Synthesis and Broad Antiviral Activity of Novel 2-aryl-isoindolin-1-ones towards Diverse Enterovirus A71 Clinical Isolates

Synthesis and Broad Antiviral Activity of Novel 2-aryl-isoindolin-1-ones towards Diverse Enterovirus A71 Clinical Isolates

Enterovirus 71 (EV-A71) is the main causative pathogen of childhood hand, foot and mouth disease. Effective medicine is currently unavailable for the treatment of this viral disease. Using the fragment-hopping strategy, a series of 2-aryl-isoindolin-1-one compounds were designed, synthesized and inv...

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Bibliographic Details
Main Authors: Yixuan Wang, Huiqiang Wang, Xinbei Jiang, Zhi Jiang, Tingting Guo, Xingyue Ji, Yanping Li, Yuhuan Li, Zhuorong Li
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
2-aryl-isoindolin-1-ones
enterovirus A71
synthesis
antiviral
structure activity relationship
Online Access:http://www.mdpi.com/1420-3049/24/5/985

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