Serum transthyretin and aminotransferases are associated with lean mass in people with coronary heart disease: Further insights from the CARE-CR study
BackgroundLow muscle mass disproportionately affects people with coronary heart disease compared to healthy controls but is under-researched and insufficiently treated. Inflammation, poor nutrition, and neural decline might contribute to low muscle mass. This study aimed to assess circulatory biomar...
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1094733/full |
| _version_ | 1797902950683639808 |
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| author | Emily James Emily James Emily James Stuart Goodall Simon Nichols Simon Nichols Karen Walker Sean Carroll Alasdair F. O’Doherty Lee Ingle |
| author_facet | Emily James Emily James Emily James Stuart Goodall Simon Nichols Simon Nichols Karen Walker Sean Carroll Alasdair F. O’Doherty Lee Ingle |
| author_sort | Emily James |
| collection | DOAJ |
| description | BackgroundLow muscle mass disproportionately affects people with coronary heart disease compared to healthy controls but is under-researched and insufficiently treated. Inflammation, poor nutrition, and neural decline might contribute to low muscle mass. This study aimed to assess circulatory biomarkers related to these mechanisms [albumin, transthyretin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and C-terminal agrin fragment] and their relationship with muscle mass in people with coronary heart disease. Our findings could be beneficial to indicate mechanisms of sarcopenia, detect sarcopenia, and evaluate treatment.MethodsSerum blood samples from people with coronary heart disease were analysed for biomarker concentrations using enzyme-linked immunosorbent assays. Skeletal muscle mass was estimated using dual X-ray absorptiometry derived appendicular lean mass and reported as skeletal muscle index (SMI; kg m−2), and as a proportion of total body mass [appendicular skeletal mass (ASM%)]. Low muscle mass was defined as a SMI <7.0 and <6.0 kg m−2, or ASM% <25.72 and <19.43% for men and women, respectively. Associations between biomarkers and lean mass were adjusted for age and inflammation.ResultsSixty-four people were assessed; 14 (21.9%) had low muscle mass. People with low muscle mass had lower transthyretin (effect size 0.34, p = 0.007), ALT (effect size 0.34, p = 0.008), and AST (effect size 0.26, p = 0.037) concentrations, compared to those with normal muscle mass. SMI was associated with inflammation-corrected ALT (r = 0.261, p = 0.039) and with inflammation- and age-adjusted AST/ALT ratio (r = −0.257, p = 0.044). Albumin and C-terminal agrin fragment were not associated with muscle mass indices.ConclusionCirculatory transthyretin, ALT and AST were associated with low muscle mass in people with coronary heart disease. Low concentrations of these biomarkers might indicate that low muscle mass is partially explained by poor nutrition and high inflammation in this cohort. Targeted treatments to address these factors could be considered for people with coronary heart disease. |
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| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-10T09:25:18Z |
| publishDate | 2023-02-01 |
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| spelling | doaj.art-49fcc7fc0cb74e0580a09b2b2503959d2023-02-20T05:32:28ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-02-011010.3389/fmed.2023.10947331094733Serum transthyretin and aminotransferases are associated with lean mass in people with coronary heart disease: Further insights from the CARE-CR studyEmily James0Emily James1Emily James2Stuart Goodall3Simon Nichols4Simon Nichols5Karen Walker6Sean Carroll7Alasdair F. O’Doherty8Lee Ingle9Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne, United KingdomDiabetes Research Centre, University of Leicester, Leicester, United KingdomNIHR Leicester Biomedical Research Centre, Leicester, United KingdomDepartment of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne, United KingdomSport and Physical Activity Research Group, Sheffield Hallam University, Sheffield, United KingdomAdvanced Wellbeing Research Centre, Sheffield Hallam University, Sheffield, United KingdomDepartment of Applied Sciences, Northumbria University, Newcastle upon Tyne, United KingdomSchool of Sport, Exercise and Rehabilitation Sciences, University of Hull, Hull, United KingdomDepartment of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne, United KingdomSchool of Sport, Exercise and Rehabilitation Sciences, University of Hull, Hull, United KingdomBackgroundLow muscle mass disproportionately affects people with coronary heart disease compared to healthy controls but is under-researched and insufficiently treated. Inflammation, poor nutrition, and neural decline might contribute to low muscle mass. This study aimed to assess circulatory biomarkers related to these mechanisms [albumin, transthyretin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and C-terminal agrin fragment] and their relationship with muscle mass in people with coronary heart disease. Our findings could be beneficial to indicate mechanisms of sarcopenia, detect sarcopenia, and evaluate treatment.MethodsSerum blood samples from people with coronary heart disease were analysed for biomarker concentrations using enzyme-linked immunosorbent assays. Skeletal muscle mass was estimated using dual X-ray absorptiometry derived appendicular lean mass and reported as skeletal muscle index (SMI; kg m−2), and as a proportion of total body mass [appendicular skeletal mass (ASM%)]. Low muscle mass was defined as a SMI <7.0 and <6.0 kg m−2, or ASM% <25.72 and <19.43% for men and women, respectively. Associations between biomarkers and lean mass were adjusted for age and inflammation.ResultsSixty-four people were assessed; 14 (21.9%) had low muscle mass. People with low muscle mass had lower transthyretin (effect size 0.34, p = 0.007), ALT (effect size 0.34, p = 0.008), and AST (effect size 0.26, p = 0.037) concentrations, compared to those with normal muscle mass. SMI was associated with inflammation-corrected ALT (r = 0.261, p = 0.039) and with inflammation- and age-adjusted AST/ALT ratio (r = −0.257, p = 0.044). Albumin and C-terminal agrin fragment were not associated with muscle mass indices.ConclusionCirculatory transthyretin, ALT and AST were associated with low muscle mass in people with coronary heart disease. Low concentrations of these biomarkers might indicate that low muscle mass is partially explained by poor nutrition and high inflammation in this cohort. Targeted treatments to address these factors could be considered for people with coronary heart disease.https://www.frontiersin.org/articles/10.3389/fmed.2023.1094733/fullagrinalbuminaminotransferasesbiomarkerscoronary heart diseasemuscle |
| spellingShingle | Emily James Emily James Emily James Stuart Goodall Simon Nichols Simon Nichols Karen Walker Sean Carroll Alasdair F. O’Doherty Lee Ingle Serum transthyretin and aminotransferases are associated with lean mass in people with coronary heart disease: Further insights from the CARE-CR study Frontiers in Medicine agrin albumin aminotransferases biomarkers coronary heart disease muscle |
| title | Serum transthyretin and aminotransferases are associated with lean mass in people with coronary heart disease: Further insights from the CARE-CR study |
| title_full | Serum transthyretin and aminotransferases are associated with lean mass in people with coronary heart disease: Further insights from the CARE-CR study |
| title_fullStr | Serum transthyretin and aminotransferases are associated with lean mass in people with coronary heart disease: Further insights from the CARE-CR study |
| title_full_unstemmed | Serum transthyretin and aminotransferases are associated with lean mass in people with coronary heart disease: Further insights from the CARE-CR study |
| title_short | Serum transthyretin and aminotransferases are associated with lean mass in people with coronary heart disease: Further insights from the CARE-CR study |
| title_sort | serum transthyretin and aminotransferases are associated with lean mass in people with coronary heart disease further insights from the care cr study |
| topic | agrin albumin aminotransferases biomarkers coronary heart disease muscle |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1094733/full |
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