Preliminary Evaluations of [11C]Verubulin: Implications for Microtubule Imaging With PET

Preliminary Evaluations of [11C]Verubulin: Implications for Microtubule Imaging With PET

[11C]Verubulin (a.k.a.[11C]MCP-6827), [11C]HD-800 and [11C]colchicine have been developed for imaging microtubules (MTs) with positron emission tomography (PET). The objective of this work was to conduct an in vivo comparison of [11C]verubulin for MT imaging in mouse and rat brain, as well as an in...

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Bibliographic Details
Main Authors: Anton Lindberg, Andrew V. Mossine, Arturo Aliaga, Robert Hopewell, Gassan Massarweh, Pedro Rosa-Neto, Xia Shao, Vadim Bernard-Gauthier, Peter J. H. Scott, Neil Vasdev
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Neuroscience
Subjects:
microtubules
PET
carbon-11
[11C]verubulin
[11C]HD-800
[11C]colchicine
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.725873/full

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