author | Zeinab S. Sayed Mohamed G. Khattap Mostafa A. Madkour Noha S. Yasen Hanan A. Elbary Reem A. Elsayed Dalia A. Abdelkawy Al-Hassan Soliman Wadan Islam Omar Mohamed H. Nafady |
| author_facet | Zeinab S. Sayed Mohamed G. Khattap Mostafa A. Madkour Noha S. Yasen Hanan A. Elbary Reem A. Elsayed Dalia A. Abdelkawy Al-Hassan Soliman Wadan Islam Omar Mohamed H. Nafady |
| author_sort | Zeinab S. Sayed |
| collection | DOAJ |
| description | Abstract Breast cancer is a significant and deadly threat to women globally. Moreover, Breast cancer metastasis is a complicated process involving multiple biological stages, which is considered a substantial cause of death, where cancer cells spread from the original tumor to other organs in the body—representing the primary mortality factor. Circulating tumor cells (CTCs) are cancer cells detached from the primary or metastatic tumor and enter the bloodstream, allowing them to establish new metastatic sites. CTCs can travel alone or in groups called CTC clusters. Studies have shown that CTC clusters have more potential for metastasis and a poorer prognosis than individual CTCs in breast cancer patients. However, our understanding of CTC clusters' formation, structure, function, and detection is still limited. This review summarizes the current knowledge of CTC clusters' biological properties, isolation, and prognostic significance in breast cancer. It also highlights the challenges and future directions for research and clinical application of CTC clusters. |
| first_indexed | 2024-04-24T12:38:15Z |
| format | Article |
| id | doaj.art-49eda8b2b9a546748f114f1ff364d84f |
| institution | Directory Open Access Journal |
| issn | 2730-6011 |
| language | English |
| last_indexed | 2024-04-24T12:38:15Z |
| publishDate | 2024-04-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj.art-49eda8b2b9a546748f114f1ff364d84f2024-04-07T11:22:37ZengSpringerDiscover Oncology2730-60112024-04-0115112410.1007/s12672-024-00949-7Circulating tumor cells clusters and their role in Breast cancer metastasis; a review of literatureZeinab S. Sayed0Mohamed G. Khattap1Mostafa A. Madkour2Noha S. Yasen3Hanan A. Elbary4Reem A. Elsayed5Dalia A. Abdelkawy6Al-Hassan Soliman Wadan7Islam Omar8Mohamed H. Nafady9Faculty of Applied Medical Science, Misr University for Science and TechnologyTechnology of Radiology and Medical Imaging Program, Faculty of Applied Health Sciences Technology, Galala UniversityFaculty of Medicine, Benha UniversityRadiology and Imaging Technology Department, Faculty of Applied Health Science Technology, Delta University for Science and TechnologyFaculty of Applied Medical Science, Misr University for Science and TechnologyFaculty of Applied Medical Science, Misr University for Science and TechnologyFaculty of Applied Medical Science, Misr University for Science and TechnologyFaculty of Dentistry, Sinai UniversityFaculty of Pharmacy, South Valley UniversityRadiation Sciences Department, Medical Research Institute, Alexandria UniversityAbstract Breast cancer is a significant and deadly threat to women globally. Moreover, Breast cancer metastasis is a complicated process involving multiple biological stages, which is considered a substantial cause of death, where cancer cells spread from the original tumor to other organs in the body—representing the primary mortality factor. Circulating tumor cells (CTCs) are cancer cells detached from the primary or metastatic tumor and enter the bloodstream, allowing them to establish new metastatic sites. CTCs can travel alone or in groups called CTC clusters. Studies have shown that CTC clusters have more potential for metastasis and a poorer prognosis than individual CTCs in breast cancer patients. However, our understanding of CTC clusters' formation, structure, function, and detection is still limited. This review summarizes the current knowledge of CTC clusters' biological properties, isolation, and prognostic significance in breast cancer. It also highlights the challenges and future directions for research and clinical application of CTC clusters.https://doi.org/10.1007/s12672-024-00949-7Breast cancerMetastasisCirculating tumor cellsCTC clustersCTC detectionCTC biology |
| spellingShingle | Zeinab S. Sayed Mohamed G. Khattap Mostafa A. Madkour Noha S. Yasen Hanan A. Elbary Reem A. Elsayed Dalia A. Abdelkawy Al-Hassan Soliman Wadan Islam Omar Mohamed H. Nafady Circulating tumor cells clusters and their role in Breast cancer metastasis; a review of literature Discover Oncology Breast cancer Metastasis Circulating tumor cells CTC clusters CTC detection CTC biology |
| title | Circulating tumor cells clusters and their role in Breast cancer metastasis; a review of literature |
| title_full | Circulating tumor cells clusters and their role in Breast cancer metastasis; a review of literature |
| title_fullStr | Circulating tumor cells clusters and their role in Breast cancer metastasis; a review of literature |
| title_full_unstemmed | Circulating tumor cells clusters and their role in Breast cancer metastasis; a review of literature |
| title_short | Circulating tumor cells clusters and their role in Breast cancer metastasis; a review of literature |
| title_sort | circulating tumor cells clusters and their role in breast cancer metastasis a review of literature |
| topic | Breast cancer Metastasis Circulating tumor cells CTC clusters CTC detection CTC biology |
| url | https://doi.org/10.1007/s12672-024-00949-7 |
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