Platelet-albumin-bilirubin score and neutrophil-to-lymphocyte ratio predict intensive care unit admission in patients with end-stage kidney disease infected with the Omicron variant of COVID-19: a single-center prospective cohort study
AbstractObjectives The objective of this study was to develop clinical scores to predict the risk of intensive care unit (ICU) admission in patients with COVID-19 and end stage kidney disease (ESKD).Methods This was a prospective study in which 100 patients with ESKD were enrolled and divided into t...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2199097 |
| _version_ | 1797658500367646720 |
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| author | Yufen Zhou Muyin Zhang Xiaojing Wu Xin Li Xu Hao Lili Xu Hao Li Panpan Qiao Ping Chen Weiming Wang |
| author_facet | Yufen Zhou Muyin Zhang Xiaojing Wu Xin Li Xu Hao Lili Xu Hao Li Panpan Qiao Ping Chen Weiming Wang |
| author_sort | Yufen Zhou |
| collection | DOAJ |
| description | AbstractObjectives The objective of this study was to develop clinical scores to predict the risk of intensive care unit (ICU) admission in patients with COVID-19 and end stage kidney disease (ESKD).Methods This was a prospective study in which 100 patients with ESKD were enrolled and divided into two groups: the ICU group and the non-ICU group. We utilized univariate logistic regression and nonparametric statistics to analyze the clinical characteristics and liver function changes of both groups. By plotting receiver operating characteristic curves, we identified clinical scores that could predict the risk of ICU admission.Results Out of the 100 patients with Omicron infection, 12 patients were transferred to the ICU due to disease aggravation, with an average of 9.08 days from hospitalization to ICU transfer. Patients transferred to the ICU more commonly experienced shortness of breath, orthopnea, and gastrointestinal bleeding. The peak liver function and changes from baseline in the ICU group were significantly higher, with p values <.05. We found that the baseline platelet-albumin-bilirubin score (PALBI) and neutrophil-to-lymphocyte ratio (NLR) were good predictors of ICU admission risk, with area under curve values of 0.713 and 0.770, respectively. These scores were comparable to the classic Acute Physiology and Chronic Health Evaluation II (APACHE-II) score (p > .05).Conclusion Patients with ESKD and Omicron infection who are transferred to the ICU are more likely to have abnormal liver function. The baseline PALBI and NLR scores can better predict the risk of clinical deterioration and early transfer to the ICU for treatment. |
| first_indexed | 2024-03-11T17:59:49Z |
| format | Article |
| id | doaj.art-49f38d72db7a4572a1262e236f5832e2 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-03-11T17:59:49Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-49f38d72db7a4572a1262e236f5832e22023-10-17T09:23:24ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145110.1080/0886022X.2023.2199097Platelet-albumin-bilirubin score and neutrophil-to-lymphocyte ratio predict intensive care unit admission in patients with end-stage kidney disease infected with the Omicron variant of COVID-19: a single-center prospective cohort studyYufen Zhou0Muyin Zhang1Xiaojing Wu2Xin Li3Xu Hao4Lili Xu5Hao Li6Panpan Qiao7Ping Chen8Weiming Wang9Department of Gastroenterology, Ruijin Hospital, Shanghai, ChinaDepartment of Nephrology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Nephrology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Nephrology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Nephrology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Nephrology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Nephrology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Nephrology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Gastroenterology, Ruijin Hospital, Shanghai, ChinaDepartment of Nephrology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, ChinaAbstractObjectives The objective of this study was to develop clinical scores to predict the risk of intensive care unit (ICU) admission in patients with COVID-19 and end stage kidney disease (ESKD).Methods This was a prospective study in which 100 patients with ESKD were enrolled and divided into two groups: the ICU group and the non-ICU group. We utilized univariate logistic regression and nonparametric statistics to analyze the clinical characteristics and liver function changes of both groups. By plotting receiver operating characteristic curves, we identified clinical scores that could predict the risk of ICU admission.Results Out of the 100 patients with Omicron infection, 12 patients were transferred to the ICU due to disease aggravation, with an average of 9.08 days from hospitalization to ICU transfer. Patients transferred to the ICU more commonly experienced shortness of breath, orthopnea, and gastrointestinal bleeding. The peak liver function and changes from baseline in the ICU group were significantly higher, with p values <.05. We found that the baseline platelet-albumin-bilirubin score (PALBI) and neutrophil-to-lymphocyte ratio (NLR) were good predictors of ICU admission risk, with area under curve values of 0.713 and 0.770, respectively. These scores were comparable to the classic Acute Physiology and Chronic Health Evaluation II (APACHE-II) score (p > .05).Conclusion Patients with ESKD and Omicron infection who are transferred to the ICU are more likely to have abnormal liver function. The baseline PALBI and NLR scores can better predict the risk of clinical deterioration and early transfer to the ICU for treatment.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2199097Omicron infectionend stage kidney diseaseabnormal liver functionICUplatelet-albumin-bilirubin scoreneutrophil-to-lymphocyte ratio |
| spellingShingle | Yufen Zhou Muyin Zhang Xiaojing Wu Xin Li Xu Hao Lili Xu Hao Li Panpan Qiao Ping Chen Weiming Wang Platelet-albumin-bilirubin score and neutrophil-to-lymphocyte ratio predict intensive care unit admission in patients with end-stage kidney disease infected with the Omicron variant of COVID-19: a single-center prospective cohort study Renal Failure Omicron infection end stage kidney disease abnormal liver function ICU platelet-albumin-bilirubin score neutrophil-to-lymphocyte ratio |
| title | Platelet-albumin-bilirubin score and neutrophil-to-lymphocyte ratio predict intensive care unit admission in patients with end-stage kidney disease infected with the Omicron variant of COVID-19: a single-center prospective cohort study |
| title_full | Platelet-albumin-bilirubin score and neutrophil-to-lymphocyte ratio predict intensive care unit admission in patients with end-stage kidney disease infected with the Omicron variant of COVID-19: a single-center prospective cohort study |
| title_fullStr | Platelet-albumin-bilirubin score and neutrophil-to-lymphocyte ratio predict intensive care unit admission in patients with end-stage kidney disease infected with the Omicron variant of COVID-19: a single-center prospective cohort study |
| title_full_unstemmed | Platelet-albumin-bilirubin score and neutrophil-to-lymphocyte ratio predict intensive care unit admission in patients with end-stage kidney disease infected with the Omicron variant of COVID-19: a single-center prospective cohort study |
| title_short | Platelet-albumin-bilirubin score and neutrophil-to-lymphocyte ratio predict intensive care unit admission in patients with end-stage kidney disease infected with the Omicron variant of COVID-19: a single-center prospective cohort study |
| title_sort | platelet albumin bilirubin score and neutrophil to lymphocyte ratio predict intensive care unit admission in patients with end stage kidney disease infected with the omicron variant of covid 19 a single center prospective cohort study |
| topic | Omicron infection end stage kidney disease abnormal liver function ICU platelet-albumin-bilirubin score neutrophil-to-lymphocyte ratio |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2199097 |
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