Wnt-signaling pathway in pathogenesis of glioblastoma multiforme
The Wnt-signaling pathway regulates various biological processes, such as embryonic development, self-renewal, proliferation, differentiation and migration of stem cells. The Wnt-signaling is involved in tumor progression by aberrant activation in stem-like cells, called cancer stem cells, in differ...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2019-01-01
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| Series: | Успехи молекулярной онкологии |
| Subjects: | |
| Online Access: | https://umo.abvpress.ru/jour/article/view/178 |
| _version_ | 1826559145170436096 |
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| author | Yu. D. Vasilets N. E. Arnotskaya I. A. Kudryavtsev V. E. Shevchenko |
| author_facet | Yu. D. Vasilets N. E. Arnotskaya I. A. Kudryavtsev V. E. Shevchenko |
| author_sort | Yu. D. Vasilets |
| collection | DOAJ |
| description | The Wnt-signaling pathway regulates various biological processes, such as embryonic development, self-renewal, proliferation, differentiation and migration of stem cells. The Wnt-signaling is involved in tumor progression by aberrant activation in stem-like cells, called cancer stem cells, in different kinds of tumor, including multiform glioblastoma. The Wnt-signaling promotes stemness, invasion, metastasis, therapeutic and immune resistance of cancer stem cells in multiform glioblastoma. To summarize, targeting the Wnt-signaling pathway as an oncogenic driver is the future hope for effective therapy of glioblastoma for which current standard therapy is not effective.In this review, we focused on functions of the Wnt-signaling in cancer stem cells and involvement of the Wnt-signaling pathway in gliomagenesis. |
| first_indexed | 2024-03-12T04:17:52Z |
| format | Article |
| id | doaj.art-49f2e340a6d4423b95a5b9987533ca0d |
| institution | Directory Open Access Journal |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| last_indexed | 2025-03-14T08:55:44Z |
| publishDate | 2019-01-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj.art-49f2e340a6d4423b95a5b9987533ca0d2025-03-02T12:45:06ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872019-01-01549410310.17650/2313-805X-2018-5-4-94-103142Wnt-signaling pathway in pathogenesis of glioblastoma multiformeYu. D. Vasilets0N. E. Arnotskaya1I. A. Kudryavtsev2V. E. Shevchenko3Research Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaResearch Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaResearch Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaResearch Institute of Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaThe Wnt-signaling pathway regulates various biological processes, such as embryonic development, self-renewal, proliferation, differentiation and migration of stem cells. The Wnt-signaling is involved in tumor progression by aberrant activation in stem-like cells, called cancer stem cells, in different kinds of tumor, including multiform glioblastoma. The Wnt-signaling promotes stemness, invasion, metastasis, therapeutic and immune resistance of cancer stem cells in multiform glioblastoma. To summarize, targeting the Wnt-signaling pathway as an oncogenic driver is the future hope for effective therapy of glioblastoma for which current standard therapy is not effective.In this review, we focused on functions of the Wnt-signaling in cancer stem cells and involvement of the Wnt-signaling pathway in gliomagenesis.https://umo.abvpress.ru/jour/article/view/178wnt-signalingcancer stem cellsmultiform glioblastomaβ-catenin |
| spellingShingle | Yu. D. Vasilets N. E. Arnotskaya I. A. Kudryavtsev V. E. Shevchenko Wnt-signaling pathway in pathogenesis of glioblastoma multiforme Успехи молекулярной онкологии wnt-signaling cancer stem cells multiform glioblastoma β-catenin |
| title | Wnt-signaling pathway in pathogenesis of glioblastoma multiforme |
| title_full | Wnt-signaling pathway in pathogenesis of glioblastoma multiforme |
| title_fullStr | Wnt-signaling pathway in pathogenesis of glioblastoma multiforme |
| title_full_unstemmed | Wnt-signaling pathway in pathogenesis of glioblastoma multiforme |
| title_short | Wnt-signaling pathway in pathogenesis of glioblastoma multiforme |
| title_sort | wnt signaling pathway in pathogenesis of glioblastoma multiforme |
| topic | wnt-signaling cancer stem cells multiform glioblastoma β-catenin |
| url | https://umo.abvpress.ru/jour/article/view/178 |
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