Antifungal and cytotoxic constituents from the endophytic fungus Penicillium sp.
New mellein derivative; 4-methylmellein (1) along with five known compounds: 4-hydroxymellein (2) and 6-hydroxymellein (3), tyrosol (4), cervesterol (5), and stigmast-4-ene-3-one (6) were isolated from the ethyl acetate extract of the endophytic fungus Penicillium sp. isolated from the leaf of Senec...
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| Format: | Article |
| Language: | English |
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Faculty of Pharmacy, Cairo University
2017-06-01
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| Series: | Bulletin of Faculty of Pharmacy Cairo University |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110093117300108 |
| _version_ | 1797970168959205376 |
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| author | Ehab S. Elkhayat Asmaa Mohamed Goda |
| author_facet | Ehab S. Elkhayat Asmaa Mohamed Goda |
| author_sort | Ehab S. Elkhayat |
| collection | DOAJ |
| description | New mellein derivative; 4-methylmellein (1) along with five known compounds: 4-hydroxymellein (2) and 6-hydroxymellein (3), tyrosol (4), cervesterol (5), and stigmast-4-ene-3-one (6) were isolated from the ethyl acetate extract of the endophytic fungus Penicillium sp. isolated from the leaf of Senecio flavus (Asteraceae). Structures were established by 1D and 2D NMR, in addition to UV, IR and MS spectrometry. Compounds (3, 4 and 6) were isolated for the first time from the genus Penicillium. Compounds 1–4 showed antifungal activity against F. oxysporum and variable activities against A. flavus and the yeast C. albicans. Compounds 1–3 showed cytotoxic activity against MCF-7 cell line. |
| first_indexed | 2024-04-11T03:13:41Z |
| format | Article |
| id | doaj.art-49ef165eaed64fb6a8e2c0be0adc8fc5 |
| institution | Directory Open Access Journal |
| issn | 1110-0931 |
| language | English |
| last_indexed | 2024-04-11T03:13:41Z |
| publishDate | 2017-06-01 |
| publisher | Faculty of Pharmacy, Cairo University |
| record_format | Article |
| series | Bulletin of Faculty of Pharmacy Cairo University |
| spelling | doaj.art-49ef165eaed64fb6a8e2c0be0adc8fc52023-01-02T10:54:28ZengFaculty of Pharmacy, Cairo UniversityBulletin of Faculty of Pharmacy Cairo University1110-09312017-06-01551858910.1016/j.bfopcu.2017.03.001Antifungal and cytotoxic constituents from the endophytic fungus Penicillium sp.Ehab S. Elkhayat0Asmaa Mohamed Goda1Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, EgyptDepartments of Medical Microbiology and Immunology, Faculty of Medicine, Sohag University, Sohag, EgyptNew mellein derivative; 4-methylmellein (1) along with five known compounds: 4-hydroxymellein (2) and 6-hydroxymellein (3), tyrosol (4), cervesterol (5), and stigmast-4-ene-3-one (6) were isolated from the ethyl acetate extract of the endophytic fungus Penicillium sp. isolated from the leaf of Senecio flavus (Asteraceae). Structures were established by 1D and 2D NMR, in addition to UV, IR and MS spectrometry. Compounds (3, 4 and 6) were isolated for the first time from the genus Penicillium. Compounds 1–4 showed antifungal activity against F. oxysporum and variable activities against A. flavus and the yeast C. albicans. Compounds 1–3 showed cytotoxic activity against MCF-7 cell line.http://www.sciencedirect.com/science/article/pii/S1110093117300108EndophytePencillium sp.Senecio flavus4-MethylmelleinCytotoxicityAntifungal activity |
| spellingShingle | Ehab S. Elkhayat Asmaa Mohamed Goda Antifungal and cytotoxic constituents from the endophytic fungus Penicillium sp. Bulletin of Faculty of Pharmacy Cairo University Endophyte Pencillium sp. Senecio flavus 4-Methylmellein Cytotoxicity Antifungal activity |
| title | Antifungal and cytotoxic constituents from the endophytic fungus Penicillium sp. |
| title_full | Antifungal and cytotoxic constituents from the endophytic fungus Penicillium sp. |
| title_fullStr | Antifungal and cytotoxic constituents from the endophytic fungus Penicillium sp. |
| title_full_unstemmed | Antifungal and cytotoxic constituents from the endophytic fungus Penicillium sp. |
| title_short | Antifungal and cytotoxic constituents from the endophytic fungus Penicillium sp. |
| title_sort | antifungal and cytotoxic constituents from the endophytic fungus penicillium sp |
| topic | Endophyte Pencillium sp. Senecio flavus 4-Methylmellein Cytotoxicity Antifungal activity |
| url | http://www.sciencedirect.com/science/article/pii/S1110093117300108 |
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