Epigenetic Regulation by lncRNAs: An Overview Focused on UCA1 in Colorectal Cancer
Colorectal cancers have become the second leading cause of cancer-related deaths. In particular, acquired chemoresistance and metastatic lesions occurring in colorectal cancer are a major challenge for chemotherapy treatment. Accumulating evidence shows that long non-coding (lncRNAs) are involved in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/10/11/440 |
| _version_ | 1797708448032358400 |
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| author | Bernadette Neve Nicolas Jonckheere Audrey Vincent Isabelle Van Seuningen |
| author_facet | Bernadette Neve Nicolas Jonckheere Audrey Vincent Isabelle Van Seuningen |
| author_sort | Bernadette Neve |
| collection | DOAJ |
| description | Colorectal cancers have become the second leading cause of cancer-related deaths. In particular, acquired chemoresistance and metastatic lesions occurring in colorectal cancer are a major challenge for chemotherapy treatment. Accumulating evidence shows that long non-coding (lncRNAs) are involved in the initiation, progression, and metastasis of cancer. We here discuss the epigenetic mechanisms through which lncRNAs regulate gene expression in cancer cells. In the second part of this review, we focus on the role of lncRNA Urothelial Cancer Associated 1 (UCA1) to integrate research in different types of cancer in order to decipher its putative function and mechanism of regulation in colorectal cancer cells. UCA1 is highly expressed in cancer cells and mediates transcriptional regulation on an epigenetic level through the interaction with chromatin modifiers, by direct regulation via chromatin looping and/or by sponging the action of a diversity of miRNAs. Furthermore, we discuss the role of UCA1 in the regulation of cell cycle progression and its relation to chemoresistance in colorectal cancer cells. |
| first_indexed | 2024-03-12T06:21:38Z |
| format | Article |
| id | doaj.art-49f0bd5b8e6f4709ba6ded7a33d33d78 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T06:21:38Z |
| publishDate | 2018-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-49f0bd5b8e6f4709ba6ded7a33d33d782023-09-03T02:09:40ZengMDPI AGCancers2072-66942018-11-01101144010.3390/cancers10110440cancers10110440Epigenetic Regulation by lncRNAs: An Overview Focused on UCA1 in Colorectal CancerBernadette Neve0Nicolas Jonckheere1Audrey Vincent2Isabelle Van Seuningen3Inserm UMR-S 1172, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc), Team “Mucins, Epithelial Differentiation and Carcinogenesis”; University Lille; CHU Lille,59045, Lille CEDEX, FranceInserm UMR-S 1172, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc), Team “Mucins, Epithelial Differentiation and Carcinogenesis”; University Lille; CHU Lille,59045, Lille CEDEX, FranceInserm UMR-S 1172, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc), Team “Mucins, Epithelial Differentiation and Carcinogenesis”; University Lille; CHU Lille,59045, Lille CEDEX, FranceInserm UMR-S 1172, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer (JPArc), Team “Mucins, Epithelial Differentiation and Carcinogenesis”; University Lille; CHU Lille,59045, Lille CEDEX, FranceColorectal cancers have become the second leading cause of cancer-related deaths. In particular, acquired chemoresistance and metastatic lesions occurring in colorectal cancer are a major challenge for chemotherapy treatment. Accumulating evidence shows that long non-coding (lncRNAs) are involved in the initiation, progression, and metastasis of cancer. We here discuss the epigenetic mechanisms through which lncRNAs regulate gene expression in cancer cells. In the second part of this review, we focus on the role of lncRNA Urothelial Cancer Associated 1 (UCA1) to integrate research in different types of cancer in order to decipher its putative function and mechanism of regulation in colorectal cancer cells. UCA1 is highly expressed in cancer cells and mediates transcriptional regulation on an epigenetic level through the interaction with chromatin modifiers, by direct regulation via chromatin looping and/or by sponging the action of a diversity of miRNAs. Furthermore, we discuss the role of UCA1 in the regulation of cell cycle progression and its relation to chemoresistance in colorectal cancer cells.https://www.mdpi.com/2072-6694/10/11/440long non-coding RNA (lncRNA)lncRNA Urothelial Cancer Associated 1 (UCA1)colorectal cancer (CRC)competing endogenous RNAs (ceRNA) |
| spellingShingle | Bernadette Neve Nicolas Jonckheere Audrey Vincent Isabelle Van Seuningen Epigenetic Regulation by lncRNAs: An Overview Focused on UCA1 in Colorectal Cancer Cancers long non-coding RNA (lncRNA) lncRNA Urothelial Cancer Associated 1 (UCA1) colorectal cancer (CRC) competing endogenous RNAs (ceRNA) |
| title | Epigenetic Regulation by lncRNAs: An Overview Focused on UCA1 in Colorectal Cancer |
| title_full | Epigenetic Regulation by lncRNAs: An Overview Focused on UCA1 in Colorectal Cancer |
| title_fullStr | Epigenetic Regulation by lncRNAs: An Overview Focused on UCA1 in Colorectal Cancer |
| title_full_unstemmed | Epigenetic Regulation by lncRNAs: An Overview Focused on UCA1 in Colorectal Cancer |
| title_short | Epigenetic Regulation by lncRNAs: An Overview Focused on UCA1 in Colorectal Cancer |
| title_sort | epigenetic regulation by lncrnas an overview focused on uca1 in colorectal cancer |
| topic | long non-coding RNA (lncRNA) lncRNA Urothelial Cancer Associated 1 (UCA1) colorectal cancer (CRC) competing endogenous RNAs (ceRNA) |
| url | https://www.mdpi.com/2072-6694/10/11/440 |
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