Migratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair?
Harmonic mechanisms orchestrate neurogenesis in the healthy brain within specific neurogenic niches, which generate neurons from neural stem cells as a homeostatic mechanism. These newly generated neurons integrate into existing neuronal circuits to participate in different brain tasks. Despite the...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/7/6587 |
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| author | Noelia Geribaldi-Doldán Livia Carrascal Patricia Pérez-García José M. Oliva-Montero Ricardo Pardillo-Díaz Samuel Domínguez-García Carlos Bernal-Utrera Ricardo Gómez-Oliva Sergio Martínez-Ortega Cristina Verástegui Pedro Nunez-Abades Carmen Castro |
| author_facet | Noelia Geribaldi-Doldán Livia Carrascal Patricia Pérez-García José M. Oliva-Montero Ricardo Pardillo-Díaz Samuel Domínguez-García Carlos Bernal-Utrera Ricardo Gómez-Oliva Sergio Martínez-Ortega Cristina Verástegui Pedro Nunez-Abades Carmen Castro |
| author_sort | Noelia Geribaldi-Doldán |
| collection | DOAJ |
| description | Harmonic mechanisms orchestrate neurogenesis in the healthy brain within specific neurogenic niches, which generate neurons from neural stem cells as a homeostatic mechanism. These newly generated neurons integrate into existing neuronal circuits to participate in different brain tasks. Despite the mechanisms that protect the mammalian brain, this organ is susceptible to many different types of damage that result in the loss of neuronal tissue and therefore in alterations in the functionality of the affected regions. Nevertheless, the mammalian brain has developed mechanisms to respond to these injuries, potentiating its capacity to generate new neurons from neural stem cells and altering the homeostatic processes that occur in neurogenic niches. These alterations may lead to the generation of new neurons within the damaged brain regions. Notwithstanding, the activation of these repair mechanisms, regeneration of neuronal tissue within brain injuries does not naturally occur. In this review, we discuss how the different neurogenic niches respond to different types of brain injuries, focusing on the capacity of the progenitors generated in these niches to migrate to the injured regions and activate repair mechanisms. We conclude that the search for pharmacological drugs that stimulate the migration of newly generated neurons to brain injuries may result in the development of therapies to repair the damaged brain tissue. |
| first_indexed | 2024-03-11T05:34:45Z |
| format | Article |
| id | doaj.art-49fcbd1ab7944c95a33fd9222a53a729 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T05:34:45Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-49fcbd1ab7944c95a33fd9222a53a7292023-11-17T16:53:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01247658710.3390/ijms24076587Migratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair?Noelia Geribaldi-Doldán0Livia Carrascal1Patricia Pérez-García2José M. Oliva-Montero3Ricardo Pardillo-Díaz4Samuel Domínguez-García5Carlos Bernal-Utrera6Ricardo Gómez-Oliva7Sergio Martínez-Ortega8Cristina Verástegui9Pedro Nunez-Abades10Carmen Castro11Departamento de Anatomía y Embriología Humanas, Facultad de Medicina, Universidad de Cádiz, 11003 Cádiz, SpainInstituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), 11009 Cádiz, SpainInstituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), 11009 Cádiz, SpainInstituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), 11009 Cádiz, SpainInstituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), 11009 Cádiz, SpainInstituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), 11009 Cádiz, SpainInstituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), 11009 Cádiz, SpainInstituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), 11009 Cádiz, SpainInstituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), 11009 Cádiz, SpainDepartamento de Anatomía y Embriología Humanas, Facultad de Medicina, Universidad de Cádiz, 11003 Cádiz, SpainInstituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), 11009 Cádiz, SpainInstituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), 11009 Cádiz, SpainHarmonic mechanisms orchestrate neurogenesis in the healthy brain within specific neurogenic niches, which generate neurons from neural stem cells as a homeostatic mechanism. These newly generated neurons integrate into existing neuronal circuits to participate in different brain tasks. Despite the mechanisms that protect the mammalian brain, this organ is susceptible to many different types of damage that result in the loss of neuronal tissue and therefore in alterations in the functionality of the affected regions. Nevertheless, the mammalian brain has developed mechanisms to respond to these injuries, potentiating its capacity to generate new neurons from neural stem cells and altering the homeostatic processes that occur in neurogenic niches. These alterations may lead to the generation of new neurons within the damaged brain regions. Notwithstanding, the activation of these repair mechanisms, regeneration of neuronal tissue within brain injuries does not naturally occur. In this review, we discuss how the different neurogenic niches respond to different types of brain injuries, focusing on the capacity of the progenitors generated in these niches to migrate to the injured regions and activate repair mechanisms. We conclude that the search for pharmacological drugs that stimulate the migration of newly generated neurons to brain injuries may result in the development of therapies to repair the damaged brain tissue.https://www.mdpi.com/1422-0067/24/7/6587neurogenesisneuroblast migrationAlzheimer’s diseaseParkinson’s diseaseHuntington’s diseasebrain injury and stroke |
| spellingShingle | Noelia Geribaldi-Doldán Livia Carrascal Patricia Pérez-García José M. Oliva-Montero Ricardo Pardillo-Díaz Samuel Domínguez-García Carlos Bernal-Utrera Ricardo Gómez-Oliva Sergio Martínez-Ortega Cristina Verástegui Pedro Nunez-Abades Carmen Castro Migratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair? International Journal of Molecular Sciences neurogenesis neuroblast migration Alzheimer’s disease Parkinson’s disease Huntington’s disease brain injury and stroke |
| title | Migratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair? |
| title_full | Migratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair? |
| title_fullStr | Migratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair? |
| title_full_unstemmed | Migratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair? |
| title_short | Migratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair? |
| title_sort | migratory response of cells in neurogenic niches to neuronal death the onset of harmonic repair |
| topic | neurogenesis neuroblast migration Alzheimer’s disease Parkinson’s disease Huntington’s disease brain injury and stroke |
| url | https://www.mdpi.com/1422-0067/24/7/6587 |
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