β-Catenin is critical for cerebellar foliation and lamination.
The cerebellum has a conserved foliation pattern and a well-organized layered structure. The process of foliation and lamination begins around birth. β-catenin is a downstream molecule of Wnt signaling pathway, which plays a critical role in tissue organization. Lack of β-catenin at early embryonic...
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Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3656863?pdf=render |
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author | Jing Wen Hong-Bin Yang Bing Zhou Hui-Fang Lou Shumin Duan |
author_facet | Jing Wen Hong-Bin Yang Bing Zhou Hui-Fang Lou Shumin Duan |
author_sort | Jing Wen |
collection | DOAJ |
description | The cerebellum has a conserved foliation pattern and a well-organized layered structure. The process of foliation and lamination begins around birth. β-catenin is a downstream molecule of Wnt signaling pathway, which plays a critical role in tissue organization. Lack of β-catenin at early embryonic stages leads to either prenatal or neonatal death, therefore it has been difficult to resolve its role in cerebellar foliation and lamination. Here we used GFAP-Cre to ablate β-catenin in neuronal cells of the cerebellum after embryonic day 12.5, and found an unexpected role of β-catenin in determination of the foliation pattern. In the mutant mice, the positions of fissure formation were changed, and the meninges were improperly incorporated into fissures. At later stages, some lobules were formed by Purkinje cells remaining in deep regions of the cerebellum and the laminar structure was dramatically altered. Our results suggest that β-catenin is critical for cerebellar foliation and lamination. We also found a non cell-autonomous role of β-catenin in some developmental properties of major cerebellar cell types during specific stages. |
first_indexed | 2024-12-12T00:44:36Z |
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id | doaj.art-49f23768dfd349bb8e45c7fd5b722880 |
institution | Directory Open Access Journal |
issn | 1932-6203 |
language | English |
last_indexed | 2024-12-12T00:44:36Z |
publishDate | 2013-01-01 |
publisher | Public Library of Science (PLoS) |
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spelling | doaj.art-49f23768dfd349bb8e45c7fd5b7228802022-12-22T00:44:10ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0185e6445110.1371/journal.pone.0064451β-Catenin is critical for cerebellar foliation and lamination.Jing WenHong-Bin YangBing ZhouHui-Fang LouShumin DuanThe cerebellum has a conserved foliation pattern and a well-organized layered structure. The process of foliation and lamination begins around birth. β-catenin is a downstream molecule of Wnt signaling pathway, which plays a critical role in tissue organization. Lack of β-catenin at early embryonic stages leads to either prenatal or neonatal death, therefore it has been difficult to resolve its role in cerebellar foliation and lamination. Here we used GFAP-Cre to ablate β-catenin in neuronal cells of the cerebellum after embryonic day 12.5, and found an unexpected role of β-catenin in determination of the foliation pattern. In the mutant mice, the positions of fissure formation were changed, and the meninges were improperly incorporated into fissures. At later stages, some lobules were formed by Purkinje cells remaining in deep regions of the cerebellum and the laminar structure was dramatically altered. Our results suggest that β-catenin is critical for cerebellar foliation and lamination. We also found a non cell-autonomous role of β-catenin in some developmental properties of major cerebellar cell types during specific stages.http://europepmc.org/articles/PMC3656863?pdf=render |
spellingShingle | Jing Wen Hong-Bin Yang Bing Zhou Hui-Fang Lou Shumin Duan β-Catenin is critical for cerebellar foliation and lamination. PLoS ONE |
title | β-Catenin is critical for cerebellar foliation and lamination. |
title_full | β-Catenin is critical for cerebellar foliation and lamination. |
title_fullStr | β-Catenin is critical for cerebellar foliation and lamination. |
title_full_unstemmed | β-Catenin is critical for cerebellar foliation and lamination. |
title_short | β-Catenin is critical for cerebellar foliation and lamination. |
title_sort | β catenin is critical for cerebellar foliation and lamination |
url | http://europepmc.org/articles/PMC3656863?pdf=render |
work_keys_str_mv | AT jingwen bcateniniscriticalforcerebellarfoliationandlamination AT hongbinyang bcateniniscriticalforcerebellarfoliationandlamination AT bingzhou bcateniniscriticalforcerebellarfoliationandlamination AT huifanglou bcateniniscriticalforcerebellarfoliationandlamination AT shuminduan bcateniniscriticalforcerebellarfoliationandlamination |