IMMUNOLOGICAL PARAMETERS IN BREAST CANCER PATIENTS UNDER BETALEUKIN ADJUVANT TREATMENT
Abstract. We have examined the effect of betaleukin on the immune parameters in breast cancer (BC) patients treated with cytostatic drug and surgery. Intravenous application of betaleukin for 5 days just before adjuvant chemotherapy have been shown to prevent both the decrease of blood immune cell c...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/427 |
| _version_ | 1797198083058040832 |
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| author | M. Staheeva E. Slonymskaya N. Babyshkina N. Cherdyntseva A. Simbirtsev A. Kladiev |
| author_facet | M. Staheeva E. Slonymskaya N. Babyshkina N. Cherdyntseva A. Simbirtsev A. Kladiev |
| author_sort | M. Staheeva |
| collection | DOAJ |
| description | Abstract. We have examined the effect of betaleukin on the immune parameters in breast cancer (BC) patients treated with cytostatic drug and surgery. Intravenous application of betaleukin for 5 days just before adjuvant chemotherapy have been shown to prevent both the decrease of blood immune cell count and the damage of their functional activity in BC patients with lymph node involvement N0–1. BC patients with wide spreading lymph node metastases N2 showed the protection of blood neutrophil activity but not lymphocyte subset count following betaleukin administration and chemotherapy. Positive effect of betaleukin was found to depend upon the adaptive state of patients. Betaleukin in turn appeared to display the adaptogenic activity. (Med. Immunol., 2005, vol.7, № 1, pp 63572) |
| first_indexed | 2024-03-08T05:50:34Z |
| format | Article |
| id | doaj.art-49ef38cfa4404dca9139db3856b25b40 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:54:13Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-49ef38cfa4404dca9139db3856b25b402024-04-22T13:07:36ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0171637210.15789/1563-0625-2005-1-63-72424IMMUNOLOGICAL PARAMETERS IN BREAST CANCER PATIENTS UNDER BETALEUKIN ADJUVANT TREATMENTM. Staheeva0E. Slonymskaya1N. Babyshkina2N. Cherdyntseva3A. Simbirtsev4A. Kladiev5ГУ НИИ онкологии ТНЦ СО РАМН, ТомскГУ НИИ онкологии ТНЦ СО РАМН, ТомскГУ НИИ онкологии ТНЦ СО РАМН, ТомскГУ НИИ онкологии ТНЦ СО РАМН, ТомскНИИ ОЧБ, Санкт–Петербург«Союзагромед», МоскваAbstract. We have examined the effect of betaleukin on the immune parameters in breast cancer (BC) patients treated with cytostatic drug and surgery. Intravenous application of betaleukin for 5 days just before adjuvant chemotherapy have been shown to prevent both the decrease of blood immune cell count and the damage of their functional activity in BC patients with lymph node involvement N0–1. BC patients with wide spreading lymph node metastases N2 showed the protection of blood neutrophil activity but not lymphocyte subset count following betaleukin administration and chemotherapy. Positive effect of betaleukin was found to depend upon the adaptive state of patients. Betaleukin in turn appeared to display the adaptogenic activity. (Med. Immunol., 2005, vol.7, № 1, pp 63572)https://www.mimmun.ru/mimmun/article/view/427betaleukinimmunitybreast cancer |
| spellingShingle | M. Staheeva E. Slonymskaya N. Babyshkina N. Cherdyntseva A. Simbirtsev A. Kladiev IMMUNOLOGICAL PARAMETERS IN BREAST CANCER PATIENTS UNDER BETALEUKIN ADJUVANT TREATMENT Медицинская иммунология betaleukin immunity breast cancer |
| title | IMMUNOLOGICAL PARAMETERS IN BREAST CANCER PATIENTS UNDER BETALEUKIN ADJUVANT TREATMENT |
| title_full | IMMUNOLOGICAL PARAMETERS IN BREAST CANCER PATIENTS UNDER BETALEUKIN ADJUVANT TREATMENT |
| title_fullStr | IMMUNOLOGICAL PARAMETERS IN BREAST CANCER PATIENTS UNDER BETALEUKIN ADJUVANT TREATMENT |
| title_full_unstemmed | IMMUNOLOGICAL PARAMETERS IN BREAST CANCER PATIENTS UNDER BETALEUKIN ADJUVANT TREATMENT |
| title_short | IMMUNOLOGICAL PARAMETERS IN BREAST CANCER PATIENTS UNDER BETALEUKIN ADJUVANT TREATMENT |
| title_sort | immunological parameters in breast cancer patients under betaleukin adjuvant treatment |
| topic | betaleukin immunity breast cancer |
| url | https://www.mimmun.ru/mimmun/article/view/427 |
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