Nanostructured Electrospun Polycaprolactone—Propolis Mats Composed of Different Morphologies for Potential Use in Wound Healing
This study aimed to investigate different types of morphologies obtained using the electrospinning process to produce a material that enables wound healing while performing a controlled release. Using benign solvents, the authors prepared and characterised electrospun polycaprolactone mats loaded wi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/16/5351 |
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| author | Agnes Chacor de Figueiredo Javier Mauricio Anaya-Mancipe Aline Oliveira da Silva de Barros Ralph Santos-Oliveira Marcos Lopes Dias Rossana Mara da Silva Moreira Thiré |
| author_facet | Agnes Chacor de Figueiredo Javier Mauricio Anaya-Mancipe Aline Oliveira da Silva de Barros Ralph Santos-Oliveira Marcos Lopes Dias Rossana Mara da Silva Moreira Thiré |
| author_sort | Agnes Chacor de Figueiredo |
| collection | DOAJ |
| description | This study aimed to investigate different types of morphologies obtained using the electrospinning process to produce a material that enables wound healing while performing a controlled release. Using benign solvents, the authors prepared and characterised electrospun polycaprolactone mats loaded with propolis, a popular extract in traditional medicine with potential for skin repair. Different morphologies were obtained from distinct storage periods of the solution before electrospinning to investigate the effect of PCL hydrolysis (average diameters of fibres and beads: 159.2–280.5 nm and 1.9–5.6 μm, respectively). Phytochemical and FTIR analyses of the extract confirmed propolis composition. GPC and viscosity analyses showed a decrease in polymer molecular weight over the storage period (about a 70% reduction over 14 days) and confirmed that it was responsible for the nanostructure diversity. Moreover, propolis acted as a lubricant agent, affecting the spun solutions’ viscosity and the thermal properties and hydrophilicity of the mats. All samples were within the value range of the water vapour transpiration rate of the commercial products (1263.08 to 2179.84 g/m<sup>2</sup>·day). Even though the presence of beads did not affect the propolis release pattern, an in vitro wound-healing assay showed that propolis-loaded mats composed of beaded fibres increased the cell migration process. Thus, these films could present the potential for use in wound dressing applications. |
| first_indexed | 2024-03-09T04:01:22Z |
| format | Article |
| id | doaj.art-49f91244445f4b42952304186ad21ba0 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T04:01:22Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-49f91244445f4b42952304186ad21ba02023-12-03T14:12:26ZengMDPI AGMolecules1420-30492022-08-012716535110.3390/molecules27165351Nanostructured Electrospun Polycaprolactone—Propolis Mats Composed of Different Morphologies for Potential Use in Wound HealingAgnes Chacor de Figueiredo0Javier Mauricio Anaya-Mancipe1Aline Oliveira da Silva de Barros2Ralph Santos-Oliveira3Marcos Lopes Dias4Rossana Mara da Silva Moreira Thiré5COPPE/Program of Metallurgical and Materials Engineering—PEMM, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-599, RJ, BrazilCOPPE/Program of Metallurgical and Materials Engineering—PEMM, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-599, RJ, BrazilBrazilian Nuclear Energy Commission, Nuclear Engineering Institute—IEN, Rio de Janeiro 21941-906, RJ, BrazilBrazilian Nuclear Energy Commission, Nuclear Engineering Institute—IEN, Rio de Janeiro 21941-906, RJ, BrazilInstitute of Macromolecules Professora Eloisa Mano—IMA, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-598, RJ, BrazilCOPPE/Program of Metallurgical and Materials Engineering—PEMM, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-599, RJ, BrazilThis study aimed to investigate different types of morphologies obtained using the electrospinning process to produce a material that enables wound healing while performing a controlled release. Using benign solvents, the authors prepared and characterised electrospun polycaprolactone mats loaded with propolis, a popular extract in traditional medicine with potential for skin repair. Different morphologies were obtained from distinct storage periods of the solution before electrospinning to investigate the effect of PCL hydrolysis (average diameters of fibres and beads: 159.2–280.5 nm and 1.9–5.6 μm, respectively). Phytochemical and FTIR analyses of the extract confirmed propolis composition. GPC and viscosity analyses showed a decrease in polymer molecular weight over the storage period (about a 70% reduction over 14 days) and confirmed that it was responsible for the nanostructure diversity. Moreover, propolis acted as a lubricant agent, affecting the spun solutions’ viscosity and the thermal properties and hydrophilicity of the mats. All samples were within the value range of the water vapour transpiration rate of the commercial products (1263.08 to 2179.84 g/m<sup>2</sup>·day). Even though the presence of beads did not affect the propolis release pattern, an in vitro wound-healing assay showed that propolis-loaded mats composed of beaded fibres increased the cell migration process. Thus, these films could present the potential for use in wound dressing applications.https://www.mdpi.com/1420-3049/27/16/5351electrospinningmorphology structurespropolispolycaprolactonedrug delivery |
| spellingShingle | Agnes Chacor de Figueiredo Javier Mauricio Anaya-Mancipe Aline Oliveira da Silva de Barros Ralph Santos-Oliveira Marcos Lopes Dias Rossana Mara da Silva Moreira Thiré Nanostructured Electrospun Polycaprolactone—Propolis Mats Composed of Different Morphologies for Potential Use in Wound Healing Molecules electrospinning morphology structures propolis polycaprolactone drug delivery |
| title | Nanostructured Electrospun Polycaprolactone—Propolis Mats Composed of Different Morphologies for Potential Use in Wound Healing |
| title_full | Nanostructured Electrospun Polycaprolactone—Propolis Mats Composed of Different Morphologies for Potential Use in Wound Healing |
| title_fullStr | Nanostructured Electrospun Polycaprolactone—Propolis Mats Composed of Different Morphologies for Potential Use in Wound Healing |
| title_full_unstemmed | Nanostructured Electrospun Polycaprolactone—Propolis Mats Composed of Different Morphologies for Potential Use in Wound Healing |
| title_short | Nanostructured Electrospun Polycaprolactone—Propolis Mats Composed of Different Morphologies for Potential Use in Wound Healing |
| title_sort | nanostructured electrospun polycaprolactone propolis mats composed of different morphologies for potential use in wound healing |
| topic | electrospinning morphology structures propolis polycaprolactone drug delivery |
| url | https://www.mdpi.com/1420-3049/27/16/5351 |
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