Genome-Wide Association Study of Body Weight Trait in Yaks
The yak is the largest meat-producing mammal around the Tibetan Plateau, and it plays an important role in the economic development and maintenance of the ecological environment throughout much of the Asian highlands. Understanding the genetic components of body weight is key for future improvement...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/12/14/1855 |
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| author | Jiabo Wang Xiaowei Li Wei Peng Jincheng Zhong Mingfeng Jiang |
| author_facet | Jiabo Wang Xiaowei Li Wei Peng Jincheng Zhong Mingfeng Jiang |
| author_sort | Jiabo Wang |
| collection | DOAJ |
| description | The yak is the largest meat-producing mammal around the Tibetan Plateau, and it plays an important role in the economic development and maintenance of the ecological environment throughout much of the Asian highlands. Understanding the genetic components of body weight is key for future improvement in yak breeding; therefore, genome-wide association studies (GWAS) were performed, and the results were used to mine plant and animal genetic resources. We conducted whole genome sequencing on 406 Maiwa yaks at 10 × coverage. Using a multiple loci mixed linear model (MLMM), fixed and random model circulating probability unification (FarmCPU), and Bayesian-information and linkage-disequilibrium iteratively nested keyway (BLINK), we found that a total of 25,000 single-nucleotide polymorphisms (SNPs) were distributed across chromosomes, and seven markers were identified as significantly (<i>p</i>-values < 3.91 × 10<sup>−7</sup>) associated with the body weight trait,. Several candidate genes, including <i>MFSD4</i>, <i>LRRC37B</i>, and <i>NCAM2</i>, were identified. This research will help us achieve a better understanding of the genotype–phenotype relationship for body weight. |
| first_indexed | 2024-03-09T03:47:17Z |
| format | Article |
| id | doaj.art-49f99386d5cc4a5f9b6ab2983df46bed |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T03:47:17Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-49f99386d5cc4a5f9b6ab2983df46bed2023-12-03T14:32:14ZengMDPI AGAnimals2076-26152022-07-011214185510.3390/ani12141855Genome-Wide Association Study of Body Weight Trait in YaksJiabo Wang0Xiaowei Li1Wei Peng2Jincheng Zhong3Mingfeng Jiang4Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education and Sichuan Province, Southwest Minzu University, Chengdu 610041, ChinaSichuan Longri Breeding Farm, Hongyuan 610041, ChinaQinghai Academy of Animal Science and Veterinary Science, Qinghai University, Xining 810000, ChinaKey Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education and Sichuan Province, Southwest Minzu University, Chengdu 610041, ChinaKey Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education and Sichuan Province, Southwest Minzu University, Chengdu 610041, ChinaThe yak is the largest meat-producing mammal around the Tibetan Plateau, and it plays an important role in the economic development and maintenance of the ecological environment throughout much of the Asian highlands. Understanding the genetic components of body weight is key for future improvement in yak breeding; therefore, genome-wide association studies (GWAS) were performed, and the results were used to mine plant and animal genetic resources. We conducted whole genome sequencing on 406 Maiwa yaks at 10 × coverage. Using a multiple loci mixed linear model (MLMM), fixed and random model circulating probability unification (FarmCPU), and Bayesian-information and linkage-disequilibrium iteratively nested keyway (BLINK), we found that a total of 25,000 single-nucleotide polymorphisms (SNPs) were distributed across chromosomes, and seven markers were identified as significantly (<i>p</i>-values < 3.91 × 10<sup>−7</sup>) associated with the body weight trait,. Several candidate genes, including <i>MFSD4</i>, <i>LRRC37B</i>, and <i>NCAM2</i>, were identified. This research will help us achieve a better understanding of the genotype–phenotype relationship for body weight.https://www.mdpi.com/2076-2615/12/14/1855yakgenome-wide association studybody weightheritabilityTibetan Plateau |
| spellingShingle | Jiabo Wang Xiaowei Li Wei Peng Jincheng Zhong Mingfeng Jiang Genome-Wide Association Study of Body Weight Trait in Yaks Animals yak genome-wide association study body weight heritability Tibetan Plateau |
| title | Genome-Wide Association Study of Body Weight Trait in Yaks |
| title_full | Genome-Wide Association Study of Body Weight Trait in Yaks |
| title_fullStr | Genome-Wide Association Study of Body Weight Trait in Yaks |
| title_full_unstemmed | Genome-Wide Association Study of Body Weight Trait in Yaks |
| title_short | Genome-Wide Association Study of Body Weight Trait in Yaks |
| title_sort | genome wide association study of body weight trait in yaks |
| topic | yak genome-wide association study body weight heritability Tibetan Plateau |
| url | https://www.mdpi.com/2076-2615/12/14/1855 |
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