Small High-Risk Uveal Melanomas Have a Lower Mortality Rate
Our aim was to determine whether size impacts on the difference in metastatic mortality of genetically high-risk (monosomy 3) uveal melanomas (UM). We undertook a retrospective analysis of data from a patient cohort with genetically characterized UM. All patients treated for UM in the Liverpool Ocul...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/9/2267 |
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| author | Rumana N. Hussain Sarah E. Coupland Helen Kalirai Azzam F. G. Taktak Antonio Eleuteri Bertil E. Damato Carl Groenewald Heinrich Heimann |
| author_facet | Rumana N. Hussain Sarah E. Coupland Helen Kalirai Azzam F. G. Taktak Antonio Eleuteri Bertil E. Damato Carl Groenewald Heinrich Heimann |
| author_sort | Rumana N. Hussain |
| collection | DOAJ |
| description | Our aim was to determine whether size impacts on the difference in metastatic mortality of genetically high-risk (monosomy 3) uveal melanomas (UM). We undertook a retrospective analysis of data from a patient cohort with genetically characterized UM. All patients treated for UM in the Liverpool Ocular Oncology Centre between 2007 and 2014, who had a prognostic genetic tumor analysis. Patients were subdivided into those with small (≤2.5 mm thickness) and large (>2.5 mm thickness) tumors. Survival analyses were performed using Gray rank statistics to calculate absolute probabilities of dying as a result of metastatic UM. The 5-year absolute risk of metastatic mortality of those with small monosomy 3 UM was significantly lower (23%) compared to the larger tumor group (50%) (<i>p</i> = 0.003). Small disomy 3 UM also had a lower absolute risk of metastatic mortality (0.8%) than large disomy 3 UM (6.4%) (<i>p</i> = 0.007). Hazard rates showed similar differences even with lead time bias correction estimates. We therefore conclude that earlier treatment of all small UM, particularly monosomy 3 UM, reduces the risk of metastatic disease and death. Our results would support molecular studies of even small UM, rather than ‘watch-and-wait strategies’. |
| first_indexed | 2024-03-10T11:36:26Z |
| format | Article |
| id | doaj.art-49f703989dbc473894ebeb689aa74f2e |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T11:36:26Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-49f703989dbc473894ebeb689aa74f2e2023-11-21T18:49:48ZengMDPI AGCancers2072-66942021-05-01139226710.3390/cancers13092267Small High-Risk Uveal Melanomas Have a Lower Mortality RateRumana N. Hussain0Sarah E. Coupland1Helen Kalirai2Azzam F. G. Taktak3Antonio Eleuteri4Bertil E. Damato5Carl Groenewald6Heinrich Heimann7Liverpool Ocular Oncology Centre, Liverpool University Hospitals NHS Foundation Trust, Liverpool L7 8XP, UKLiverpool Ocular Oncology Research Centre, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 7ZX, UKLiverpool Ocular Oncology Research Centre, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 7ZX, UKLiverpool Ocular Oncology Research Centre, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 7ZX, UKLiverpool Ocular Oncology Research Centre, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 7ZX, UKOcular Oncology Service, Moorfields Eye Hospital, London EC1V 2PD, UKLiverpool Ocular Oncology Centre, Liverpool University Hospitals NHS Foundation Trust, Liverpool L7 8XP, UKLiverpool Ocular Oncology Centre, Liverpool University Hospitals NHS Foundation Trust, Liverpool L7 8XP, UKOur aim was to determine whether size impacts on the difference in metastatic mortality of genetically high-risk (monosomy 3) uveal melanomas (UM). We undertook a retrospective analysis of data from a patient cohort with genetically characterized UM. All patients treated for UM in the Liverpool Ocular Oncology Centre between 2007 and 2014, who had a prognostic genetic tumor analysis. Patients were subdivided into those with small (≤2.5 mm thickness) and large (>2.5 mm thickness) tumors. Survival analyses were performed using Gray rank statistics to calculate absolute probabilities of dying as a result of metastatic UM. The 5-year absolute risk of metastatic mortality of those with small monosomy 3 UM was significantly lower (23%) compared to the larger tumor group (50%) (<i>p</i> = 0.003). Small disomy 3 UM also had a lower absolute risk of metastatic mortality (0.8%) than large disomy 3 UM (6.4%) (<i>p</i> = 0.007). Hazard rates showed similar differences even with lead time bias correction estimates. We therefore conclude that earlier treatment of all small UM, particularly monosomy 3 UM, reduces the risk of metastatic disease and death. Our results would support molecular studies of even small UM, rather than ‘watch-and-wait strategies’.https://www.mdpi.com/2072-6694/13/9/2267uveal melanomamonosomy 3metastatic risk |
| spellingShingle | Rumana N. Hussain Sarah E. Coupland Helen Kalirai Azzam F. G. Taktak Antonio Eleuteri Bertil E. Damato Carl Groenewald Heinrich Heimann Small High-Risk Uveal Melanomas Have a Lower Mortality Rate Cancers uveal melanoma monosomy 3 metastatic risk |
| title | Small High-Risk Uveal Melanomas Have a Lower Mortality Rate |
| title_full | Small High-Risk Uveal Melanomas Have a Lower Mortality Rate |
| title_fullStr | Small High-Risk Uveal Melanomas Have a Lower Mortality Rate |
| title_full_unstemmed | Small High-Risk Uveal Melanomas Have a Lower Mortality Rate |
| title_short | Small High-Risk Uveal Melanomas Have a Lower Mortality Rate |
| title_sort | small high risk uveal melanomas have a lower mortality rate |
| topic | uveal melanoma monosomy 3 metastatic risk |
| url | https://www.mdpi.com/2072-6694/13/9/2267 |
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