Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells

Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells

Immunotherapy can induce antigen spreading of antitumor T cell response, which correlates with better outcomes. Here the authors show that tissue-resident memory CD8 T cells promote antigen spreading via lysing tumor cells and promoting their uptake and cross-presentation by dendritic cells, thereby...

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Bibliographic Details
Main Authors:	Evelyn Menares, Felipe Gálvez-Cancino, Pablo Cáceres-Morgado, Ehsan Ghorani, Ernesto López, Ximena Díaz, Juan Saavedra-Almarza, Diego A. Figueroa, Eduardo Roa, Sergio A. Quezada, Alvaro Lladser
Format:	Article
Language:	English
Published:	Nature Portfolio 2019-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-12319-x

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